Environmental Research 2020 November 13 [Link] Hailing Xia, Lingfang Feng, Lijun Lin, Zhaoqiang Jiang, Junqiang Chen, Wei Shi, Shibo Ying, Min Yu, Li Ju, Lijin Zhu, Li Shi, Xing Zhang, Jianlin Lou Abstract Malignant mesothelioma (MM) is an aggressive cancer linked to asbestos exposure. Its poor prognosis makes early diagnosis extremely important, which would provide…

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Journal of Pathology and Translational Medicine 2020 November 9 [Link] Hanife Gulnihal Ozdemir, Sermin Coban Kokten, Nagehan Ozdemir Barisik Abstract Background: Malignant mesothelioma is a highly aggressive tumor that can be confused with a benign mesothelial lesion, especially cytomorphologic lesions. BRCA1-associated protein 1 (BAP1) acts as a tumor suppressor. In this study, we aim to…

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Respirology Case Reports 2020 October 26 [Link] Mia MacMillan, Bapti Roy, Sally McLaren, Anna K Nowak, Rajesh Thomas, Y C Gary Lee Abstract We report a rare case of early and extensive pulmonary invasion of malignant pleural mesothelioma (MPM) in a 70-year-old woman. She first presented with a hydropneumothorax and subsequent workup, including video-assisted thoracoscopy…

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Scientific Reports 2020 October 29 [Link] Sabrina Borchert, Pia-Maria Suckrau, Robert F H Walter, Michael Wessolly, Elena Mairinger, Julia Steinborn, Balazs Hegedus, Thomas Hager, Thomas Herold, Wilfried E E Eberhardt, Jeremias Wohlschlaeger, Clemens Aigner, Agnes Bankfalvi, Kurt Werner Schmid, Fabian D Mairinger Abstract Malignant pleural mesothelioma (MPM) is a rare, but aggressive tumor with dismal…

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EBioMedicine 2020 October 9 [Link] Bill T V Duong, Licun Wu, Brenda J Green, Fatemeh Bavaghar-Zaeimi, Zongjie Wang, Mahmoud Labib, Yuxiao Zhou, Fernando J P Cantu, Thurgaa Jeganathan, Sandra Popescu, Jennifer Pantea, Marc de Perrot, Shana O Kelley Abstract Background: Malignant pleural mesothelioma (MPM) is an aggressive cancer related to asbestos exposure. Early diagnosis is…

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Pharmaceuticals 2020 October 2 [Link] Puey-Ling Chia, Sagun Parakh, Ming-Sound Tsao, Nhu-An Pham, Hui K Gan, Diana Cao, Ingrid J G Burvenich, Angela Rigopoulos, Edward B Reilly, Thomas John, Andrew M Scott Abstract Epidermal growth factor receptor (EGFR) is highly overexpressed in malignant mesothelioma (MM). MAb806 is a novel anti-EGFR antibody that selectively targets a…

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Cytopathology 2020 October 6 [Link] Ben Davidson, Annika Jøntvedt Bock, Arild Holth, Dag Andre Nymoen Abstract Objective: To analyze the expression and clinical role of the phosphatase PTPN1 (PTP1B) in serous effusions. Methods: PTPN1 mRNA expression by quantitative RT-PCR was analyzed in 83 high-grade serous carcinoma (HGSC) and 15 malignant mesothelioma (MM) effusions. PTP1B and…

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Clinical Advances for Hematology and Oncology 2020 September [Link] Joshua E Reuss, Patrick M Forde Abstract Therapeutic advancement for mesothelioma has been stagnant, with minimal treatment innovation in the past decade. Recently, however, immune checkpoint blockade (ICB) targeting the programmed death 1 and cytotoxic T-lymphocyte-associated antigen 4 pathways has revolutionized the treatment of multiple malignancies…

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The Lancet Oncology 2020 October [Link] Aurélien Marabelle, Marwan Fakih, Juanita Lopez, Manisha Shah, Ronnie Shapira-Frommer, Kazuhiko Nakagawa, Hyun Cheol Chung, Hedy L Kindler, Jose A Lopez-Martin, Wilson H Miller Jr, Antoine Italiano, Steven Kao, Sarina A Piha-Paul, Jean-Pierre Delord, Robert R McWilliams, David A Fabrizio, Deepti Aurora-Garg, Lei Xu, Fan Jin, Kevin Norwood, Yung-Jue…

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Journal of Translational Medicine 2020 September 4 [Link] Irene Dell’Anno, Elisa Barone, Luciano Mutti, Doris M Rassl, Stefan J Marciniak, Roberto Silvestri, Stefano Landi, Federica Gemignani Abstract Background: Malignant pleural mesothelioma (MPM) is an aggressive neoplasm of the pleura, mainly related to asbestos exposure. As in other solid tumors, malignant cells exhibit high glucose uptake…

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