Luminol Chemiluminescence Reports Photodynamic Therapy-Generated Neutrophil Activity In Vivo and Serves as a Biomarker of Therapeutic Efficacy.

Photochemistry and Photobiology 2018 October 25 [Link] Davis RW 4th, Snyder E, Miller J, Carter S, Houser C, Klampatsa A, Albelda S, Cengel K, Busch TM Abstract Inflammatory cells, most especially neutrophils, can be a necessary component of the anti-tumor activity occurring after administration of photodynamic therapy. Generation of neutrophil responses has been suggested to…

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Malignant pleural mesothelioma segmentation for photodynamic therapy planning

Computerized Medical Imaging Society 2017 July [Epub ahead of print] [Link Brahim W, Mestiri M, Betrouni N, Hamrouni K Abstract Medical imaging modalities such as computed tomography (CT) combined with computer-aided diagnostic processing have already become important part of clinical routine specially for pleural diseases. The segmentation of the thoracic cavity represents an extremely important…

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Malignant pleural mesothelioma segmentation for photodynamic therapy planning

Computerized Medical Imaging Society 2017 July [Epub ahead of print] [Link] Brahim W, Mestiri M, Betrouni N, Hamrouni K Abstract Medical imaging modalities such as computed tomography (CT) combined with computer-aided diagnostic processing have already become important part of clinical routine specially for pleural diseases. The segmentation of the thoracic cavity represents an extremely important…

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Intraoperative adjuncts for malignant pleural mesothelioma

Translational Lung Cancer Research 2017 June [Link] Chan WH, Sugarbaker DJ, Burt BM Abstract Malignant pleural mesothelioma (MPM) is a rapidly fatal disease. Multimodality surgically based therapies may extend survival in select patients, however, local relapse after resection is common. Novel intraoperative adjunctive therapies including heated intraoperative chemotherapy (HIOC), heated intraoperative povidone-iodine (PVP-I), and photodynamic…

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Three-dimensional finite-element based deformable image registration for evaluation of pleural cavity irradiation during photodynamic therapy

Medical Physics 2017 April [Epub ahead of print] [Link] Penjweini R, Kim MM, Zhu TC Abstract PURPOSE: Photodynamic therapy (PDT) is used after surgical resection to treat the microscopic disease for malignant pleural mesothelioma and to increase survival rates. As accurate light delivery is imperative to PDT efficacy, the deformation of the pleural volume during…

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Extended Pleurectomy-Decortication-Based Treatment for Advanced Stage Epithelial Mesothelioma Yielding a Median Survival of Nearly Three Years

The Annals of Thoracic Surgery 2017 March [Epub November 5] [Link] Friedberg JS, Simone CB 2nd, Culligan MJ, Barsky AR, Doucette A, McNulty S, Hahn SM, Alley E, Sterman DH, Glatstein E, Cengel KA Abstract BACKGROUND: The purpose of this study was to assess survival for patients with malignant pleural mesothelioma (MPM), epithelial subtype, utilizing…

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Real-time light dosimetry for intra-cavity photodynamic therapy: Application for pleural mesothelioma treatment

Photodiagnosis and photodynamic therapy 2017 February 22 [Epub ahead of print] [Link] Betrouni N, Munck C, Bensoltana W, Baert G, Dewalle-Vignion AS, Scherpereel A, Mordon S Abstract Complete and homogeneous illumination of the target is necessary for the success of a photodynamic therapy (PDT) procedure. In most applications, light dosimetry is done using detectors placed…

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A Comparison of Singlet Oxygen Explicit Dosimetry (SOED) and Singlet Oxygen Luminescence Dosimetry (SOLD) for Photofrin-Mediated Photodynamic Therapy

Cancers (Basel) 2016 December 6 [Link] Kim MM, Penjweini R, Gemmell NR, Veilleux I, McCarthy A, Buller GS, Hadfield RH, Wilson BC, Zhu TC Abstract Accurate photodynamic therapy (PDT) dosimetry is critical for the use of PDT in the treatment of malignant and nonmalignant localized diseases. A singlet oxygen explicit dosimetry (SOED) model has been…

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