Isolation and whole genomic analysis of mesophilic bacterium Pseudoglutamicibacter cumminsii in epithelial mesothelioma

Heliyon 2024 August 2 [Link] Nan Xu, Kunyi Wu, Ting La, Bo Cao Abstract The relationship between bacteria and tumors has been the hot spot of clinical research in recent years. Pseudoglutamicibacter cumminsii is an aerobic Gram-positive bacterium commonly found in soil. Recent studies have identified P. cumminsii in patients with cutaneous and urinary tract…

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Volatile Organic Compound Analysis of Malignant Pleural Mesothelioma Chorioallantoic Membrane Xenografts

Journal of Breath Research 2024 August 20 [Link] Liam David Little, Sarah E Barnett, Theo Issitt, Sam Bonsall, Vikki Amanda Carolan, K Elizabeth Allen, Laura Margaret Cole, Neil A Cross, Judy M Coulson, Sarah Louise Haywood-Small Abstract Malignant pleural mesothelioma (MPM) is an aggressive cancer associated with asbestos exposure. MPM is often diagnosed late, at…

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Integration of the PD-L1 inhibitor atezolizumab and WT1/DC vaccination into standard-of-care first-line treatment for patients with epithelioid malignant pleural mesothelioma-Protocol of the Immuno-MESODEC study

PloS One 2024 July 15 [Link] Jolien Van den Bossche, Maxime De Laere, Koen Deschepper, Paul Germonpré, Yvan Valcke, Jan Lamont, Barbara Stein, Kirsten Van Camp, Charlotte Germonpré, Griet Nijs, Ella Roelant, Sébastien Anguille, Eva Lion, Zwi Berneman Abstract Malignant pleural mesothelioma (MPM) is an aggressive cancer with a very poor prognosis. Recently, immune checkpoint…

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A Rare Case of Pleural Epithelioid Mesothelioma With a Prominent Myxoid Stroma Reported With Morphology, Fluorescent In Situ Hybridization, and Ultrastructural Findings

Cureus 2024 June 12 [Link] Hiroshi Sonobe, Rika Omote, Toshiyuki Habara, Kazuhiro Washio, Nobuyoshi Yamazoe, Shinji Matsumoto, Kazuki Nabeshima, Hiroko Toda Abstract Herein, we report a rare case of pleural epithelioid malignant mesothelioma with a prominent myxoid stroma. To date, detailed morphological or molecular pathological findings have not been reported for this type of tumor.…

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Real-World efficacy and safety of combination nivolumab plus ipilimumab for Untreated, Unresectable, pleural Mesothelioma: The Meso-Immune (GFPC 04-2021) trial

Lung Cancer 2024 June 29 [Link] Olivier Bylicki, Florian Guisier, Arnaud Scherpereel, Catherine Daniel, Aurélie Swalduz, Emmanuel Grolleau, Marie Bernardi, Stephane Hominal, Jean Briac Prevost, Guillaume Pamart, Marie Héléne Marques, Nicolas Cloarec, Simon Deshayes, Judith Raimbourg, Rémi Veillon, Youssef Oulkhouir, Clarisse Audigier Valette, Fabien Subtil, Christos Chouaïd, Laurent Greillier Abstract Background: First-line standard-of-care for unresectable,…

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Single cell view of tumor microenvironment gradients in pleural mesothelioma

Cancer Discovery 2024 July 5 [Link] Bruno Giotti, Komal Dolasia, William Zhao, Peiwen Cai, Robert Sweeney, Elliot Merritt, Evgeny Kiner, Grace S Kim, Atharva Bhagwat, Thinh Nguyen, Samarth Hegde, Bailey G Fitzgerald, Sanjana Shroff, Travis Dawson, Monica Garcia-Barros, Jamshid Abdul-Ghafar, Rachel Chen, Sacha Gnjatic, Alan Soto 6, Rachel Brody, Seunghee Kim-Schulze, Zhihong Chen, Kristin G…

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Dual Malignancies Discovered: A Rare Case of Malignant Peritoneal Epithelioid Mesothelioma and Lung Adenocarcinoma

Cureus 2024 May 9 [Link] Mark A Potesta Jr, Emma Guld, Jennifer Laman Abstract Clinicians diagnosing malignant peritoneal epithelioid mesothelioma (MPM or MPeM) have historically had challenges due to the low incidence of the disease, as well as the often vague symptomatology that patients present with. Newer advances in technology, specifically in immunocytochemistry, have provided…

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Immediate Versus Deferred Systemic Therapy in Patients With Mesothelioma

Clinical Lung Cancer 2024 April 20 [Link] Sabine Schmid, Luna Zhan, Miguel Garcia, Kristen Dietrich, Khaleeq Khan, Maisha Chowdhury, Michael Herman, Devalben Patel, Fatemeh Zaeimi, Natasha B Leighl, Adrian Sacher, Ronald Feld, Frances A Shepherd, Laura Donahoe, Marc de Perrot, B C John Cho, Geoffrey Liu, Penelope A Bradbury Abstract Background: The 2018 ASCO pleural…

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FK228 suppress the growth of human malignant pleural mesothelioma tumor independent to epithelioid or non-epithelioid histology

Molecular Medicine 2024 May 31 [Link] James Mei-Lin Chan, Yuan-Ching Chang, Hua-Chen Chan, Hsiu-Chuan Chan, Wei-Chin Chang, Liu-Fang Wang, Tung-Hu Tsai, Yu-Jen Chen, Wen-Chien Huang Abstract Human malignant pleural mesothelioma (hMPM) is an aggressive, rare disease with a poor prognosis. Histologically, MPM is categorized into epithelioid, biphasic, and sarcomatoid subtypes, with the epithelioid subtype generally…

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