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Analysis of Pleiotropic Effects of Nivolumab in Patients with Relapsed Pleural Mesothelioma: A Single-Center Retrospective Study
Oncology 2025 January 24 [Link] Tomoki Higashiyama, Kozo Kuribayashi, Hiroshi Doi, Aki Kubota, Taiichiro Otsuki, Yasuhiro Nakajima, Koji Mikami, Ryo Takahashi, Akifumi Nakamura, Daichi Fujimoto, Kazuhiro Kitajima, Toshiyuki Minami, Takashi Kijima Abstract Introduction: In August 2018, the Japanese PMDA approved nivolumab, an immune checkpoint inhibitor, for previously treated, unresectable, advanced, or recurrent pleural mesothelioma (PM)…
Read MoreOvercoming resistance to arginine deprivation therapy using GC7 in pleural mesothelioma
iScience 2024 December 2 [Link] Josephine Carpentier, Marta Freitas, Valle Morales, Katiuscia Bianchi, John Bomalaski, Peter Szlosarek, Sarah A Martin Abstract Pleural mesothelioma is a highly chemotherapy-resistant cancer. Approximately 50% of mesotheliomas do not express argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme in arginine biosynthesis, making arginine depletion with pegylated arginine deiminase (ADI-PEG20) an attractive…
Read MoreDiagnostic Differentiation Between Two Rare Entities-Metastatic Peritoneal Mesothelioma With Duodenal Involvement and Duodenal Synovial Sarcoma: A Case Report
Cureus 2024 November 29 [Link] Bruna Haueisen Figueiredo Zwetkoff, Fauze Maluf-Filho, Filadélfio E Venco, Roberto Blasbalg, Evandro Sobroza de Mello, Mauricio Fernando de Almeida Barros Abstract This case report highlights the diagnostic challenges in distinguishing between metastatic peritoneal mesothelioma with duodenal involvement and synovial sarcoma of the duodenum, two rare and complex entities. A 59-year-old…
Read MoreAnalysis of TERT mRNA Levels and Clinicopathological Features in Patients with Peritoneal Mesothelioma
Cancers 2025 January 14 [Link] Antonio d’Amati, Gabriella Serio, Andrea Quaranta, Luigi Vimercati, Michelina De Giorgis, Loredana Lorusso, Mariella Errede, Vito Longo, Andrea Marzullo, Domenico Ribatti, Tiziana Annese Abstract Background/objectives: Telomerase reverse transcriptase (TERT) is the catalytic subunit of the telomerase enzyme responsible for telomere length maintenance and is an important cancer hallmark. Our study…
Read MoreThe Effect of Systemic Inflammation and Clinicopathologic Features on Survival in Malignant Pleural Mesothelioma: A Multicenter Analysis
Medicina 2025 January 16 [Link] Nadiye Sever, Sedat Yıldırım, Ali Fuat Gurbuz, Delyadil Karakaş Kılıç, Esra Zeynelgil, Yunus Emre Altintaş, Berivan Deniz Çimik, Yeşim Ağyol, Ali Kaan Güren, Pınar Erel, Erkam Kocaaslan, Burak Paçacı, Mustafa Alperen Tunç, Abdussamet Çelebi, Nazım Can Demircan, Selver Işık, Rukiye Arıkan, Murat Araz, Serdar Karakaya, Murat Sarı, Osman Köstek, İbrahim…
Read MoreSurgical indications for pleurectomy/decortication in pleural mesothelioma based on the newly revised 9th edition of the tumour-node-metastasis classification
Interdisciplinary Cardiovascular and Thoracic Surgery 2024 December 25 [Link] Masatoshi Kanayama, Masaru Takenaka, Takehiko Manabe, Katsuma Yoshimatsu, Rintaro Oyama, Hiroki Matsumiya, Masataka Mori, Koji Kuroda, Fumihiro Tanaka Abstract Objectives: The MARS2 trial questioned the efficacy of curative intent surgery for pleural mesothelioma (PM), while real-world clinical data from Japan suggest a favourable prognosis in surgical…
Read MoreCase report: Radiological features of a case of desmoplastic malignant mesothelioma of peritoneum
Frontiers in Oncology 2024 December 11 [Link] Jingchao Wang, Heping Deng Abstract Desmoplastic malignant peritoneal mesothelioma (DMPM) is an extremely rare and aggressive subtype of sarcomatoid malignant mesothelioma, originating from the mesothelial lining of body cavities. It is characterized by significant local invasiveness and poor prognosis. The nonspecific symptoms of DMPM often result in delayed…
Read MoreEcteinascidin synthetic analogues: a new class of selective inhibitors of transcription, exerting immunogenic cell death in refractory malignant pleural mesothelioma
Journal of Experimental & Clinical Cancer Research 2024 December 21 [Link] I C Salaroglio, P Aviles, J Kopecka, A Merlini, F Napoli, L Righi, S Novello, H Sullivan, C Cuevas, G V Scagliotti, C Riganti Abstract Background: Malignant pleural mesothelioma (MPM) is a highly chemo-refractory and immune-evasive tumor that presents a median overall survival of…
Read MoreAmerican Association of Bronchology and Interventional Pulmonology Essential Knowledge in Interventional Pulmonology Series: Selected Topics in Malignant Pleural Disease
Journal of Bronchology and Interventional Pulmonology 2024 December 20 [Link] Ara A Chrissian, Hatoon Abbas, Udit Chaddha, Labib G Debiane, Erin DeBiasi, Darius Filsoof, Muhammad Daniyal Hashmi, Christopher Morton, Warren C Naselsky, Jasleen Pannu, Reza Ronaghi, Bertin D Salguero, Cristina Salmon, Shelby J Stewart, Colleen L Channick Abstract The goal of the American Association of…
Read MoreHuman Exposure to Asbestos in Central Asian Countries and Health Effects: A Narrative Review
La Medicina del lavoro 2024 December 19 [Link] Zhyldyz Kurzhunbaeva, Kenesh Dzhusupov, Andrea Spinazzè, Silvia Damiana Visonà, Cholpon Sulaimanova, Omor Kasymov, Elena Belluso, Claudio Colosio Abstract The discovery of the detrimental effects of asbestos on human health came long after its widespread use, with the first scientific evidence of asbestos-related diseases emerging in the late…
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