Effusion Cytology
Diagnostic capacity of BAP1 and MTAP in cytology from effusions and biopsy in mesothelioma
Journal of the American Society of Cytopathology 2022 July 9 [Link] Louise Andersen Lynggård, Vasiliki Panou, Weronika Szejniuk, Oluf Dimitri Røe, Christos Meristoudis Abstract Introduction: Serous effusion is often the first sign of mesothelioma. Diagnosis based on cytologic material from the effusions remains controversial and complementary biopsy is usually required. However, obtaining representative tissue sample…
Read MoreClinical significance of 9P21 gene combined with BAP1 and MTAP protein expression in diagnosis and prognosis of mesothelioma serous effusion
Biomedical Reports 2022 June 7 [Link] Guan-Ying Ma, Shuai Shi, Ping Wang, Xing-Guang Wang, Zhi-Gang Zhang Abstract The diagnostic value of the 9P21 gene determined using fluorescence in situ hybridization (FISH) combined with BRCA1-associated protein 1 (BAP1) and methylthioadenosine phosphorylase (MTAP) expression detection by immunohistochemistry, was investigated in serous effusion samples of malignant mesothelioma. A…
Read MoreUpdate of pathological diagnosis of pleural mesothelioma using genomic-based morphological techniques, for both histological and cytological investigations
Pathology International 2022 May 21 [Link] Kazuki Nabeshima, Makoto Hamasaki, Yoshiaki Kinoshita, Shinji Matsumoto, Prakasit Sa-Ngiamwibool Abstract As more than 80% of pleural mesothelioma (PM) cases start with pleural effusions, diagnosis with effusion smear cytology or pleural biopsy is important. For diagnosing PM, a three-step approach is used: (1) detecting atypical cells; (2) verifying their…
Read MoreEvaluation of pleural fluid cytology for the diagnosis of malignant pleural effusion: a retrospective cohort study
Internal Medicine Journal 2022 February 21 [Link] L Pairman, Lel Beckert, M Dagger, M J Maze Abstract Background: Cytological examination of pleural fluid has a good specificity but imperfect sensitivity for the diagnosis of malignant pleural effusion (MPE). Published estimates of sensitivity vary and predictors of false negative cytology are not well established. We aimed…
Read MoreAnalysis of early pleural fluid samples in patients with mesothelioma: A case series exploration of morphology, BAP1, and CDKN2A status with implications for the concept of mesothelioma in situ in cytology
Cancer Cytopathology 2022 February 10 [Link] Amber Louw, Chris van Vliet, Joanne Peverall, Shane Colkers, Nathan Acott, Jenette Creaney, Y C Gary Lee, Siaw Ming Chai Abstract Background: The concept of mesothelioma in situ has been revisited and is a new World Health Organization diagnostic entity. The definition centers on ancillary techniques used in pleural…
Read MoreThe highlights of the 15th international conference of the international mesothelioma interest group – Do molecular concepts challenge the traditional approach to pathological mesothelioma diagnosis?
Lung Cancer 2021 November 6 [Link] Sonja Klebe, Francoise Galateau Salle, Rossella Bruno, Luka Brcic, Heather I Chen-Yost, Marie-Claude Jaurand Abstract Pathology plays an important role in diagnosing mesothelioma since radiological and clinical findings alone cannot distinguish mesothelioma reliably from its many mimics. The long-held gold standard for pathological diagnosis requires a tissue biopsy that,…
Read MoreCytological Diagnostic Procedures in Malignant Mesothelioma
Advances in Experimental Medicine and Biology 2021 November 18 [Link] Christian Biancosino, Lea Isabell Shari van der Linde, Guido Sauter, Florian Stellmacher, Marcus Krüger, Lutz Welker Abstract Malignant mesotheliomas (MM) are rare tumors with high mortality rates, whose incidence varies regionally and nationally, and the diagnosis is difficult. Histology-based diagnosis is considered the gold standard…
Read MoreEvidence-based diagnostic performance of novel biomarkers for the diagnosis of malignant mesothelioma in effusion cytology
Cancer Cytopathology 2021 September 3 [Link] Ilaria Girolami, Ersilia Lucenteforte, Albino Eccher, Stefano Marletta, Matteo Brunelli, Paolo Graziano, Pasquale Pisapia, Umberto Malapelle, Giancarlo Troncone, Aldo Scarpa, Tao Huang, Liron Pantanowitz Abstract Cytology effusions are often the only material available for diagnosing malignant pleural mesothelioma (MPM). However, the cytomorphological features alone are not always diagnostic, and…
Read MoreState of the art cytology of pleural fluid, focusing on the diagnosis of mesothelioma
Cytopathology 2021 September 1 [Link] Sara E Monaco, Luka Brcic, Sanja Dacic Abstract Objective: Mesothelioma has always been a challenging diagnosis to render in body cavity cytology samples. This review is a timely update on pleural fluid cytology and ancillary studies that should be considered in the diagnosis of mesothelial proliferations, specifically mesotheliomas. Methods: Information…
Read MoreThe value of cytology in distinguishing malignant mesothelioma: An institutional experience of 210 cases reclassified according to the International System for Reporting Serous Fluid Cytopathology (ISRSFC)
Cytopathology 2021 May 28 [Link] Patrizia Straccia, Daniele Magnini, Rocco Trisolini, Filippo Lococo, Marco Chiappetta, Alessandra Cancellieri Abstract Objective: Malignant mesothelioma (MM) is usually diagnosed by histological examination of tissue samples; however, effusion cytology offers an opportunity to identify a strong possibility for mesothelioma diagnosis at an early stage. We conducted a retrospective analysis of…
Read More