Vinorelbine
BAMLET kills chemotherapy-resistant mesothelioma cells, holding oleic acid in an activated cytotoxic state.
PloS One 2018 August 29 [Link] Rath EM, Cheng YY, Pinese M, Sarun KH, Hudson AL, Weir C, Wang YD, Håkansson AP, Howell VM, Liu GJ, Reid G, Knott RB, Duff Abstract Malignant pleural mesothelioma is an aggressive cancer with poor prognosis. Here we have investigated in vitro efficacy of BAMLET and BLAGLET complexes (anti-cancer…
Read MoreHigh RRM1 Expression Is Associated with Adverse Outcome in Patients with Cisplatin/Vinorelbine-treated Malignant Pleural Mesothelioma
Anticancer Research 2015 December [Link] Zimling ZG, Santoni-Rugiu E, Bech C, Sørensen JB. Abstract Background/Aim A possible predictive impact of ribonucleotide-reductase subunit-1 (RRM1) on vinorelbine efficacy in non-small cell lung cancer (NSCLC) has been previously reported. The present study aimed to further explore this finding in malignant pleural mesothelioma (MPM). Materials and Methods Seventy-one patients…
Read MoreSystemic Treatments for Mesothelioma: Standard and Novel
Current Treatment Options in Oncology. 2008 Jun;9(2-3):171-9. Epub 2008 Sep 3. [Link] Kindler HL. Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA. hkindler@medicine.bsd.uchicago.edu Abstract Systemic therapy is the only treatment option for the majority of mesothelioma patients, for whom age, co-morbid medical illnesses, non-epithelial histology, and locally advanced disease often preclude surgery. For…
Read MoreCisplatin and vinorelbine first-line chemotherapy in non-resectable malignant pleural mesothelioma
British Journal of Cancer. 2008 Jun 10. [Epub ahead of print] [Link] Sørensen JB, Frank H, Palshof T. 1Department Oncology, Finsen Centre/National University Hospital, 9 Blegdamsvej, Copenhagen DK-2100, Denmark. Abstract The aim was to evaluate the activity of cisplatin and vinorelbine in previously untreated, inoperable patients having histologically verified malignant pleural mesothelioma (MPM), normal organ…
Read MoreResponse of a Patient with Pleural and Peritoneal Mesothelioma after Second-Line Chemotherapy with Lipoplatin and Gemcitabine
Oncology. 2007;73:426-429. [Link] Karpathiou G, Argiana E, Koutsopoulos A, Froudarakis ME. Department of Pneumonology, Medical School Democritus University of Thrace, Alexandroupolis, Greece. Abstract We report the case of a 56-year-old patient with malignant pleural mesothelioma of epithelial type, who responded to second-line chemotherapy with lipoplatin plus gemcitabine. Diagnosis and staging of the disease was done…
Read MoreThe efficacy and safety of weekly vinorelbine in relapsed malignant pleural mesothelioma
Lung Cancer. 2008 May 15. [Epub ahead of print] [Link] Stebbing J, Powles T, McPherson K, Shamash J, Wells P, Sheaff MT, Slater S, Rudd RM, Fennell D, Steele JP. Department of Medical Oncology, St. Bartholomew’s Hospital, West Smithfield, London EC1A 7BE, UK. Abstract Malignant pleural mesothelioma (MPM) is a rapidly progressive invariably lethal tumor.…
Read MoreActive symptom control with or without chemotherapy in the treatment of patients with malignant pleural mesothelioma (MS01): a multicentre randomised trial
Lancet. 2008 May 17;371(9625):1685-1694. [Link] Muers MF, Stephens RJ, Fisher P, Darlison L, Higgs CM, Lowry E, Nicholson AG, O’Brien M, Peake M, Rudd R, Snee M, Steele J, Girling DJ, Nankivell M, Pugh C, Parmar MK; on behalf of the MS01 Trial Management Group. Leeds General Infirmary, Leeds, UK. Abstract Background: Malignant pleural mesothelioma…
Read MoreGemcitabine and vinorelbine in pemetrexed-pretreated patients with malignant pleural mesothelioma
Cancer. 2008 Feb 19 [Epub ahead of print] [Link] Zucali PA, Ceresoli GL, Garassino I, De Vincenzo F, Cavina R, Campagnoli E, Cappuzzo F, Salamina S, Soto Parra HJ, Santoro A. Department of Medical Oncology and Hematology, Humanitas Clinical Institute of Rozzano, Milan, Italy. Abstract Background: Pemetrexed-cisplatin chemotherapy is the standard of care in the…
Read MoreCost-effectiveness of pemetrexed plus cisplatin: malignant pleural mesothelioma treatment in UK clinical practice
Value in Health. 2008 Jan-Feb;11(1):4-12. [Link] Cordony A, Le Reun C, Smala A, Symanowski JT, Watkins J. M-TAG Pty Ltd, A Unit of IMS Health, St Leonards, NSW, Australia. acordony@au.imshealth.com Abstract Objectives: Findings from the largest randomized phase III trial in patients with unresectable malignant pleural mesothelioma (EMPHACIS study; n = 448) were used to…
Read MoreA case of malignant mesothelioma presenting with recurrent pneumothorax
Nihon Kokyuki Gakkai Zasshi. 2006 Nov;44(11):807-11. [Link] Katayam N, Tokuda A, Nakatsumi Y, Oribe Y, Fujimura M. Department of Respiratory Medicine, Kanazawa Municipal Hospital. Abstract A 71-year-old man was found to have right hydropneumothorax by chest X-ray film on a regular checkup. Thoracic drainage and bullectomy by thoracoscopy did not improve the pneumothorax, so pleurodesis…
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