Biomarkers
Matrix Metalloproteinases as Biomarkers and Treatment Targets in Mesothelioma: A Systematic Review
Biomolecules 2021 August 25 [Link] Danijela Štrbac, Vita Dolžan Abstract Metalloproteinases (MMPs) have an important role in tissue remodeling and have been shown to have an effect on tumor progression, invasion, metastasis formation, and apoptosis in several tumors, including mesothelioma. Mesothelioma is a rare tumor arising from pleura and peritoneum and is frequently associated with…
Read MoreIntegrated genomics point to immune vulnerabilities in pleural mesothelioma
Scientific Reports 2021 September 27 [Link] Anca Nastase, Amit Mandal, Shir Kiong Lu, Hima Anbunathan, Deborah Morris-Rosendahl, Yu Zhi Zhang, Xiao-Ming Sun, Spyridon Gennatas, Robert C Rintoul, Matthew Edwards, Alex Bowman, Tatyana Chernova, Tim Benepal, Eric Lim, Anthony Newman Taylor, Andrew G Nicholson, Sanjay Popat, Anne E Willis, Marion MacFarlane, Mark Lathrop, Anne M Bowcock,…
Read MoreFour Immune-Related Genes (FN1, UGCG, CHPF2 and THBS2) as Potential Diagnostic and Prognostic Biomarkers for Carbon Nanotube-Induced Mesothelioma
International Journal of General Medicine 2021 August 29 [Link] Dongli Xie, Jianchen Hu, Tong Wu, Kangli Cao, Xiaogang Luo Abstract Background: Malignant pleural mesothelioma (MPM), a highly aggressive cancer, was mainly attributed to asbestos exposure. Carbon nanotubes (CNTs) share similar negative features to asbestos, provoking concerns about their contribution to MPM. This study was used…
Read MoreEvidence-based diagnostic performance of novel biomarkers for the diagnosis of malignant mesothelioma in effusion cytology
Cancer Cytopathology 2021 September 3 [Link] Ilaria Girolami, Ersilia Lucenteforte, Albino Eccher, Stefano Marletta, Matteo Brunelli, Paolo Graziano, Pasquale Pisapia, Umberto Malapelle, Giancarlo Troncone, Aldo Scarpa, Tao Huang, Liron Pantanowitz Abstract Cytology effusions are often the only material available for diagnosing malignant pleural mesothelioma (MPM). However, the cytomorphological features alone are not always diagnostic, and…
Read MoreSOX6 Expression Is Sensitive for Peritoneal Epithelioid Malignant Mesothelioma, But Not Specific in the Differential Diagnosis With Tubo-ovarian Serous Neoplasia
The American Journal of Surgical Pathology 2021 August 19 [Link] David B Chapel, Michelle S Hirsch Abstract Primary peritoneal malignant mesothelioma (MM) can demonstrate morphologic overlap with low-grade and high-grade tubo-ovarian serous neoplasms; it is also biologically and prognostically distinct from benign mesothelial proliferations. Currently, there is no single biomarker that can definitively distinguish these…
Read MoreThe Updating of Biological Functions of Methyltransferase SETDB1 and Its Relevance in Lung Cancer and Mesothelioma
International Journal of Molecular Sciences 2021 July 10 [Link] Li Yuan, Boshu Sun, Liangliang Xu, Limin Chen, Wenbin Ou Abstract SET domain bifurcated 1 (SETDB1) is a histone H3 lysine 9 (H3K9) methyltransferase that exerts important effects on epigenetic gene regulation. SETDB1 complexes (SETDB1-KRAB-KAP1, SETDB1-DNMT3A, SETDB1-PML, SETDB1-ATF7IP-MBD1) play crucial roles in the processes of histone…
Read MoreRecent Patent based perspective on diagnostic and therapeutic interventions in Malignant Mesothelioma: Is Drug Repositioning knocking the door?
Recent Patient Anticancer Drug Discovery 2021 July 11 [Link] Vikas Yadav, Roghaiyeh Safari Abstract Background: Malignant Mesothelioma (MM), an orphan but aggressive malignancy of the mesothelial membrane, is a fatal tumor. Global epidemic related to malignant pleural mesothelioma is on the rise, so there is a need to explore novel biomarkers and ingenious therapeutic approaches…
Read MoreMembranous HEG1 expression is a useful marker in the differential diagnosis of epithelioid and biphasic malignant mesothelioma versus carcinomas
Pathology International 2021 July 9 [Link] Kenzo Hiroshima, Di Wu, Eitetsu Koh, Yasuo Sekine, Daisuke Ozaki, Toshikazu Yusa, Tadao Nakazawa, Shoutaro Tsuji, Yohei Miyagi, Ann E Walts, Alberto M Marchevsky, Aliya N Husain, Kohzoh Imai Abstract Sialylated HEG1 has been reported as a highly specific and sensitive mesothelioma marker but a comprehensive evaluation of its…
Read MoreAn EBC/Plasma miRNA Signature Discriminates Lung Adenocarcinomas From Pleural Mesothelioma and Healthy Controls
Frontiers in Oncology 2021 June 15 [Link] Alice Faversani, Chiara Favero, Laura Dioni, Angela Cecilia Pesatori, Valentina Bollati, Matteo Montoli, Valeria Musso, Andrea Terrasi, Nicola Fusco, Mario Nosotti, Valentina Vaira, Alessandro Palleschi Abstract Background: Despite significant improvement in screening programs for cancers of the respiratory district, especially in at-risk subjects, early disease detection is still…
Read MoreDetection of circulating immunosuppressive cytokines in malignant pleural mesothelioma patients for prognostic stratification
Cytokine 2021 June 19 [Link] Loredana Urso, Micol Silic-Benussi, Alice Boscolo, Martina Lorenzi, Laura Bonanno, Francesca Lunardi, Valentina Guarneri, Fiorella Calabrese, Federico Rea, PierFranco Conte, Giulia Pasello Abstract Background: No data on circulating biomarkers for the prognostic stratification of Malignant Pleural Mesothelioma (MPM) patients are available. We prospectively explored the prognostic role of circulating monocyte…
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