Causation
Bisecting-GlcNAc on Asn388 is characteristic to ERC/mesothelin expressed on epithelioid mesothelioma cells
Journal of Biochemistry 2021 April 1 [Link] Haruhiko Fujihira, Daisuke Takakura, Atsushi Matsuda, Masaaki Abe, Michiyo Miyazaki, Tomomi Nakagawa, Kazunori Kajino, Kaori Denda-Nagai, Miki Noji, Okio Hino, Tatsuro Irimura Abstract Mesothelioma is a highly aggressive tumor associated with asbestos exposure and is histologically classified into three types: epithelioid-type, sarcomatoid-type, and biphasic-type. The prognosis of mesothelioma…
Read MoreClonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment
Nature Communications 2021 March 19 [Link] Min Zhang, Jin-Li Luo, Qianqian Sun, James Harber, Alan G Dawson, Apostolos Nakas, Sara Busacca, Annabel J Sharkey, David Waller, Michael T Sheaff, Cathy Richards, Peter Wells-Jordan, Aarti Gaba, Charlotte Poile, Essa Y Baitei, Aleksandra Bzura, Joanna Dzialo, Maymun Jama, John Le Quesne, Amrita Bajaj, Luke Martison, Jacqui A…
Read MoreUse of preclinical models for malignant pleural mesothelioma
Thorax 2021 March 10 [Link] Marie Shamseddin, Joanna Obacz, Mathew J Garnett, Robert Campbell Rintoul, Hayley Elizabeth Francies, Stefan John Marciniak Abstract Malignant pleural mesothelioma (MPM) is an aggressive cancer most commonly caused by prior exposure to asbestos. Median survival is 12-18 months, since surgery is ineffective and chemotherapy offers minimal benefit. Preclinical models that…
Read MoreMalignant mesothelioma without asbestos exposure diagnosed during EGFR-TKI treatment of lung adenocarcinoma: A case report
Cancer Treatment and Research Communications 2021 February 24 [Link] Xiaomin Niu, Chenglei Zhou, Aiyan Hu, Lingzi Su, Dan Lin, Hui Han, Yan Lu Abstract Synchronous malignant mesothelioma (MM) and lung carcinoma are extremely rare in patients without a history of asbestos exposure and poses tremendous difficulties in clinical management. We report a patient without asbestos…
Read MoreClinical prognostic factors in pleural mesothelioma: best supportive care and anti-tumor treatments in a real-life setting
Acta Oncologica 2021 January 27 [Link] Thomas Ringgaard Petersen, Vasiliki Panou, Christos Meristoudis, Ulla Møller Weinreich, Oluf Dimitri Røe Abstract Background: This study aims to investigate patient- and disease characteristics associated with survival in malignant pleural mesothelioma (MPM) patients with anti-tumor treatment or with best supportive care (BSC). Materials and methods: Consecutive MPM cases diagnosed…
Read MoreThe Search for an Interesting Partner to Combine with PD-L1 Blockade in Mesothelioma: Focus on TIM-3 and LAG-3
Cancers 2021 January 14 [Link] Elly Marcq, Jonas R M Van Audenaerde, Jorrit De Waele, Céline Merlin, Patrick Pauwels, Jan P van Meerbeeck, Scott A Fisher, Evelien L J Smits Abstract Malignant pleural mesothelioma (MPM) is an aggressive cancer that is causally associated with previous asbestos exposure in most afflicted patients. The prognosis of patients…
Read MoreLiving with mesothelioma: A qualitative study of the experiences of male military veterans in the UK
European Journal of Oncology Nursing 2020 December 19 [Link] Stephanie Ejegi-Memeh, Liz Darlison, Anne Moylan, Angela Tod, Virginia Sherborne, Clare Warnock, Bethany Hope Taylor Abstract Purpose: The UK has the highest incidence of mesothelioma in the world. Evidence in the United States suggests that mesothelioma may disproportionately affect military veterans. However, there has been no…
Read MoreMalignant pleural neoplasm with both differentiation of epithelioid mesothelioma and squamous-cell carcinoma, a rare phenomena
Diagnostic Cytopathology 2020 December 21 [Link] Ashley Re, David Shersher, Ashleigh Allen, Roland Schwarting, Shuyue Ren Abstract Malignant mesothelioma, a neoplasm arising within the serosal surfaces, has been linked closely to asbestos exposure. We present a case of 72-year-old male with a 27 year work-related history of asbestos exposure who presented with dyspnea. Chest computed…
Read MoreFollow-up of Soluble Mesothelin-Related Protein Levels in Participants With Asbestos-Related Disorders
Safety and Health at Work 2020 December [Link] Eun-Kee Park, Anthony R Johnson, Donald Wilson, Paul S Thomas, Deborah H Yates Abstract Background: Asbestos exposure is associated with the development of the cancer malignant mesothelioma (MM). Measurement of soluble mesothelin-related protein (SMRP) has been suggested as a method for detection of MM in its early…
Read MoreExploration of identifying novel serum biomarkers for malignant mesothelioma using iTRAQ combined with 2D-LC-MS/MS
Environmental Research 2020 November 13 [Link] Hailing Xia, Lingfang Feng, Lijun Lin, Zhaoqiang Jiang, Junqiang Chen, Wei Shi, Shibo Ying, Min Yu, Li Ju, Lijin Zhu, Li Shi, Xing Zhang, Jianlin Lou Abstract Malignant mesothelioma (MM) is an aggressive cancer linked to asbestos exposure. Its poor prognosis makes early diagnosis extremely important, which would provide…
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