Epithelioid
CHIMERA: A Phase II Study of Neoadjuvant Pembrolizumab in Combination With Cisplatin or Carboplatin and Pemetrexed Followed by Surgery and Adjuvant Pembrolizumab in Resectable Pleural Mesothelioma
Clinical Lung Cancer 2026 July [Link] Giulia Pasello, Daniela Scattolin, Eleonora Faccioli, Paolo Andrea Zucali, Giuseppe Marulli, Federica Grosso, Giovanni Luca Ceresoli, Marcello Tiseo, Alessandra Bearz, Fabiana Letizia Cecere, Luana Calabrò, Francesco Callegarin, Paola Del Bianco, Gian Luca De Salvo, Federica Pezzuto, Fiorella Calabrese, Valentina Guarneri, Andrea Dell’Amore, Federico Rea Abstract Pleural mesothelioma (PM) is…
Read MoreKi67 proliferation index augments two-tier tumour grade in prediction of survival and progression-free survival in epithelioid pleural mesothelioma
ERJ Open Research 2026 June 8 [Link] Geraldine A Lynch, Yu Zhi Zhang, Nidhi Bhatt, Pia Charters, Avinash Aujayeb, Saru Walker, Jenny Symonds, Amelia O Clive, Rahul Bhatnagar, Anna Morley, Paul White, Andrew G Nicholson, Nick A Maskell, Anna Bibby Abstract Background: Pleural mesothelioma (PM) is a fatal asbestos-related cancer with a poor and often…
Read MoreIncreased Toll-like receptor 9 expression associated with cellular proliferation and poor prognosis in pleural mesothelioma
Journal of Pathology and Translational Medicine 2026 July [Link] Ali Omar Abdelaziz, Dina Moustafa Thabit, Rehab Mohamed Kamal, Hend Moness, Rasha Fouad Ahmed, Mariana Fathy Gayyed, Fatma El Zahraa Ammar Mohamed Abstract Background: Pleural mesothelioma is an aggressive malignancy with a poor prognosis. The epithelioid subtype is the most common and can be challenging to…
Read MoreClinical utility and prognostic value of GATA3 in epithelioid malignant mesothelioma: a practical and cost-effective approach for resource-limited settings
Journal of Clinical Pathology 2026 June 18 [Link] Dina Moustafa Thabit, Dalia M Thabet Abstract Aims: Distinguishing epithelioid malignant mesothelioma (EMM) from poorly differentiated lung adenocarcinoma (PD-LUAD) remains challenging, particularly when 21.7% of PD-LUADs lack lineage-specific markers (thyroid transcription factor-1 (TTF-1)/Napsin A), creating a diagnostic blind spot. While GATA-binding protein 3 (GATA3) is established in…
Read MoreDevelopment of Mesothelioma in Organ Transplant Recipients: A Comprehensive Study of 10 Cases
Archives of Pathology & Laboratory Medicine 2026 May 11 [Link] Huihua Li, Andre E Nel, Sergio Pina-Oviedo, John M Carney, Carolyn H Glass, Thomas A Sporn, Richard Attanoos, Aliya N Husain, Sonja Klebe, Beiyu Liu, Victor L Roggli, Elizabeth N Pavlisko Abstract Context.—: The development of malignancy after organ transplant has been well recognized as…
Read MoreReal-world outcomes of multimodal treatment for pleural mesothelioma: A retrospective study in a high-volume integrated regional center
JTCVS Open 2026 January 30 [Link] Alison S Baskin, Keza Levine, Yun-Yi Hung, Elaine Liang, Kian C Banks, J Marie Suga, Jeffrey B Velotta Abstract Objective: To evaluate overall survival (OS) associated with multimodal treatment regimens, including pleurectomy/decortication (PD) and systemic therapy, in patients with clinical stage I-II epithelioid pleural mesothelioma (PM). Methods: We identified…
Read MoreCheckpoint kinase 1 protein as a diagnostic marker for pleural mesothelioma
Journal of the American society of Cytopathology 2026 March 28 [Link] Azadeh Asghari Birbaneh, Christos Meristoudis, Caspar Bundgaard Nielsen, Weronika Maria Szejniuk, Morten Johansen, Peter Derek Christian Leutscher, Vasiliki Panou, Oluf Dimitri Røe Abstract Introduction: Pleural mesothelioma (PM) is an aggressive malignancy that poses diagnostic challenges, particularly in cytological specimens. Checkpoint kinase 1 (CHK1); a…
Read MoreGene expression and immunohistochemical phenotypes of high-grade epithelioid mesothelioma
Human Pathology 2026 July [Link] Marie-France Gagnon, Krasimira Rozenova, Chien Lu, Carlos Sosa, Beth Pitel, Matthew Petersen, Sydney Clausen, Anja C Roden, Kevin C Halling, Ying-Chun Lo Abstract Grading of epithelioid mesothelioma (EM) has recently been reported to be predictive of survival. We investigated whether RNA expression profiles and immunohistochemical (IHC) markers could refine EG…
Read MoreUpdate on pleural epithelioid mesothelioma: New insights for diagnosis and patient management
Journal of Thoracic Oncology 2026 April 8 [Link] Francoise Galateau Sallé, Mary Beth Beasley, Luka Brcic, Wendy Cooper 4, Sanja Dacic, Marc de Perrot, Ming-Sound Tsao, Sonja Klebe, Andrew Churg, Aaron S Mansfield, Paul Baas Abstract Diffuse Mesothelioma is typically diagnosed through histopathologic evaluation. Recent advances in therapeutic strategies have heightened the importance of accurate…
Read MoreMesoRet: a reticulin stain-based deep learning algorithm to assist diffuse mesothelioma subtyping
Pathologica 2026 February [Link] Giulia Orlando, Anna Paola Ferrero, Giorgia Andrea Impalà, Alessandra Pittaro, Luisa Delsedime, Rute Pedrosa, Darshan Kumar, Luisella Righi, Giuseppe Pelosi, Mauro Giulio Papotti, Eleonora Duregon Abstract Objective: To develop and validate a deep learning model trained on reticulin-stained whole slide images (MesoRet) to accurately identify transitional features and assist in the…
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