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Curated Journal Articles on Mesothelioma

Category Archives: effusion cytology

Genomic-based Ancillary Assays Offer Improved Diagnostic Yield of Effusion Cytology With Potential Challenges in Malignant Pleural Mesothelioma

Pathology International 2020 June 15 [Link] Yoshiaki Kinoshita, Makoto Hamasaki, Shinji Matsumoto, Masayo Yoshimura, Ayuko Sato, Tohru Tsujimura, Toshiaki Kamei, Kunimitsu Kawahara, Kazuki Nabeshima Abstract BRCA1-associated protein 1 (BAP1) or methylthioadenosine phosphorylase (MTAP) immunohistochemistry (IHC) or 9p21 fluorescence in situ hybridization (FISH) are useful for the diagnosis of malignant pleural mesothelioma (MPM). However, the effect […]

June 29, 2020

effusion cytology, Full Archive, Immunohistochemistry or IHC, Pleural, Pleural Effusion
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HEG1, BAP1, and MTAP Are Useful in Cytologic Diagnosis of Malignant Mesothelioma With Effusion

Diagnostic Cytopathology 2020 May 22 [Link] Kenzo Hiroshima, Di Wu, Shinji Hamakawa, Shingo Tsuruoka, Daisuke Ozaki, Hideki Orikasa, Mizue Hasegawa, Eitetsu Koh, Yasuo Sekine, Yoko Yonemori, Kazuki Nabeshima, Shoutaro Tsuji, Yohei Miyagi, Kohzoh Imai Abstract Background: The specificity and sensitivity of HEG1 for malignant mesothelioma (MM) is high. The use of BAP1/MTAP immunohistochemistry (IHC) is […]

June 1, 2020

effusion cytology, Full Archive, Immunohistochemistry or IHC, Pleural, Pleural Effusion
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Effusion cytology of malignant mesothelioma enables earlier diagnosis and recognizes patients with better prognosis.

Diagnostic Cytopathology 2020 February 20 [Link] Abd Own S, Höijer J, Hillerdahl G, Dobra K, Hjerpe A Abstract A conclusive diagnosis of malignant mesothelioma (MM) can be based on effusion cytology using the guidelines for the cytopathologic diagnosis of epithelioid and mixed-type MM. Briefly, the diagnosis is obtained when the mesothelial phenotype of malignant cells […]

February 20, 2020

Biphasic or Mixed, Chemotherapy, CT or CAT scan, effusion cytology, Epithelioid, Full Archive, Pleural Effusion
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Cytoplasmic MTAP expression loss detected by immunohistochemistry correlates with 9p21 homozygous deletion detected by FISH in pleural effusion cytology of mesothelioma.

Histopathology 2019 April 8 [Link] Hamasaki M, Kinoshita Y, Yoshimura M, Matsumoto S, Kamei T, Hiroshima K, Sato A, Tsujimura T, Kawahara K, Nabeshima K Abstract Malignant pleural mesothelioma (MPM) is an aggressive neoplasm with poor prognosis. Diagnosis includes verification of mesothelial origin and discrimination of MPM from reactive mesothelial hyperplasia (RMH) or reactive mesothelial […]

April 24, 2019

Biomarkers, effusion cytology, Full Archive, Immunohistochemistry or IHC, Pleural
Comments Off on Cytoplasmic MTAP expression loss detected by immunohistochemistry correlates with 9p21 homozygous deletion detected by FISH in pleural effusion cytology of mesothelioma.

What’s new in mesothelioma

Pathologica 2018 March [Link] Ascoli V, Murer B, Nottegar A, Luchini C, Carella R, Calabrese F, Lunardi F, Cozzi I, Righi L Abstract Malignant pleural mesothelioma is a neoplasm characterized by a very poor prognosis and medico-legal implications. Diagnosis, prognosis and therapy are often challenging and include several issues. Cytological diagnosis is frequently the first […]

October 8, 2018

Biomarkers, Biphasic or Mixed, effusion cytology, Epithelioid, Full Archive, Pleural, Sarcomatoid
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A second case of pericardial mesothelioma mimicking systemic lupus erythematosus in the literature in over 30 years: a case report

Journal of Medical Case Reports 2017 March 29 [Link] Mensi C, Romano A, Berti A, Dore R, Riboldi L Abstract BACKGROUND: Mesothelioma is a rare neoplasm which commonly develops in the pleura of people exposed to asbestos. Pericardial mesothelioma accounts for only 0.7 % of all malignant mesotheliomas and it usually presents with pericardial effusion, […]

April 5, 2017

CT or CAT scan, effusion cytology, Full Archive, Pericardial
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The importance of EZH2 and MOC-31 expression in the differential diagnosis of benign and malignant effusions

Diagnostic Cytopathology 2016 December 26 [Epub ahead of print] [Link] Sadullahoglu C, Nart D, Veral A Abstract BACKGROUND: All malignant tumors may spread throughout the pleural, peritoneal, and pericardial cavities. The presence of tumor cells in serosal fluid is a poor prognostic indicator. It may be difficult to differentiate nuclear atypia of mesothelial cells due […]

January 5, 2017

effusion cytology, Epithelioid, Immunohistochemistry or IHC, Pericardial, Peritoneal (Abdominal Mesothelioma), Pleural
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CD24 is highly useful in differentiating high-grade serous carcinoma from benign and malignant mesothelial cells

Human Pathology 2016 August 30 [Epub ahead of print] [Link] Davidson B Abstract CD24 was previously shown to be overexpressed in high-grade serous carcinoma (HGSC) effusions compared to malignant mesothelioma (MM) in gene expression array analysis. The present study validated this observation in a large series consisting of both effusions and surgical specimens. Effusions (n=206; […]

September 7, 2016

Biomarkers, effusion cytology, Immunohistochemistry or IHC, Pleural Effusion, Surgery
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Common Fluorescence In Situ Hybridization Applications in Cytology

Archives of Pathology & Laboratory Medicine 2016 August 4 [Epub ahead of print] [Link] Savic S, Bubendorf L Abstract CONTEXT: -Fluorescence in situ hybridization (FISH) is a well-established method for detection of genomic aberrations in diagnostic, prognostic, and predictive marker testing. OBJECTIVE: -To review common applications of FISH in cytology. DATA SOURCES: -The published literature […]

August 14, 2016

Diagnosis & Differentiation, effusion cytology, EGFR, Kinase Inhibitors
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Biphasic effects of l-ascorbate on the tumoricidal activity of non-thermal plasma against malignant mesothelioma cells

Archives of Biochemistry and Biophysics 2016 May 24 [Epub ahead of print] [Link] Shi L, Wang Y, Ito F, Okazaki Y, Tanaka H, Mizuno M, Hori M, Richardson DR, Toyokuni S. Abstract Non-thermal plasma (NTP) is a recently developed technology that elicits a variety of biological effects. This includes cancer cell-specific cytotoxicity, which is mainly […]

June 4, 2016

Determining Efficacy, effusion cytology, Non-thermal Plasma (NTP), Pleural
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