Frontiers in Oncology 2021 March 22 [Link] Federica Pezzuto, Francesca Lunardi, Luca Vedovelli, Francesco Fortarezza, Loredana Urso, Federica Grosso, Giovanni Luca Ceresoli, Izidor Kern, Gregor Vlacic, Eleonora Faccioli, Marco Schiavon, Dario Gregori, Federico Rea, Giulia Pasello, Fiorella Calabrese Abstract Introduction: The CDKN2A gene plays a central role in the pathogenesis of malignant pleural mesothelioma (MPM).…

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Cancers 2021 March 29 [Link] Haitang Yang, Sean R R Hall, Beibei Sun, Liang Zhao, Yanyun Gao, Ralph A Schmid, Swee T Tan, Ren-Wang Peng, Feng Yao Abstract (1) Inactivation of the tumor suppressor NF2 is believed to play a major role in the pathogenesis of malignant pleural mesothelioma (MPM) by deregulating the Hippo-YAP signaling…

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Lung Cancer 2021 January 14 [Link] Sharyn I Katz, Leonid Roshkovan, Ian Berger, Joseph S Friedberg, Evan W Alley, Charles B Simone 2nd, Andrew R Haas, Keith A Cengel, Daniel H Sterman, Steven M Albelda Abstract Objectives: Soluble mesothelin-related protein (SMRP) and fibulin-3 serum levels may serve as diagnostic and prognostic biomarkers of malignant pleural…

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European Journal of Cancer 2020 December 13 [Link] Luca Cantini, Federica Pecci, Daan P Hurkmans, Robert A Belderbos, Andrea Lanese, Cecilia Copparoni, Sophie Aerts, Robin Cornelissen, Daphne W Dumoulin, Ilaria Fiordoliva, Silvia Rinaldi, Joachim G J V Aerts, Rossana Berardi Abstract Background: In preclinical models, statins showed vaccine adjuvant activities and synergized with PD-1 inhibitors.…

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Clinical Advances for Hematology and Oncology 2020 September [Link] Joshua E Reuss, Patrick M Forde Abstract Therapeutic advancement for mesothelioma has been stagnant, with minimal treatment innovation in the past decade. Recently, however, immune checkpoint blockade (ICB) targeting the programmed death 1 and cytotoxic T-lymphocyte-associated antigen 4 pathways has revolutionized the treatment of multiple malignancies…

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Cancers 2020 September 25 [Link] Wei Song, Hao Wang, Minmin Lu, Xinxin Ni, Nacef Bahri, Shuihao Zhu, Limin Chen, Yuehong Wu, Jieqiong Qiu, Jonathan A Fletcher, Wen-Bin Ou Abstract Malignant mesothelioma is a locally aggressive and highly lethal neoplasm. Dysregulation and activation of Gas6/AXL tyrosine kinase signaling are associated with mesothelioma progression, but the mechanisms…

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Annals of Oncology 2020 September 22 [Link] S Popat, A Curioni-Fontecedro, U Dafni, R Shah, M O’Brien, A Pope, P Fisher, J Spicer, A Roy, D Gilligan, O Gautschi, E Nadal, W D Janthur, R López Castro, R García Campelo, S Rusakiewicz, I Letovanec, V Polydoropoulou, H Roschitzki-Voser, B Ruepp, A Gasca-Ruchti, S Peters, R…

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Journal of Immunology 2020 September 18 [Link] Mikihiro Kohno, Junichi Murakami, Licun Wu, Mei-Lin Chan, Zhihong Yun, B C John Cho, Marc de Perrot Abstract Increasing evidence indicates that local hypofractionated radiotherapy (LRT) can elicit both immunogenic and immunosuppressive local and systemic immune responses. We thus hypothesized that blockade of LRT-induced immunosuppressive responses could augment…

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Cancer 2020 September 1 [Link] Raffit Hassan, Christine Alewine, Idrees Mian, Anna Spreafico, Lillian L Siu, Carlos Gomez-Roca, Jean-Pierre Delord, Antoine Italiano, Ulrik Lassen, Jean-Charles Soria, Rastilav Bahleda, Anish Thomas, Seth M Steinberg, Cody J Peer, William D Figg, Gerhard Niederfellner, Valérie Méresse Naegelen, Ira Pastan Abstract Background: LMB-100 is an antibody-toxin conjugate with an…

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