Environmental Asbestos Exposure
Evaluation of respiratory toxicity and peritoneal mesothelioma induced by heat-treated and milled amosite following intratracheal and intraperitoneal injection in rats
Industrial Health 2026 January 29 [Link] Hiroshi Yamauchi, Ayako Takata, Kiyotsugu Yamashita, Masahito Aminaka, Toshiaki Hitomi, Norihiko Kohyama Abstract Amoste is highly carcinogenic, and its incomplete removal from the environment continues to pose significant health risks. High temperatures are known to alter the crystal structure of asbestos. In this study, we evaluated the carcinogenicity and…
Read MoreThe Accuracy of Video-Assisted Thoracic Surgery Pleural Biopsy in Patients with Suspected Diffuse Pleural Mesothelioma: A Real-Life Study
Journal of Clinical Medicine 2025 December 20 [Link] Ludovica Balsamo, Enrica Migliore, Eleonora Della Beffa, Luisa Delsedime, Paolo Olivo Lausi, Daniela Di Cuonzo, Filippo Lococo, Paraskevas Lyberis, Dario Mirabelli, Mauro Giulio Papotti, Enrico Ruffini, Francesco Guerrera Abstract Background: The heritage of occupational and environmental asbestos exposure in Piedmont, Italy, has resulted in an enduring diffuse…
Read MoreLong-term survival of nonoccupational pleural mesothelioma: a case report and review of the literature
Journal of Medical Case Reports 2025 October 21 [Link] Loreta Tobia, Elio Tolli, Adalgisa Ilaria Sedile, Vincenza Cofini, Stefano Necozione, Leila Fabiani Abstract Introduction: Malignant mesothelioma is an aggressive cancer that arises from the mesothelial cells lining the pleura, peritoneum, pericardium, or tunica vaginalis. While occupational exposure accounts for most cases, nonoccupational exposures (to ionizing…
Read MoreContemporary management of mesothelioma
Breathe 2024 July 16 [Link] Mark D J Neilly, Jennifer Pearson, Akari Win Thu, Carolyn MacRae, Kevin G Blyth Abstract Pleural mesothelioma (PM) is an aggressive asbestos-associated thoracic malignancy with a median survival of 12-18 months. Due to continued asbestos use in many nations, global incidence is rising. Causes due to non-occupational, environmental exposure are…
Read MorePreventive and therapeutic opportunities: targeting BAP1 and/or HMGB1 pathways to diminish the burden of mesothelioma
Journal of Translational Medicine 2023 October 25 [Link] Michele Carbone, Michael Minaai, Yasutaka Takinishi, Ian Pagano, Haining Yang Abstract Mesothelioma is a cancer typically caused by asbestos. Mechanistically, asbestos carcinogenesis has been linked to the asbestos-induced release of HMGB1 from the nucleus to the cytoplasm, where HMGB1 promotes autophagy and cell survival, and to the…
Read MoreExpression of stathmin in asbestos-like fibers-induced mesothelioma: A preliminary report
Histology and Histopathology 2023 June 30 [Link] Claudia Lombardo, Giuseppe Broggi, Ermanno Vitale, Caterina Ledda, Carla Loreto, Serena Matera, Maria Hagnas, Rosario Caltabiano, Veronica Filetti Abstract Background: Mesothelioma is strongly associated with exposure to asbestos fibers, however, recent studies have also linked exposure to “naturally occurring asbestos” fibers with this disease. Fluoro-edenite, a silicate mineral…
Read MoreGenetic analysis of familial predisposition in the pathogenesis of malignant pleural mesothelioma
Journal of Cancer Research and Clinical Oncology 2023 April 7 [Link] Muhittin Akarsu, Güntülü Ak, Emine Dündar, Muzaffer Metintaş Abstract Purpose: Mesothelioma is the primary tumor of the mesothelial cell membrane. The most important etiology is asbestos exposure. The development of malignant mesothelioma in very few of the population exposed to asbestos and its frequent…
Read MoreAssociation of mesothelioma deaths with neighborhood asbestos exposure due to a large-scale asbestos-cement plant
Cancer Science 2023 April 3 [Link] Yuri Kitamura, Ling Zha, Rong Liu, Masayuki Shima, Tomoki Nakaya, Norio Kurumatani, Shinji Kumagai, Junko Goji, Tomotaka Sobue Abstract A causal relationship between mesothelioma and occupational asbestos exposure is well known, while some studies have shown a relationship to non-occupational exposures. The aim of this study was to quantify…
Read MoreSmall RNA-Seq Transcriptome Profiling of Mesothelial and Mesothelioma Cell Lines Revealed microRNA Dysregulation after Exposure to Asbestos-like Fibers
Biomedicines 2023 February 13 [Link] Veronica Filetti, Claudia Lombardo, Carla Loreto, George Dounias, Massimo Bracci, Serena Matera, Lucia Rapisarda, Venerando Rapisarda, Caterina Ledda, Ermanno Vitale Abstract Environmental exposure to fibers of respirable size has been identified as a risk for public health. Experimental evidence has revealed that a variety of fibers, including fluoro-edenite, can develop…
Read MoreJourney to the centre of the lung. The perspective of a mineralogist on the carcinogenic effects of mineral fibres in the lungs
Journal of Hazardous Materials 2023 January 15 [Link] Alessandro F Gualtieri Abstract This work reviews the bio-chemical mechanisms leading to adverse effects produced when mineral fibres are inhaled and transported in the lungs from the perspective of a mineralogist. The behaviour of three known carcinogenic mineral fibres (crocidolite, chrysotile, and fibrous-asbestiform erionite) during their journey…
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