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Curated Journal Articles on Mesothelioma

Can CT and MR Shape and Textural Features Differentiate Benign Versus Malignant Pleural Lesions?

92 ± 0. 05 (P .
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Prophylactic radiotherapy for procedure tract metastases in mesothelioma: a review

SUMMARY: Recent studies have shown that prophylactic radiotherapy should not be routinely used to prevent PTMs in mesothelioma. Instead patients should undergo careful clinical follow-up to ensure PTMs are identified and treated promptly to minimize symptoms.
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Three-dimensional finite-element based deformable image registration for evaluation of pleural cavity irradiation during photodynamic therapy

CONCLUSION: The method used is appropriate for analyzing problems over complicated domains, such as when the domain changes (as in a solid-state reaction with a moving boundary), when the desired precision varies over the entire domain, or when the solution lacks smoothness. Implementing this method in real-time for clinical applications and in situ monitoring of the under- or over- exposed regions to light during PDT can significantly improve the treatment for mesothelioma.
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Pleurectomy-decortication in malignant pleural mesothelioma: are different surgical techniques associated with different outcomes? Results from a multicentre study

CONCLUSIONS: Whether the P/D is extended or not, it shows similarly good outcomes in terms of early results and survival rate. In contrast, a partial pleurectomy, which leaves gross tumour behind, has no impact on survival.
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Folic acid phenotype (FAP) is a superior biomarker predicting response to pemetrexed-based chemotherapy in malignant pleural mesothelioma

CONCLUSION: Our results indicate that the balance between folic acid uptake, activation and metabolism plays a crucial role in response to pemetrexed-based chemotherapy and the prognosis of MPM patients. Implementing this marker profile in MPM stratification may help to individualize MPM-therapy more efficiently.
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Epidemiology of Environmental Exposure and Malignant Mesothelioma.

While recent studies continue to improve our understanding of the types of EE to asbestos still present, challenges remain. We highlighted a few new research directions, such as a need for reliable matrixes to identify common and less recognized environmental exposure types, asbestos biomarker studies specifically focusing on environmental exposures, and research focused on populations and geographic areas that have not been previously studied.
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What is Mesothelioma?

Learn more about this fatal cancer, including the causes, symptoms, and treatments for both pleural and peritoneal tumors of the mesothelium at our parent site MesotheliomaCenter.

CD44 and its ligand hyaluronan as potential biomarkers in malignant pleural mesothelioma: evidence and perspectives.

This review will summarize the biology and diagnostic implication of CD44 and HA as well as the interaction of both molecules in MPM that will demonstrate their potential as biomarkers. Augmentation of the current markers in MPM may lead to an earlier diagnosis and management of this disease.
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Malignant pleural mesothelioma: single-institution experience of 101 patients over a 15-year period.

A significant difference in survival was observed in patients undergoing surgery versus no surgery (p = . 008), between the different histological types (p .
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Analysis of fibulin-3 after exposure to asbestos-like fibers.

The present study also suggested that the Fibulin-3 overexpression may reflect a defensive response of the tissues after exogenous stimuli and may be implicated in cancer development, especially in the context of fluoro-edenite contamination. However, further studies are necessary in order to make Fibulin-3 a customized screening tool.
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A novel BRCA1-associated protein-1 isoform affects response of mesothelioma cells to drugs impairing BRCA1-mediated DNA repair.

CONCLUSION: These observations suggest that BAP1Δ does regulate DNA damage response and influences drug sensitivity. It might therefore be relevant to investigate whether patients with high expression of BAP1Δ may be responsive to PARP/PI3K-mTOR.
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