Diagnosis & Differentiation
Stem-like exhausted CD8 T cells in pleural effusions predict improved survival in non-small cell lung cancer (NSCLC) and mesothelioma
Translational Lung Cancer Research 2024 September 30 [Link] Linda Ye, Heeju Ryu, David Granadier, Long T Nguyen, Yannick Simoni, Ian Dick, Tina Firth, Ebony Rouse, Peter Chiang, Y C Gary Lee, Bruce W Robinson, Jenette Creaney, Evan W Newell, Alec J Redwood Abstract Background: Anti-tumor CD8 T cells are important for immunity but can become…
Read MoreHigh endothelial venules in the pleura: MECA-79 expression in mesothelioma, pleural metastasis and pleuritis
Pathology, Research, and Practice 2024 November [Link] Ikram Kherrour, Mousa Mobarki, Michel Péoc’h, Georgia Karpathiou Abstract Introduction: High endothelial venules (HEVs) are vessels specialized in the extravasation of lymphocytes from the blood to the tissue implicated in the immune microenvironment of several tumors. Their presence has been never studied in the pleural tissue. Material and…
Read MoreImpact of T Cell Ratios on Survival in Pleural Mesothelioma: Insights from Tumor Microenvironment Analysis
Cancers 2924 October 8 [Link] Laura V Klotz, Andreas Weigert, Florian Eichhorn, Michael Allgäuer, Thomas Muley, Rajiv Shah, Rajkumar Savai, Martin E Eichhorn, Hauke Winter Abstract Background: Immunotherapy has significantly improved overall survival in patients with pleural mesothelioma, yet this benefit does not extend to those with the epithelioid subtype. Tumor growth is believed to…
Read MoreGFPT2: A novel biomarker in mesothelioma for diagnosis and prognosis and its molecular mechanism in malignant progression
British Journal of Cancer 2024 November [Link] Jia Wei, Suiqing Zhou, Gang Chen, Tingting Chen, Yan Wang, Jue Zou, Fang Zhou 6, Jiali Liu, Qixing Gong Abstract Background: Mesothelioma (MESO) is an insidious malignancy with a complex diagnosis and a poor prognosis. Our study unveils Glutamine-Fructose-6-Phosphate Transaminase 2 (GFPT2) as a valuable diagnostic and prognostic…
Read MoreChallenging the Norm: Occurrence of Synchronous Pleural and Peritoneal Mesothelioma in a Female Patient
Cureus 2024 August 18 [Link] Surendar Reddy, Kavya M G, Rakesh Gattu, Alekya P, Manasa Kuthadi Abstract Here, we present a unique case involving a female patient in her 40s with synchronous malignant pleural and peritoneal mesothelioma, despite lacking a history of asbestos exposure. The patient’s initial symptoms included dyspnoea, chest pain, cough, fever, appetite…
Read MoreImmunohistochemical Evaluation of Schlafen 11 (SLFN11) Expression in Cancer in the Search of Biomarker-Informed Treatment Targets: A Study of 127 Entities Represented by 6658 Tumors
The American Journal of Surgical Pathology 2024 August 26 [Link] Maciej Kaczorowski, Kris Ylaya, Małgorzata Chłopek, Daiki Taniyama, Yves Pommier, Jerzy Lasota, Markku Miettinen Abstract Schlafen 11 (SLFN11), a DNA/RNA helicase, acts as a regulator of cellular response to replicative stress and irreversibly triggers replication block and cell death. Several preclinical in vitro studies and…
Read MoreSTK11 (LKB1) immunohistochemistry is a sensitive and specific marker for STK11 adnexal tumours
Histopathology 2024 November [Link] Amir Dehghani, Aarti E Sharma, Stephanie E Siegmund, Chrystalle K Carreon, Colin J R Stewart, Fabiola Medeiros, Jelena Mirkovic, Marisa R Nucci, Christopher P Crum, Jason L Hornick, Brooke E Howitt, W Glenn McCluggage, David L Kolin Abstract Aims: STK11 adnexal tumour is a rare, recently described malignant neoplasm that is…
Read MoreUnleashing precision: A review of targeted approaches in pleural mesothelioma
Critical Reviews in Oncology and Hematology 2024 August 17 [Link] Mario Occhipinti, Marta Brambilla, Raimondo Di Liello, Paolo Ambrosini, Lorenzo Lobianco, Rita Leporati, Maria Salvarezza, Fabiana Vitiello, Silvia Marchesi, Sara Manglaviti, Teresa Beninato, Laura Mazzeo, Claudia Proto, Arsela Prelaj, Roberto Ferrara, Carminia Maria Della Corte, Giuseppe Lo Russo, Filippo de Braud, Monica Ganzinelli, Giuseppe Viscardi…
Read MoreCase report: ATM A1159T mutation in malignant peritoneal mesothelioma may be associated with tumor recurrence
SAGE Open Medical Case Reports 2024 August 16 [Link] Ying Li, Jintao Yang, Bei Zheng, Na Yan, Wenjuan Yang, Xinling Xie, Guoshu Xu, Meiling Zhang Abstract Malignant peritoneal mesothelioma is an exceedingly rare malignant tumor. Herein, we present a case of malignant peritoneal mesothelioma in a 59-year-old Chinese female patient who was stable after treatment…
Read MoreVolatile Organic Compound Analysis of Malignant Pleural Mesothelioma Chorioallantoic Membrane Xenografts
Journal of Breath Research 2024 August 20 [Link] Liam David Little, Sarah E Barnett, Theo Issitt, Sam Bonsall, Vikki Amanda Carolan, K Elizabeth Allen, Laura Margaret Cole, Neil A Cross, Judy M Coulson, Sarah Louise Haywood-Small Abstract Malignant pleural mesothelioma (MPM) is an aggressive cancer associated with asbestos exposure. MPM is often diagnosed late, at…
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