Biomarkers
Verification of a Blood-Based Targeted Proteomics Signature for Malignant Pleural Mesothelioma
Cancer Epidemiology, Biomarkers, and Prevention 2020 July 30 [Link] Ferdinando Cerciello, Meena Choi, Sara L Sinicropi-Yao, Katie Lomeo, Joseph M Amann, Emanuela Felley-Bosco, Rolf A Stahel, Bruce W S Robinson, Jenette Creaney, Harvey I Pass, Olga Vitek, David P Carbone Abstract Background: We have verified a mass spectrometry (MS)-based targeted proteomics signature for the detection…
Read MoreNew vistas in malignant mesothelioma: MicroRNA architecture and NRF2/MAPK signal transduction
Life Sciences 2020 July 22 [Link] Manav Gandhi, Sujit Nair Abstract Malignant mesothelioma (MM) is a cancer of the mesothelial lining of the pleura, peritoneum, pericardium and testes. The most common form is asbestos-linked MM that is etiologically linked to repeated asbestos exposure with a long latency period, although non-asbestos MM has also been reported.…
Read MoreMesothelioma Biomarkers: A Review Highlighting Contributions from the Early Detection Research Network
Cancer Epidemiology, Biomarkers, and Prevention 2020 July 22 [Link] Harvey I Pass, Marjan Alimi, Michele Carbone, Haining Yang, Chandra M Goparaju Abstract Background: Malignant Pleural Mesothelioma (MPM) is an asbestos related neoplasm which can only be treated successfully when correctly diagnosed and treated in early stages. The asbestos exposed population serves as a high risk…
Read MoreVerification of a blood based targeted proteomics signature for malignant pleural mesothelioma
Cancer Epidemiol Biomarkers, July 30, 2020 (Epub ahead of print) [Link] Ferdinando Cerciello, et.al. Abstract Background: We have verified a mass spectrometry (MS) based targeted proteomics signature for the detection of malignant pleural mesothelioma (MPM) from the blood. Methods: A seven-peptide biomarker MPM signature by targeted proteomics in serum was identified in a previous independent…
Read MoreTreatment response monitoring in patients with advanced malignancies using cell-free SHOX2 and SEPT9 DNA methylation in blood: An observational prospective study.
The Journal of Molecular Diagnostics 2020 April 30 [Link] de Vos L, Jung M, Koerber RM, Bawden EG, Holderried TAW, Dietrich J, Bootz F, Brossart P, Kristiansen G, Dietrich D Abstract Patients with incurable cancer usually receive palliative treatment with significant toxicity and limited efficacy. Methylation analysis of circulating cell-free DNA in blood from cancer…
Read MorePutative Biomarkers for Malignant Pleural Mesothelioma Suggested by Proteomic Analysis of Cell Secretome.
Cancer Genomics & Proteomics 2020 May-June [Link] Lacerenza S, Ciregia F, Giusti L, Bonotti A, Greco V, Giannaccini G, D’Antongiovanni V, Fallahi P, Pieroni L, Cristaudo A, Lucacchini A, Mazzoni MR, Foddis R Abstract BACKGROUND:Malignant pleural mesothelioma (MPM) a rare neoplasm linked to asbestos exposure is characterized by a poor prognosis. Soluble mesothelin is currently…
Read MoreChromatographic Detection of 8-Hydroxy-2′-Deoxyguanosine in Leukocytes of Asbestos Exposed Workers for Assessing Past and Recent Carcinogen Exposures.
Diagnostics 2020 April 21 [Link] Cellai F, Bonassi S, Cristaudo A, Bonotti A, Neri M, Ceppi M, Bruzzone M, Milić M, Munnia A, Peluso M Abstract Asbestos fibers include a group of silicate minerals that occur in the environment and are widely employed in occupational settings. Asbestos exposure has been associated to various chronic diseases;…
Read MoreModulation of microRNA expression levels after naturally occurring asbestiform fibers exposure as a diagnostic biomarker of mesothelial neoplastic transformation.
Ecotoxicology and Environmental Safety 2020 April 21 [Link] Filetti V, Falzone L, Rapisarda V, Caltabiano R, Eleonora Graziano AC, Ledda C, Loreto C Abstract Fluoro-edenite (FE) is a silicate mineral identified in the lava products of Monte Calvario from stone quarries located in the southeast of Biancavilla, a small city of the Etnean volcanic complex…
Read MoreExtracellular vesicles as biomarkers in malignant pleural mesothelioma: A review.
Critical Review in Oncology and Hematology 2020 April 9 [Link] Ahmadzada T, Kao S, Reid G, Clarke S, Grau GE, Hosseini-Beheshti E Abstract Extracellular vesicles (EV) are secreted by all cells, including cancer cells, as a mode of intercellular transport and communication. The main types of EV known to date include exosomes, microvesicles and apoptotic…
Read MoreCirculating Epigenetic Biomarkers in Malignant Pleural Mesothelioma: State of the Art and critical Evaluation.
Frontiers in Oncology 2020 April 3 [Link] Ferrari L, Carugno M, Mensi C, Pesatori AC Abstract Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer, which originates from the mesothelial cells of the pleura and is associated with asbestos exposure. In light of its aggressive nature, late diagnosis and dismal prognosis, there is an…
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