Raltitrexed (Tomudex)
Kdm6a and Kdm6b: Altered expression in malignant pleural mesothelioma
International Journal of Oncology 2017 February 9 [Epub ahead of print] [Link] Cregan S, Breslin M, Roche G, Wennstedt S, MacDonagh L, Albadri C, Gao Y, O’Byrne KJ, Cuffe S, Finn SP, Gray SG Abstract Malignant pleural mesothelioma (MPM) is a rare aggressive cancer of the pleura primarily associated with prior exposure to asbestos. The…
Read MoreImpact of New Chemotherapeutic agents on the outcome of Egyptian patients with Advanced Malignant Pleural Mesothelioma
The Gulf Journal of Oncology 2014 July [Link] Gaafar P, Sallam YA, Shafik HE, Aboulkassem FA, Emara M, Khaled H. Abstract Patients with malignant pleural mesothelioma (MPM) are well known to have poor response to chemotherapy. Aim of this work was to evaluate the efficacy and safety of new chemotherapeutic agents for the treatment of…
Read MoreMesothelioma: treatment
Revue des Maladies Respiratoires. 2008 Oct;25(8 Pt 2):3S191-5. [Link] Berghmans T. Département des Soins Intensifs et Oncologie Thoracique, Institut Jules-Bordet (Centre des Tumeurs de l’Université Libre de Bruxelles), 1 Rue Héger-Bordet, Brussels, Belgium. thierry.berghmanns@bordet.be Abstract Malignant pleural mesothelioma is a rare tumour of poor prognosis. Available therapeutics have restricted efficacy. Pleuro-pneumonectomy is the only treatment…
Read MoreSystemic Treatments for Mesothelioma: Standard and Novel
Current Treatment Options in Oncology. 2008 Jun;9(2-3):171-9. Epub 2008 Sep 3. [Link] Kindler HL. Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA. hkindler@medicine.bsd.uchicago.edu Abstract Systemic therapy is the only treatment option for the majority of mesothelioma patients, for whom age, co-morbid medical illnesses, non-epithelial histology, and locally advanced disease often preclude surgery. For…
Read MoreSymptoms and patient-reported well-being: do they predict survival in malignant pleural mesothelioma? A prognostic factor analysis of EORTC-NCIC 08983: randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma
Journal of Clinical Oncology. 2007 Dec 20;25(36):5770-6. [Link] Bottomley A, Coens C, Efficace F, Gaafar R, Manegold C, Burgers S, Vincent M, Legrand C, van Meerbeeck JP; EORTC-NCIC. EORTC Data Center, Quality of Life Unit, Avenue E. Mounier, 83, 1200 Brussels, Belgium. andrew.bottomley@eortc.be Abstract Purpose: Malignant pleural mesothelioma (MPM) is a rare disease. Unlike other…
Read MoreMultidisciplinary Treatment of Malignant Pleural Mesothelioma
The Oncologist. 2007 Jul;12(7):850-63. [Link] Ceresoli GL, Gridelli C, Santoro A. Dipartimento di Oncologia Medica e Ematologia, Istituto Clinico Humanitas IRCCS, Via Manzoni, Rozzano (MI), Italy. giovanni_luca.ceresoli@humanitas.it Abstract The incidence of malignant pleural mesothelioma (MPM) is increasing worldwide, and is predicted to peak in the next 10-20 years. Difficulties in MPM diagnosis and staging, especially…
Read MoreThe use of chemotherapy in patients with advanced malignant pleural mesothelioma: a systematic review and practice guideline
Journal of Thoracic Oncology. 2006 Jul;1(6):591-601. [Link] Ellis P, Davies AM, Evans WK, Haynes AE, Lloyd NS; Lung Cancer Disease Site Group of Cancer Care Ontario’s Program in Evidence-based Care. McMaster University at Hamilton Health Sciences and Juravinski Cancer Centre, Hamilton, Ontario, Canada. vanderja@mcmaster.ca Abstract Background: This clinical practice guideline, based on a systematic review,…
Read MoreShort-Term Treatment-Related Symptoms and Quality of Life: Results From an International Randomized Phase III Study of Cisplatin With or Without Raltitrexed in Patients With Malignant Pleural Mesothelioma: An EORTC Lung-Cance
Journal of Clinical Oncology. 2006 Jan 30; [Epub ahead of print]. [Link] Bottomley A, Gaafa R, Manegold C, Burgers S, Coens C, Legrand C, Vincent M, Giaccone G, Van Meerbeeck J. European Organisation for Research and Treatment of Cancer, EORTC Data Center, Brussels; University Hospital, Ghent, Belgium; National Cancer Center, Cairo, Egypt; Thoraxklinik Heidelberg, Germany;…
Read MoreMesothelioma: advances in chemotherapy
Revue des Maladies Respiratoire. 2005 Dec;22(6-C2):49-54. [Link] Jacoulet P. Service de Pneumologie, CHU, Besancon, France. Abstract Chemotherapy is often the only treatment possible for locally advanced or metastatic mesothelioma. This paper recalls which drugs might have therapeutic benefits in this condition and reviews recent studies of chemotherapy or targeted therapy. If the patient cannot be…
Read MoreRandomized Phase III Study of Cisplatin With or Without Raltitrexed in Patients With Malignant Pleural Mesothelioma
An Intergroup Study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada Journal of Clinical Oncology. Vol 23, No 28 (October 1), 2005: pp. 6881-6889 [Link] Jan P. van Meerbeeck, Rabab Gaafar, Christian Manegold, Rob J. Van Klaveren, Eric A. Van Marck, Mark Vincent,…
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