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Curated Journal Articles on Mesothelioma

Category Archives: effusion cytology

Cytoplasmic MTAP expression loss detected by immunohistochemistry correlates with 9p21 homozygous deletion detected by FISH in pleural effusion cytology of mesothelioma.

Histopathology 2019 April 8 [Link] Hamasaki M, Kinoshita Y, Yoshimura M, Matsumoto S, Kamei T, Hiroshima K, Sato A, Tsujimura T, Kawahara K, Nabeshima K Abstract Malignant pleural mesothelioma (MPM) is an aggressive neoplasm with poor prognosis. Diagnosis includes verification of mesothelial origin and discrimination of MPM from reactive mesothelial hyperplasia (RMH) or reactive mesothelial […]

April 24, 2019

Biomarkers, effusion cytology, Full Archive, Immunohistochemistry or IHC, Pleural
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What’s new in mesothelioma

Pathologica 2018 March [Link] Ascoli V, Murer B, Nottegar A, Luchini C, Carella R, Calabrese F, Lunardi F, Cozzi I, Righi L Abstract Malignant pleural mesothelioma is a neoplasm characterized by a very poor prognosis and medico-legal implications. Diagnosis, prognosis and therapy are often challenging and include several issues. Cytological diagnosis is frequently the first […]

October 8, 2018

Biomarkers, Biphasic or Mixed, effusion cytology, Epithelioid, Full Archive, Pleural, Sarcomatoid
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A second case of pericardial mesothelioma mimicking systemic lupus erythematosus in the literature in over 30 years: a case report

Journal of Medical Case Reports 2017 March 29 [Link] Mensi C, Romano A, Berti A, Dore R, Riboldi L Abstract BACKGROUND: Mesothelioma is a rare neoplasm which commonly develops in the pleura of people exposed to asbestos. Pericardial mesothelioma accounts for only 0.7 % of all malignant mesotheliomas and it usually presents with pericardial effusion, […]

April 5, 2017

CT or CAT scan, effusion cytology, Full Archive, Pericardial
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The importance of EZH2 and MOC-31 expression in the differential diagnosis of benign and malignant effusions

Diagnostic Cytopathology 2016 December 26 [Epub ahead of print] [Link] Sadullahoglu C, Nart D, Veral A Abstract BACKGROUND: All malignant tumors may spread throughout the pleural, peritoneal, and pericardial cavities. The presence of tumor cells in serosal fluid is a poor prognostic indicator. It may be difficult to differentiate nuclear atypia of mesothelial cells due […]

January 5, 2017

effusion cytology, Epithelioid, Immunohistochemistry or IHC, Pericardial, Peritoneal (Abdominal Mesothelioma), Pleural
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CD24 is highly useful in differentiating high-grade serous carcinoma from benign and malignant mesothelial cells

Human Pathology 2016 August 30 [Epub ahead of print] [Link] Davidson B Abstract CD24 was previously shown to be overexpressed in high-grade serous carcinoma (HGSC) effusions compared to malignant mesothelioma (MM) in gene expression array analysis. The present study validated this observation in a large series consisting of both effusions and surgical specimens. Effusions (n=206; […]

September 7, 2016

Biomarkers, effusion cytology, Immunohistochemistry or IHC, Pleural Effusion, Surgery
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Common Fluorescence In Situ Hybridization Applications in Cytology

Archives of Pathology & Laboratory Medicine 2016 August 4 [Epub ahead of print] [Link] Savic S, Bubendorf L Abstract CONTEXT: -Fluorescence in situ hybridization (FISH) is a well-established method for detection of genomic aberrations in diagnostic, prognostic, and predictive marker testing. OBJECTIVE: -To review common applications of FISH in cytology. DATA SOURCES: -The published literature […]

August 14, 2016

Diagnosis & Differentiation, effusion cytology, EGFR, Kinase Inhibitors
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Biphasic effects of l-ascorbate on the tumoricidal activity of non-thermal plasma against malignant mesothelioma cells

Archives of Biochemistry and Biophysics 2016 May 24 [Epub ahead of print] [Link] Shi L, Wang Y, Ito F, Okazaki Y, Tanaka H, Mizuno M, Hori M, Richardson DR, Toyokuni S. Abstract Non-thermal plasma (NTP) is a recently developed technology that elicits a variety of biological effects. This includes cancer cell-specific cytotoxicity, which is mainly […]

June 4, 2016

Determining Efficacy, effusion cytology, Non-thermal Plasma (NTP), Pleural
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BAP1 Immunostain and CDKN2A (p16) FISH Analysis: Clinical Applicability for the Diagnosis of Malignant Mesothelioma in Effusions

Diagnostic cytopathology 2016 April 28 [Epub ahead of print] [Link] Walts AE, Hiroshima K, McGregor SM, Wu D, Husain AN, Marchevsky AM. Abstract BACKGROUND: Loss of BAP1 by immunohistochemistry (IHC) and CDKN2A(p16) deletion by fluorescence in situ hybridization (FISH) have been proposed to distinguish malignant mesothelioma (MM) from atypical reactive mesothelial proliferations (ARMP) in effusions but […]

May 8, 2016

Biomarkers, Determining Efficacy, Diagnosis & Differentiation, effusion cytology, Full Archive, Immune-based Therapies, Immunohistochemistry or IHC
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Young investigator challenge: MicroRNA-21/MicroRNA-126 profiling as a novel tool for the diagnosis of malignant mesothelioma in pleural effusion cytology

Cancer Cytopathology 2016 January [Epub ahead of print] [Link] Cappellesso R, Nicolè L, Caroccia B, Guzzardo V, Ventura L, Fassan M, Fassina A. Abstract Background In pleural effusion cytology, the distinction of malignant mesothelioma (MM) from reactive mesothelial cells (RMCs) may be challenging, even with the aid of immunocytochemistry or fluorescence in situ hybridization. It […]

January 22, 2016

Diagnosis & Differentiation, effusion cytology, Full Archive, Pleural, Type of Assessment:
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Guidelines for cytopathologic diagnosis of epithelioid and mixed type malignant mesothelioma. Complementary statement from the International Mesothelioma Interest Group, also endorsed by the International Academy of Cytology and the Papanicolaou Society of Cytopathology

Cytojournal 2015 November 30 [Link] Hjerpe A, Ascoli V, Bedrossian C, Boon M, Creaney J, Davidson B, Dejmek A, Dobra K, Fassina A, Field A, Firat P, Kamei T, Kobayashi T, Michael CW, Önder S, Segal A, Vielh P. Abstract To provide practical guidelines for the cytopathologic diagnosis of malignant mesothelioma (MM). Cytopathologists involved in […]

January 4, 2016

Diagnosis & Differentiation, effusion cytology, Full Archive, Type of Assessment:
Comments Off on Guidelines for cytopathologic diagnosis of epithelioid and mixed type malignant mesothelioma. Complementary statement from the International Mesothelioma Interest Group, also endorsed by the International Academy of Cytology and the Papanicolaou Society of Cytopathology