Peritoneal (Abdominal Mesothelioma)
The Rarest of the Rare: A Case of BAP1-Mutated Primary Peritoneal Mesothelioma
Cureus 2021 September 29 [Link] Aanchal Gupta, Alisa Vasileva, Sukesh Manthri Abstract Malignant mesotheliomas (MM), as described are rare tumors that are mostly associated with occupational exposure to asbestos. They most commonly occur in the pleura. Other unfamiliar sites where they can occur are the peritoneum, pericardium, and tunica vaginalis. There is no significant correlation…
Read MoreNon-resectable Malignant Peritoneal Mesothelioma Treated with Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) Plus Systemic Chemotherapy Could Lead to Secondary Complete Cytoreductive Surgery: A Cohort Study
Annals of Surgical Oncology 2021 October 28 [Link] Vahan Kepenekian, Julien Péron, Benoit You, Isabelle Bonnefoy, Laurent Villeneuve, Mohammad Alyami, Naoual Bakrin, Pascal Rousset, Nazim Benzerdjeb, Olivier Glehen Abstract Background: Diffuse malignant peritoneal mesothelioma (DMPM) is an aggressive primary peritoneal neoplasia. At diagnosis, few patients are eligible for a recommended cytoreductive surgery (CRS) and hyperthermic…
Read MorePhase 2 Study of Olaparib in Malignant Mesothelioma and Correlation of Efficacy With Germline or Somatic Mutations in BAP1 Gene
JTO Clinical and Research Reports 2021 September 17 [Link] Azam Ghafoor, Idrees Mian, Cathy Wagner, Yvonne Mallory, Maria Garcia Agra, Betsy Morrow, Jun S Wei, Javed Khan, Anish Thomas, Manjistha Sengupta, Seth M Steinberg, Raffit Hassan Abstract Introduction: PARP inhibition may enhance antitumor responses in BAP1-associated mesothelioma by inducing synthetic lethality. Methods: A single-center, nonrandomized,…
Read MoreA rare case of benign multicystic peritoneal mesothelioma misdiagnosed as hydatid cyst found in the liver parenchyma and abdomen cavity of a male with asbestos exposure
BMC Gastroenterology 2021 October 12 [Link] Kelarji Ahmad Beshr, Alshutaihi Mohammad Sami, Ghazal Ahmad, Mahli Nihad, Sarab Agha Abstract Background: Benign Multicystic Peritoneal Mesothelioma (BMPM) is one of the rarest diseases in medicine with only more than 200 cases worldwide. This paper aims to report a case of Benign Multicystic Peritoneal Mesothelioma that strangely arose…
Read MoreMatrix Metalloproteinases as Biomarkers and Treatment Targets in Mesothelioma: A Systematic Review
Biomolecules 2021 August 25 [Link] Danijela Štrbac, Vita Dolžan Abstract Metalloproteinases (MMPs) have an important role in tissue remodeling and have been shown to have an effect on tumor progression, invasion, metastasis formation, and apoptosis in several tumors, including mesothelioma. Mesothelioma is a rare tumor arising from pleura and peritoneum and is frequently associated with…
Read MoreInvestigating the Efficacy of Zingerone on Mesothelioma and the Role of TRPV1 in This Effect
Nutrition and Cancer 2021 September 17 [Link] Sabahattin Cömertpay, Abdülmecit Gül, Mehmet Delibaş, Mehmet Semih Tekin Turhan Abstract Mesothelioma is a highly lethal cancer developing in the lung, heart, and abdominal membranes. Zingerone, a capsaicin-like bioactive compound, has been shown to have anticancer properties. Transient Receptor Potential Vanilloid 1 (TRPV1) is an ion channel involving…
Read MoreInvestigating the Efficacy of Zingerone on Mesothelioma and the Role of TRPV1 in This Effect
Nutrition and Cancer 2021 September 17 [Link] Sabahattin Cömertpay, Abdülmecit Gül, Mehmet Delibaş, Mehmet Semih Tekin Turhan Abstract Mesothelioma is a highly lethal cancer developing in the lung, heart, and abdominal membranes. Zingerone, a capsaicin-like bioactive compound, has been shown to have anticancer properties. Transient Receptor Potential Vanilloid 1 (TRPV1) is an ion channel involving…
Read MoreMalignant peritoneal mesothelioma: correlation between CT imaging features and histologic subtypes
Abdominal Radiology 2021 August 3 [Link] Isha D Atre, Gaurav V Watane, Mukesh G Harisinghani Abstract Purpose: To identify correlation between CT imaging features and histologic subtypes of Malignant Peritoneal Mesothelioma (MPM). Methods: This was a retrospective single-center study of 51 consecutive patients with the diagnosis of Malignant Peritoneal Mesothelioma (MPM). The tumors were classified…
Read MoreSOX6 Expression Is Sensitive for Peritoneal Epithelioid Malignant Mesothelioma, But Not Specific in the Differential Diagnosis With Tubo-ovarian Serous Neoplasia
The American Journal of Surgical Pathology 2021 August 19 [Link] David B Chapel, Michelle S Hirsch Abstract Primary peritoneal malignant mesothelioma (MM) can demonstrate morphologic overlap with low-grade and high-grade tubo-ovarian serous neoplasms; it is also biologically and prognostically distinct from benign mesothelial proliferations. Currently, there is no single biomarker that can definitively distinguish these…
Read MoreCombination of Plasma-Based Metabolomics and Machine Learning Algorithm Provides a Novel Diagnostic Strategy for Malignant Mesothelioma
Diagnostics 2021 July 16 [Link] Abstract Background: Malignant mesothelioma (MM) is an aggressive and incurable carcinoma that is primarily caused by asbestos exposure. However, the current diagnostic tool for MM is still under-developed. Therefore, the aim of this study is to explore the diagnostic significance of a strategy that combined plasma-based metabolomics with machine learning…
Read More