Diagnosis & Differentiation
Matrix Metalloproteinases as Biomarkers and Treatment Targets in Mesothelioma: A Systematic Review
Biomolecules 2021 August 25 [Link] Danijela Štrbac, Vita Dolžan Abstract Metalloproteinases (MMPs) have an important role in tissue remodeling and have been shown to have an effect on tumor progression, invasion, metastasis formation, and apoptosis in several tumors, including mesothelioma. Mesothelioma is a rare tumor arising from pleura and peritoneum and is frequently associated with…
Read MoreIntegrated genomics point to immune vulnerabilities in pleural mesothelioma
Scientific Reports 2021 September 27 [Link] Anca Nastase, Amit Mandal, Shir Kiong Lu, Hima Anbunathan, Deborah Morris-Rosendahl, Yu Zhi Zhang, Xiao-Ming Sun, Spyridon Gennatas, Robert C Rintoul, Matthew Edwards, Alex Bowman, Tatyana Chernova, Tim Benepal, Eric Lim, Anthony Newman Taylor, Andrew G Nicholson, Sanjay Popat, Anne E Willis, Marion MacFarlane, Mark Lathrop, Anne M Bowcock,…
Read MoreFour Immune-Related Genes (FN1, UGCG, CHPF2 and THBS2) as Potential Diagnostic and Prognostic Biomarkers for Carbon Nanotube-Induced Mesothelioma
International Journal of General Medicine 2021 August 29 [Link] Dongli Xie, Jianchen Hu, Tong Wu, Kangli Cao, Xiaogang Luo Abstract Background: Malignant pleural mesothelioma (MPM), a highly aggressive cancer, was mainly attributed to asbestos exposure. Carbon nanotubes (CNTs) share similar negative features to asbestos, provoking concerns about their contribution to MPM. This study was used…
Read MoreMalignant peritoneal mesothelioma: correlation between CT imaging features and histologic subtypes
Abdominal Radiology 2021 August 3 [Link] Isha D Atre, Gaurav V Watane, Mukesh G Harisinghani Abstract Purpose: To identify correlation between CT imaging features and histologic subtypes of Malignant Peritoneal Mesothelioma (MPM). Methods: This was a retrospective single-center study of 51 consecutive patients with the diagnosis of Malignant Peritoneal Mesothelioma (MPM). The tumors were classified…
Read MoreSignificance of p53 immunostaining in mesothelial proliferations and correlation with TP53 mutation status
Modern Pathology 2021 September 8 [Link] Julia R Naso, Basile Tessier-Cloutier, Janine Senz, David G Huntsman, Andrew Churg Abstract p53 immunohistochemistry has long been proposed for the separation of benign from malignant mesothelial proliferations, with the older literature suggesting that any degree of positivity supported a diagnosis of mesothelioma. However, using modern immunohistochemistry platforms in…
Read MoreEvidence-based diagnostic performance of novel biomarkers for the diagnosis of malignant mesothelioma in effusion cytology
Cancer Cytopathology 2021 September 3 [Link] Ilaria Girolami, Ersilia Lucenteforte, Albino Eccher, Stefano Marletta, Matteo Brunelli, Paolo Graziano, Pasquale Pisapia, Umberto Malapelle, Giancarlo Troncone, Aldo Scarpa, Tao Huang, Liron Pantanowitz Abstract Cytology effusions are often the only material available for diagnosing malignant pleural mesothelioma (MPM). However, the cytomorphological features alone are not always diagnostic, and…
Read MoreState of the art cytology of pleural fluid, focusing on the diagnosis of mesothelioma
Cytopathology 2021 September 1 [Link] Sara E Monaco, Luka Brcic, Sanja Dacic Abstract Objective: Mesothelioma has always been a challenging diagnosis to render in body cavity cytology samples. This review is a timely update on pleural fluid cytology and ancillary studies that should be considered in the diagnosis of mesothelial proliferations, specifically mesotheliomas. Methods: Information…
Read MoreLoss of Methylthioadenosine Phosphorylase by Immunohistochemistry Is Common in Pulmonary Sarcomatoid Carcinoma and Sarcomatoid Mesothelioma
American Journal of Clinical Pathology 2021 August 31 [Link] Simone Terra, Anja C Roden 1, Eunhee S Yi, Marie Christine Aubry, Jennifer M Boland Abstract Objectives: Differentiating malignant pleural mesothelioma from benign reactive mesothelial processes can be quite challenging. Ancillary tests such as BRCA1-associated protein 1 (BAP1) immunohistochemistry and p16 fluorescence in situ hybridization (FISH)…
Read MoreSOX6 Expression Is Sensitive for Peritoneal Epithelioid Malignant Mesothelioma, But Not Specific in the Differential Diagnosis With Tubo-ovarian Serous Neoplasia
The American Journal of Surgical Pathology 2021 August 19 [Link] David B Chapel, Michelle S Hirsch Abstract Primary peritoneal malignant mesothelioma (MM) can demonstrate morphologic overlap with low-grade and high-grade tubo-ovarian serous neoplasms; it is also biologically and prognostically distinct from benign mesothelial proliferations. Currently, there is no single biomarker that can definitively distinguish these…
Read MoreIdentification of novel COX-2 / CYP19A1 axis involved in the mesothelioma pathogenesis opens new therapeutic opportunities
Journal of Experimental & Clinical Cancer Research 2021 August 17 [Link] Barbara Nuvoli, Barbara Antoniani, Roberta Libener, Antonio Maconi, Andrea Sacconi, Mariantonia Carosi, Rossella Galati Abstract Background: Based on previous studies highlighting that the induction of cyclooxygenase-2 (COX-2) and high prostaglandin E2 (PGE2) levels contribute to the pathogenesis of malignant pleural mesothelioma (MPM), and that…
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