Comprehensive genomic profiling of pediatric peritoneal mesothelioma: case report with a literature review

Journal of Surgical Case Reports 2024 May 18 [Link] Jasmina Redzepagic, Zlatan Zvizdic, Nurija Bilalovic, Emir Milisic, Melika Bukvic, Semir Vranic Abstract Malignant peritoneal mesothelioma is an extremely rare and poorly recognized neoplasm in children. A 5-year-old boy presented with a 1-year history of progressive painless abdominal distension. A CT revealed a 19 Ă— 19…

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A systematic review of minimally invasive cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with peritoneal malignancy

ANZ Journal of Surgery 2024 May 15 [Link] Lauren Cohen, Faizah Alam, Michael P Flood, Helen Mohan, Anshini Jain, Glen Guerra, Alexander G Heriot, Joseph C H Kong Abstract Background: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is traditionally a maximally invasive operation with a large abdominal incision and multi-visceral resections. However, to minimize…

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Differential expression of DMD transcripts as a novel prognostic biomarker in histologically diverse mesotheliomas

Translational Lung Cancer Research 2024 April 29 [Link] Nancy Alnassar, Jonathan M J Derry, Giuseppe Luigi Banna, Dariusz C Gorecki Abstract Background: The identification of prognostic biomarkers is crucial for guiding treatment strategies in mesothelioma patients. The Duchenne muscular dystrophy (DMD) gene and its specific transcripts have been associated with patient survival in various tumours.…

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Extended pleurectomy decortication and chemotherapy versus chemotherapy alone for pleural mesothelioma (MARS 2): a phase 3 randomised controlled trial

The Lancet Respiratory Medicine 2024 May 10 [Link] Eric Lim, David Waller, Kelvin Lau, Jeremy Steele, Anthony Pope, Clinton Ali, Rocco Bilancia, Manjusha Keni, Sanjay Popat, Mary O’Brien, Nadza Tokaca, Nick Maskell, Louise Stadon, Dean Fennell, Louise Nelson, John Edwards, Sara Tenconi, Laura Socci, Robert C Rintoul, Kelly Wood, Amanda Stone, Dakshinamoorthy Muthukumar, Charlotte Ingle,…

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Leveraging the pleural space for anticancer therapies in pleural mesothelioma

The Lancet Respiratory Medicine 2024 May 10 [Link] Kevin G Blyth, Prasad S Adusumilli, Philippe Astoul, Liz Darlison, Y C Gary Lee, Aaron S Mansfield, Stefan J Marciniak, Nick Maskell, Vasiliki Panou, Tobias Peikert, Najib M Rahman, Marjorie G Zauderer, Daniel Sterman, Dean A Fennell Abstract Most patients with pleural mesothelioma (PM) present with symptomatic…

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Differential expression of DMD transcripts as a novel prognostic biomarker in histologically diverse mesotheliomas

Translational Lung Cancer Research 2024 April 29 [Link] Nancy Alnassar, Jonathan M J Derry, Giuseppe Luigi Banna, Dariusz C Gorecki Abstract Background: The identification of prognostic biomarkers is crucial for guiding treatment strategies in mesothelioma patients. The Duchenne muscular dystrophy (DMD) gene and its specific transcripts have been associated with patient survival in various tumours.…

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Diagnostic Accuracy of Ultrasound Guided Percutaneous Pleural Needle Biopsy for Malignant Pleural Mesothelioma

Journal of Clinical Medicine 2024 April 29 [Link] Carlo Iadevaia, Vito D’Agnano, Raffaella Pagliaro, Felice Nappi, Raffaella Lucci, Simona Massa, Andrea Bianco, Fabio Perrotta Abstract Background/Objectives: Ultrasound (US) has been progressively spreading as the most useful technique for guiding biopsies and fine-needle aspirations that are performed percutaneously. Malignant pleural mesothelioma (MPM) represents the most common…

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Malignant peritoneal mesothelioma presenting with bilateral hydronephrosis and renal insufficiency: a case report and literature review

Frontiers in Surgery 2024 April 24 [Link] Jisheng Luo, Jinhong Pan, Chuanhua Zhong, Lina Wang, Heng Zhang Abstract Introduction: Malignant peritoneal mesothelioma (MPM) is an extremely rare tumor with nonspecific clinical manifestations, making diagnosis challenging. Case presentation: Herein, we report a case of MPM with occult onset presenting with bilateral hydronephrosis and renal insufficiency. A…

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BAP1 Deficiency Inflames the Tumor Immune Microenvironment and Is a Candidate Biomarker for Immunotherapy Response in Malignant Pleural Mesothelioma

JTO Clinical and Research Reports 2024 March 29 [Link] Duo Xu, Yanyun Gao, Haitang Yang, Marc Spils, Thomas M Marti, Tereza Losmanová, Min Su, Wenxiang Wang, Qinghua Zhou, Patrick Dorn, Yongqian Shu, Ren-Wang Peng Abstract Introduction: Malignant pleural mesothelioma (MPM) is a rare and universally lethal malignancy with limited treatment options. Immunotherapy with immune checkpoint…

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