Causation
The usefulness of biomarkers in diagnosis of asbestos-induced malignant pleural mesothelioma
Human and Experimental Toxicology 2021 May 17 [Link] Zübeyde Tanrıverdi, Fatih Meteroglu, Hande Yüce, Abdurrahman Şenyiğit, Mümtaz Işcan, Songül Unüvar Abstract Introduction: Malignant pleural mesothelioma (MPM) is a malignant tumor that is associated mostly with asbestos exposure. The present study was to evaluates the diagnostic value of neopterin, periostin, YKL-40, Tenascin-C (TNC), and Indolamine 2,3-dioxygenase…
Read MoreEmerging avenues in immunotherapy for the management of malignant pleural mesothelioma
BMC Pulmonary Medicine 2021 May 5 [Link] Steven G Gray Abstract Background: The role of immunotherapy in cancer is now well-established, and therapeutic options such as checkpoint inhibitors are increasingly being approved in many cancers such as non-small cell lung cancer (NSCLC). Malignant pleural mesothelioma (MPM) is a rare orphan disease associated with prior exposure…
Read MoreGender and the experiences of living with mesothelioma: A thematic analysis
European Journal of Oncology Nursing 2021 April 28 [Link] Stephanie Ejegi-Memeh, Steve Robertson, Bethany Taylor, Liz Darlison, Angela Tod Abstract Purpose: Mesothelioma is a terminal cancer caused by exposure to asbestos. As a cancer with a higher rate in men than women, women’s experiences of living with mesothelioma are often underexplored. Furthermore, men’s experiences are…
Read More[The Current Therapy of Asbestos-Associated Malignant Pleural Mesothelioma – An Expert Consensus Paper]
Pneumologie 2021 May 4 [Link] C Aigner, T Brüning, W E E Eberhardt, M Härter, H-P Kaelberlah, M Metzenmacher, R Shah, C Taube, M Thomas Abstract Asbestos-related mesotheliomas belong to the group of the most frequent occupational diseases in Germany, reaching about 1,000 new cases per year. The disease has a dismal prognosis because most…
Read MoreA nontoxic dose of chrysotile can malignantly transform Met-5A cells, in which microRNA-28 has inhibitory effects
Journal of Applied Toxicology 2021 April 22 [Link] Fangfang Zhang, Xiuyuan Yuan, Hongjing Sun, Xianhong Yin, Yanan Gao, Min Zhang, Zhenyu Jia, Min Yu, Shibo Ying, Hailing Xia, Li Ju, Yun Xiao, He Tao, Jianlin Lou, Lijin Zhu Abstract Chrysotile, which is classified as a class I carcinogen by the International Agency for Research on…
Read MoreEffect of IL-15 addition on asbestos-induced suppression of human cytotoxic T lymphocyte induction
Environmental Health and Preventive Medicine 2021 [Link] Naoko Kumagai-Takei, Yasumitsu Nishimura, Hidenori Matsuzaki, Suni Lee, Kei Yoshitome, Tatsuo Ito, Takemi Otsuki Abstract Background: Asbestos fibers possess tumorigenicity and are thought to cause mesothelioma. We have previously reported that exposure to asbestos fibers causes a reduction in antitumor immunity. Asbestos exposure in the mixed lymphocyte reaction…
Read MoreIncidence of mesothelioma and asbestosis by occupation in a diverse workforce
American Journal of Industrial Medicine 2021 April 8 [Link] Nathan L DeBono, Hunter Warden, Chloë Logar-Henderson, Sharara Shakik, Mamadou Dakouo, Jill MacLeod, Paul A Demers Abstract Objective: We sought to characterize detailed patterns of mesothelioma and asbestosis incidence in the workforce as part of an occupational disease surveillance program in Ontario, Canada. Methods: The Occupational…
Read MoreBisecting-GlcNAc on Asn388 is characteristic to ERC/mesothelin expressed on epithelioid mesothelioma cells
Journal of Biochemistry 2021 April 1 [Link] Haruhiko Fujihira, Daisuke Takakura, Atsushi Matsuda, Masaaki Abe, Michiyo Miyazaki, Tomomi Nakagawa, Kazunori Kajino, Kaori Denda-Nagai, Miki Noji, Okio Hino, Tatsuro Irimura Abstract Mesothelioma is a highly aggressive tumor associated with asbestos exposure and is histologically classified into three types: epithelioid-type, sarcomatoid-type, and biphasic-type. The prognosis of mesothelioma…
Read MoreClonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment
Nature Communications 2021 March 19 [Link] Min Zhang, Jin-Li Luo, Qianqian Sun, James Harber, Alan G Dawson, Apostolos Nakas, Sara Busacca, Annabel J Sharkey, David Waller, Michael T Sheaff, Cathy Richards, Peter Wells-Jordan, Aarti Gaba, Charlotte Poile, Essa Y Baitei, Aleksandra Bzura, Joanna Dzialo, Maymun Jama, John Le Quesne, Amrita Bajaj, Luke Martison, Jacqui A…
Read MoreUse of preclinical models for malignant pleural mesothelioma
Thorax 2021 March 10 [Link] Marie Shamseddin, Joanna Obacz, Mathew J Garnett, Robert Campbell Rintoul, Hayley Elizabeth Francies, Stefan John Marciniak Abstract Malignant pleural mesothelioma (MPM) is an aggressive cancer most commonly caused by prior exposure to asbestos. Median survival is 12-18 months, since surgery is ineffective and chemotherapy offers minimal benefit. Preclinical models that…
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