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Immune Checkpoint Inhibitor Uptake in Real-World Patients With Malignant Pleural Mesothelioma
JTO Clinical and Research Reports 2021 May 18 [Link] Roger Y Kim, Nandita Mitra, Stephen J Bagley, Melina E Marmarelis, Andrew R Haas, Katharine A Rendle, Anil Vachani Abstract Introduction: Since the July 2017 National Comprehensive Cancer Network (NCCN) malignant pleural mesothelioma (MPM) guideline revision recommended second-line immune checkpoint inhibitors (ICIs), studies have suggested a…
Read MoreInhibition of CDK4/6 Overcomes Primary Resistance to PD-1 Blockade in Malignant Mesothelioma
The Annals of Thoracic Surgery 2021 September 27 [Link] Hee-Jin Jang, Cynthia Y Truong, Eric M Lo, Hudson M Holmes, Daniela Ramos, Maheshwari Ramineni, Ju-Seog Lee, Daniel Y Wang, Massimo Pietropaolo, R Taylor Ripley, Bryan M Burt, Hyun-Sung Lee Abstract Background: Despite the profound number of malignant pleural mesothelioma (MPM) patients now treated with PD-1…
Read MoreMatrix Metalloproteinases as Biomarkers and Treatment Targets in Mesothelioma: A Systematic Review
Biomolecules 2021 August 25 [Link] Danijela Štrbac, Vita Dolžan Abstract Metalloproteinases (MMPs) have an important role in tissue remodeling and have been shown to have an effect on tumor progression, invasion, metastasis formation, and apoptosis in several tumors, including mesothelioma. Mesothelioma is a rare tumor arising from pleura and peritoneum and is frequently associated with…
Read MoreHyperthermic Intrathoracic Chemotherapy (HITOC) after Cytoreductive Surgery for Pleural Malignancies-A Retrospective, Multicentre Study
Cancers 2021 September 12 [Link] Michael Ried, Julia Kovács, Till Markowiak, Karolina Müller, Gunnar Huppertz, Michael Koller, Hauke Winter, Laura V Klotz, Rudolf Hatz, Julia Zimmermann, Bernward Passlick, Severin Schmid, Mohamed Hassan, Martin E Eichhorn, Hans-Stefan Hofmann Abstract In the context of quality assurance, the objectives were to describe the surgical treatment and postoperative morbidity…
Read MoreIntegrated genomics point to immune vulnerabilities in pleural mesothelioma
Scientific Reports 2021 September 27 [Link] Anca Nastase , Amit Mandal, Shir Kiong Lu, Hima Anbunathan, Deborah Morris-Rosendahl, Yu Zhi Zhang, Xiao-Ming Sun Spyridon Gennatas, Robert C Rintoul, Matthew Edwards, Alex Bowman, Tatyana Chernova, Tim Benepal, Eric Lim, Anthony Newman Taylor, Andrew G Nicholson, Sanjay Popat, Anne E Willis, Marion MacFarlane, Mark Lathrop, Anne M…
Read MoreHyperthermic Intrathoracic Chemotherapy (HITOC) after Cytoreductive Surgery for Pleural Malignancies-A Retrospective, Multicentre Study
Cancers 2021 September 12 [Link] Michael Ried, Julia Kovács, Till Markowiak, Karolina Müller, Gunnar Huppertz, Michael Koller, Hauke Winter, Laura V Klotz, Rudolf Hatz, Julia Zimmermann, Bernward Passlick, Severin Schmid, Mohamed Hassan, Martin E Eichhorn, Hans-Stefan Hofmann Abstract In the context of quality assurance, the objectives were to describe the surgical treatment and postoperative morbidity…
Read MoreIntegrated genomics point to immune vulnerabilities in pleural mesothelioma
Scientific Reports 2021 September 27 [Link] Anca Nastase, Amit Mandal, Shir Kiong Lu, Hima Anbunathan, Deborah Morris-Rosendahl, Yu Zhi Zhang, Xiao-Ming Sun, Spyridon Gennatas, Robert C Rintoul, Matthew Edwards, Alex Bowman, Tatyana Chernova, Tim Benepal, Eric Lim, Anthony Newman Taylor, Andrew G Nicholson, Sanjay Popat, Anne E Willis, Marion MacFarlane, Mark Lathrop, Anne M Bowcock,…
Read MoreSurface-fill hydrogel attenuates the oncogenic signature of complex anatomical surface cancer in a single application
Nature Nanotechnology 2021 September 23 [Link] Poulami Majumder, Anand Singh, Ziqiu Wang, Kingshuk Dutta, Roma Pahwa, Chen Liang, Caroline Andrews, Nimit L Patel, Junfeng Shi, Natalia de Val, Scott T R Walsh, Albert Byungyun Jeon, Baktiar Karim, Chuong D Hoang, Joel P Schneider Abstract Tumours growing in a sheet-like manner on the surface of organs…
Read MoreMolecular characterization of pleomorphic mesothelioma: a multi-institutional study
Modern Pathology 2021 September 16 [Link] Somak Roy, Françoise Galateau-Sallé, Nolwenn Le Stang, Andrew Churg, Maureen A Lyons, Richard Attanoos, Sanja Dacic Abstract The molecular alterations of pleomorphic mesotheliomas are largely unknown. In the present study, we performed whole-exome sequencing (WES) on 24 pleomorphic mesotheliomas in order to better characterize the molecular profile of this…
Read MoreInvestigating the Efficacy of Zingerone on Mesothelioma and the Role of TRPV1 in This Effect
Nutrition and Cancer 2021 September 17 [Link] Sabahattin Cömertpay, Abdülmecit Gül, Mehmet Delibaş, Mehmet Semih Tekin Turhan Abstract Mesothelioma is a highly lethal cancer developing in the lung, heart, and abdominal membranes. Zingerone, a capsaicin-like bioactive compound, has been shown to have anticancer properties. Transient Receptor Potential Vanilloid 1 (TRPV1) is an ion channel involving…
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