Real-world outcomes of multimodal treatment for pleural mesothelioma: A retrospective study in a high-volume integrated regional center

JTCVS Open 2026 January 30 [Link] Alison S Baskin, Keza Levine, Yun-Yi Hung, Elaine Liang, Kian C Banks, J Marie Suga, Jeffrey B Velotta Abstract Objective: To evaluate overall survival (OS) associated with multimodal treatment regimens, including pleurectomy/decortication (PD) and systemic therapy, in patients with clinical stage I-II epithelioid pleural mesothelioma (PM). Methods: We identified…

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Checkpoint kinase 1 protein as a diagnostic marker for pleural mesothelioma

Journal of the American society of Cytopathology 2026 March 28 [Link] Azadeh Asghari Birbaneh, Christos Meristoudis, Caspar Bundgaard Nielsen, Weronika Maria Szejniuk, Morten Johansen, Peter Derek Christian Leutscher, Vasiliki Panou, Oluf Dimitri Røe Abstract Introduction: Pleural mesothelioma (PM) is an aggressive malignancy that poses diagnostic challenges, particularly in cytological specimens. Checkpoint kinase 1 (CHK1); a…

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Gene expression and immunohistochemical phenotypes of high-grade epithelioid mesothelioma

Human Pathology 2026 July [Link] Marie-France Gagnon, Krasimira Rozenova, Chien Lu, Carlos Sosa, Beth Pitel, Matthew Petersen, Sydney Clausen, Anja C Roden, Kevin C Halling, Ying-Chun Lo Abstract Grading of epithelioid mesothelioma (EM) has recently been reported to be predictive of survival. We investigated whether RNA expression profiles and immunohistochemical (IHC) markers could refine EG…

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Update on pleural epithelioid mesothelioma: New insights for diagnosis and patient management

Journal of Thoracic Oncology 2026 April 8 [Link] Francoise Galateau Sallé, Mary Beth Beasley, Luka Brcic, Wendy Cooper 4, Sanja Dacic, Marc de Perrot, Ming-Sound Tsao, Sonja Klebe, Andrew Churg, Aaron S Mansfield, Paul Baas Abstract Diffuse Mesothelioma is typically diagnosed through histopathologic evaluation. Recent advances in therapeutic strategies have heightened the importance of accurate…

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MesoRet: a reticulin stain-based deep learning algorithm to assist diffuse mesothelioma subtyping

Pathologica 2026 February [Link] Giulia Orlando, Anna Paola Ferrero, Giorgia Andrea Impalà, Alessandra Pittaro, Luisa Delsedime, Rute Pedrosa, Darshan Kumar, Luisella Righi, Giuseppe Pelosi, Mauro Giulio Papotti, Eleonora Duregon Abstract Objective: To develop and validate a deep learning model trained on reticulin-stained whole slide images (MesoRet) to accurately identify transitional features and assist in the…

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A case of delayed recurrence of pleural mesothelioma with intradural invasion

Surgical Neurology International 2026 March 20 [Link] Hidetoshi Sato, Rui Omichi, Yuto Nigami, Nobuyuki Shimokawa Abstract Background: Pleural mesothelioma (PM) is a tumor of the pleural epithelium with a poor prognosis. Asbestos exposure is closely related to its occurrence. To date, there have been 13 reports of PM with intradural invasion. Case description: A 73-year-old male was…

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Clinical, diagnostic and prognostic relevance of GATA3 in malignant pleural mesothelioma: a retrospective cohort study

BMC Cancer 2026 April 2 [Link] Alejandro Avilés-Salas, David Dávila Dupont, Alejandro Aranda-Gutierrez, Andrea Nallely Heredia-Jara, Enrique Caballé-Perez, Luis Cabrera-Miranda, Andrés F Cardona, José Lucio-Lozada, Cesar Castillo-Ruiz, Norma Hernandez-Pedro, Luis Corrales, Claudio Martin, Oscar Arrieta Abstract Background: Malignant pleural mesothelioma (MPM) is an aggressive malignancy with a poor prognosis and limited treatment options. Recently, GATA3 has emerged as a useful adjunct immunohistochemical marker, especially for non-epithelioid subtypes. Although…

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Hormonal Status May Contribute to Sex-Based Survival Differences in Epithelioid Peritoneal Mesothelioma

Annals of Surgical Oncology 2026 March 12 [Link] Kaelyn C Cummins, Olivia Sears, Elio R Bitar, Chengli Shen, Allan Tsung, Samantha M Ruff Abstract Background: Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is central to treating patients with epithelioid peritoneal mesothelioma (EPM). Male sex is a negative prognostic factor in mesothelioma, but the reasons…

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