Sarcomatoid
Regional immunosuppression and associated systemic markers in focally relapsed sarcomatoid mesothelioma: case report
Journal for Immunotherapy of Cancer 2026 April 15 [Link] Hely Ollila, Prateek Kulkarni, Hyojin Kim, Pratiti Ankola, Navin K Chintala, Carlos Thomas, Jennifer L Sauter, Michael Offin, Prasad S Adusumilli Abstract A 52-year-old man presented with sarcomatoid diffuse pleural mesothelioma that had relapsed at an isolated site after a complete response to dual-immune checkpoint inhibition…
Read MoreGene expression and immunohistochemical phenotypes of high-grade epithelioid mesothelioma
Human Pathology 2026 July [Link] Marie-France Gagnon, Krasimira Rozenova, Chien Lu, Carlos Sosa, Beth Pitel, Matthew Petersen, Sydney Clausen, Anja C Roden, Kevin C Halling, Ying-Chun Lo Abstract Grading of epithelioid mesothelioma (EM) has recently been reported to be predictive of survival. We investigated whether RNA expression profiles and immunohistochemical (IHC) markers could refine EG…
Read MoreUpdate on pleural epithelioid mesothelioma: New insights for diagnosis and patient management
Journal of Thoracic Oncology 2026 April 8 [Link] Francoise Galateau Sallé, Mary Beth Beasley, Luka Brcic, Wendy Cooper 4, Sanja Dacic, Marc de Perrot, Ming-Sound Tsao, Sonja Klebe, Andrew Churg, Aaron S Mansfield, Paul Baas Abstract Diffuse Mesothelioma is typically diagnosed through histopathologic evaluation. Recent advances in therapeutic strategies have heightened the importance of accurate…
Read MoreMesoRet: a reticulin stain-based deep learning algorithm to assist diffuse mesothelioma subtyping
Pathologica 2026 February [Link] Giulia Orlando, Anna Paola Ferrero, Giorgia Andrea Impalà, Alessandra Pittaro, Luisa Delsedime, Rute Pedrosa, Darshan Kumar, Luisella Righi, Giuseppe Pelosi, Mauro Giulio Papotti, Eleonora Duregon Abstract Objective: To develop and validate a deep learning model trained on reticulin-stained whole slide images (MesoRet) to accurately identify transitional features and assist in the…
Read MoreBrain Metastases in Diffuse Pleural Mesothelioma: Clinical, Histologic, and Molecular Correlates
JTO Clinical and Research Reports 2026 February 5 [Link] Antonio Ocejo, Clare Wilhem, Francis M Bodd, Andrea Arfe, Marjorie G Zauderer, Afsheen Iqbal, Juliana Eng, Yao Yu, Joshua A Budhu, Javin Schefflein, Robert Young, Mark G Kris, Nelson S Moss, Rabih Bou-Nassif, Charles B Simone 2nd, Prasad S Adusumilli, Jennifer L Sauter, Michael Offin Abstract…
Read MoreCase Report: Immune checkpoint inhibitor-triggered anti-Ma2 paraneoplastic encephalitis in sarcomatoid pleural mesothelioma: a fatal case
Frontiers in Oncology 2026 March 9 [Link] Ilker Nihat Okten, Tuba Baydaş Abstract Background: Neurological immune-related adverse events (N-irAEs) represent rare but potentially fatal complications of immune checkpoint inhibitor (ICI) therapy. Among these, encephalitis associated with paraneoplatic neuronal antibodies poses a major diagnostic and therapeutic challenge, as it blurs the distinction between drug-induced toxicity and…
Read MorePleural Fluid Cytology-Histology Correlation in Patients With Malignant Pleural Mesothelioma: A Series of 26 Cases
Cytopathology 2026 February 20 [Link] John Findley, Matthew Demetrious, Lucas Yan, Lei Yan Abstract Background: To understand the efficacy of pleural effusion cytology in the diagnosis of malignant mesothelioma, we conducted this retrospective study to review the pleural fluid cytologies of patients diagnosed on concurrent/recent pleural biopsy histology. The clinicopathologic features and common cytomorphology were…
Read MoreBAP-1 in the diagnosis of malignant pleural mesothelioma
Respiratory Medicine and Research 2025 November 28 [Link] Irene Sansano, Ana Vázquez, Oscar Persiva, Marc Simó, Leire Sánchez, Pilar Montoya, Carme Dinarès, Carmen Alemán Abstract Background: The diagnosis of malignant pleural mesothelioma (MPM) can be challenging for clinicians and pathologists. Patients and methods: This study included all patients diagnosed with pleural mesothelioma between October 2013…
Read MoreFeasibility of multimodality treatment, including pleurectomy decortication, in carefully selected patients with sarcomatoid mesothelioma
Translational Lung Cancer Research 202t6 January 31 [Link] Moshe Lapidot, Emanuele Mazzola, Raphael Bueno Abstract Background: Pleural mesothelioma (PM) represents an uncommon and exceptionally lethal malignancy. The sarcomatoid subtype constitutes the rarest histological variant, traditionally linked to the worst prognosis, while the advantages of operative intervention remain inadequately established. In this study, we present findings…
Read MoreConstruction and validation of a prognostic risk score model for malignant mesothelioma
Discover Oncology 2026 February 8 [Link] Qingzheng An, Fengyun Cui, Guangming Shi, Longkun Ni, Kun Xiao, Feng Tian, Yuezhi Chen, Leping Li, Changqing Jing, Guodong Lian Abstract Purpose: Malignant mesothelioma is a rare, aggressive cancer. Although the World Health Organization (WHO) histologic subtypes–epithelioid (best prognosis), biphasic, and sarcomatoid (worst prognosis)—provide baseline stratification, architectural and molecular…
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