Diagnosis & Differentiation
Prognostic Significance of B7-H3 Expression and CD163+ Tumor-Associated Macrophage Infiltration in Mesothelioma
International Journal of Molecular Sciences 2026 August 3 [Link] Tülay Koç, Ramazan Oğuz Yüceer, Tuncay Altay, Neslihan Taş, Serkan Çelikgün Abstract Mesothelioma is a rare, aggressive malignancy with poor prognosis. B7-H3 (CD276), an immune checkpoint molecule, and CD163-positive tumor-associated macrophages (TAMs) contribute to tumor progression and immune evasion. This study evaluated the prognostic impact of…
Read MoreLocalized Epithelioid Peritoneal Mesothelioma: A Rare Mimicker of Gynecological Malignancy
Cureus 2026 July 8 [Link] Francisco Carvalho, Daniela Pereira, Teresa Margarida Cunha Abstract Localized epithelioid peritoneal mesothelioma (LEPM) is a rare variant of peritoneal mesothelioma that presents as a solitary, circumscribed mass rather than with the diffuse serosal spread that characterizes the far more common diffuse form. Because it may arise in the pelvis and…
Read MoreInsights Into Genomic Drivers, Transcriptomic Heterogeneity, and Therapeutic Vulnerabilities From Novel Mesothelioma Cell Lines
Thoracic Cancer 2026 August [Link] Yani Wu, Fang Cao, Jiayin Dai, Zhenli Yang, Yanli Zhu, Dongmei Lin, Xiaocui Bian, Yuqin Liu Abstract Background: Pleural mesothelioma (PM) is an aggressive cancer with limited therapeutic options and poor prognosis, necessitating comprehensive model systems for mechanistic studies and drug discovery. Methods: Tumor cells were isolated from malignant pleural…
Read MoreCombined Ultrasound-Guided Thoracentesis, Percutaneous Pleural Biopsy, and Indwelling Pleural Catheter Insertion as the First Intervention in Patients With High Likelihood of Malignant Pleural Effusion
CHEST Pulmonary 2025 July 30 [Link] Michael V Brown, Jelena Solujic, Sarah Yeo, Julia Kim, Phan Nguyen, Arash Badiei Abstract Background: Malignant pleural effusion (MPE) indicates advanced disease and imposes a significant symptomatic burden to patients. Current guidelines recommend stepwise investigation and management. Research question: Is it feasible and safe to combine ultrasound (US)-guided pleural…
Read MoreLow baseline cGAS expression is associated with longer progression-free survival in patients with pleural mesothelioma
Lung Cancer 2026 September [Link] Antoine Torchiat, Karina Silina, Arya Ashok Nair, Laura Viktoria Heeb, Isabelle Opitz, Anurag Gupta, Alessandra Curioni-Fontecedro Abstract Introduction: The cyclic GMP-AMP synthase (cGAS)/STING pathway, a central DNA-sensing mechanism, is known to activate anti-tumor immune response but may also promote tumor progression when chronically activated. Given the role of asbestos-induced chronic…
Read MoreSuccessful Diagnostic Confirmation of Malignant Pleural Mesothelioma With Extensive Pleural Adhesions Using Pleural Cryobiopsy Under Local Anaesthesia
Respirology Case Reports 2026 July 29 [Link] Shotaro Otaki, Mikito Suzuki, Kaito Yano, Tomohiro Imoto, Reiko Shimizu, Tsunekazu Hishima, Kazuo Nakagawa Abstract Local anaesthesia thoracoscopy using flex-rigid thoracoscope is useful for diagnosing pleural lesions, but it is generally not indicated in cases with extensive pleural adhesions. We report a case of malignant pleural mesothelioma (MPM)…
Read MoreSimultaneous Occurrence of Well-Differentiated Papillary Mesothelial Tumor and Multicystic Mesothelioma
Diagnostics 2026 July 15 [Link] Dražen Miličić, Snježana Tomić, Boris Delić, Marko-Dražen Mimica Abstract We report a rare case of simultaneous well-differentiated papillary mesothelial tumor (WDPMT) and multicystic mesothelioma. The concurrent occurrence of these entities is exceptionally uncommon and may pose challenges during surgical intervention. Both lesions are rare mesothelial proliferations that are often identified…
Read MoreGlycan Fingerprint of Malignant Pleural Mesothelioma
International Journal of Molecular Sciences 2026 July 9 [Link] Lovro Kavur, Thomas S Klarić, Nikol Mraz, Nina Šimunić-Briški, Dora Lalić, Gordan Lauc, Martin Martinić, Lovorka Batelja Vuletić, Marina Martinić Kavur, Sven Seiwerth, Ozren Gamulin Abstract Malignant pleural mesothelioma (MPM) is an aggressive pleural tumor associated with asbestos exposure. Poor clinical outcome of MPM is often…
Read MoreEpiproteomic profiling identifies histone H4 hyperacetylation as a prognostic marker in pleural mesothelioma
Lung Cancer 2026 September [Link] Roberta Noberini, Ioanna Bischinioti, Simone Zanetti, Alessandro Vai, Giulia Sedda, Eltjona Mane, Claudia Bardoni, Giulia Robusti, Marianna D’Ercole, Rosanna Mancari, Ugo Cavallaro, Nicoletta Colombo, Luca Bertolaccini, Mariano Lombardi, Nicola Fusco, Lorenzo Spaggiari, Domenico Galetta, Tiziana Bonaldi Abstract Pleural mesothelioma (PM) is an aggressive tumor that arises from mesothelial cells as…
Read MorePrognostic impact of somatic mutations among patients with pleural and peritoneal mesothelioma
NPJ Precision Oncology 2026 July 9 [Link] Justin M Bader, Ankit Dhiman, Nicole Aguirre, Kwasi Ansere Ofori, Princy Gupta, Hannah Qin, Anup Sharma, Owen Mitchell, Melissa Y Tjota, Aliya N Husain, Michael Drazer, Jane Churpek, Hedy Kindler, Kiran Turaga Abstract Mesothelioma is a rare cancer with poor prognosis. Somatic mutations show prognostic value in smaller…
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