Biphasic or Mixed
Malignant Pleural Mesothelioma (MPM) Presenting as Hydropneumothorax
Cureus 2023 July 1 [Link] Masami Kuramochi, Takuma Muraoka, Mayumi Shinonaga, Haruo Ohtani, Setsuo Kuraoka Abstract An 86-year-old man presented with bilateral lower limb edema and was found to have hydropneumothorax on chest radiography. CT revealed a substantial pleural effusion and plaques. The patient had a history of working in a stone workshop, but the…
Read MoreGenetic Pathways in Peritoneal Mesothelioma Tumorigenesis
Cancer Genomics and Proteomics 2023 Jul-Aug [Link] Ioannis Panagopoulos, Kristin Andersen, Marta Brunetti, Ludmila Gorunova, Ben Davidson, Marius Lund-Iversen, Francesca Micci, Sverre Heim Abstract Background/aim: Mesotheliomas are tumors similar to, and probably derived from, mesothelial cells. They carry acquired chromosomal rearrangements, deletions affecting CDKN2A, pathogenetic polymorphisms in NF2, and fusion genes which often contain the…
Read MoreComparison of immunohistochemical mesothelial biomarkers in paired biopsies and effusion cytology cell blocks from pleural mesothelioma
Cytopathology 2023 June 19 [Link] Mohammed S I Mansour, Adela Huseinzade, Tomas Seidal, Kim Hejny, Athar Maty, Fereshteh Taheri-Eilagh, Ulrich Mager, Annika Dejmek, Katalin Dobra, Hans Brunnström Abstract Objective: Traditionally, the diagnosis of pleural mesothelioma is based on histological material. Minimally invasive effusion cytology specimens are an alternative that, like biopsies, require ancillary analyses. Validation…
Read MoreSequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts
Heliyon 2023 April 11 [Link] Zhenghua Zhang, Shasha Shen, Jiyao Ma, Tianfu Qi, Chao Gao, Xiong Hu, Dan Han, Yilong Huang Abstract Objective: It is still a challenge to find a noninvasive technique to distinguish the histological subtypes of malignant pleural mesothelioma (MPM) and characterize the development of related histological features. We investigated the potential…
Read MoreKRAS Mutations Are Associated with Shortened Survival in Patients with Epithelioid Malignant Pleural Mesothelioma
Cancers 2023 March 30 [Link] Margherita Vannucchi, Veronica Pennati, Clelia Mencaroni, Chiara Defraia, Ledi Bardhi, Francesca Castiglione, Cristiana Bellan, Camilla Eva Comin Abstract Malignant pleural mesothelioma (MPM) is an aggressive malignancy of the pleural surface that includes three major histologic subtypes, epitheliod, sarcomatoid and biphasic. Epithelioid mesothelioma is usually associated with better prognosis. The genetic…
Read MoreDisparities in Survival Due to Social Determinants of Health and Access to Treatment in US Patients With Operable Malignant Pleural Mesothelioma
JAMA Network Open 2023 March 1 [Link] Ahmed Alnajar, Samuel A Kareff, Syed S Razi, J Sunil Rao, Gilberto De Lima Lopes, Dao M Nguyen, Nestor Villamizar, Estelamari Rodriguez Abstract Importance: Outcomes of localized malignant pleural mesothelioma (MPM) remain poor despite multimodality therapy. It is unclear what role disparities have in the overall survival (OS)…
Read MoreEffects of pharmacological primary cilium disturbance in the context of in vitro 2D and 3D malignant pleura mesothelioma
Biochemical and Biophysical Research Communications 2023 April 30 [Link] Rajesh M Jagirdar, Eleanna Pitaraki, Ourania S Kotsiou, Erasmia Rouka, Sotirios I Sinis, Charalampos Varsamas, Periklis Marnas, Elpiniki Stergiopoulou, Anastasios Giannou, Chrissi Hatzoglou, Konstantinos I Gourgoulianis, Sotirios G Zarogiannis Abstract Introduction: Primary cilium (PC) is a single non-motile antenna-like organelle composed of a microtubule core axon…
Read MorePrognostic Value of EMT Gene Signature in Malignant Mesothelioma
International Journal of Molecular Sciences 2023 February 21 [Link] Licun Wu, Kosuke Yoshihara, Hana Yun, Saraf Karim, Nastaran Shokri, Fatemeh Zaeimi, H S Jeffrey Man, Amin Zia, Emanuela Felley-Bosco, Marc de Perrot Abstract Malignant mesothelioma (MESO) consists of epithelioid, biphasic, and sarcomatoid subtypes with different epithelial-mesenchymal transition (EMT) phenotypes. We previously identified a panel of…
Read MoreDiverse and divergent functions of IL-32β and IL-32γ isoforms in the regulation of malignant pleural mesothelioma cell growth and the production of VEGF-A and CXCL8
Cell Immunology 2023 January [Link] Muneo Numasaki, Koyu Ito, Kiyoshi Takagi, Kengo Nagashima, Hirotsugu Notsuda, Hirokazu Ogino, Rika Ando, Yoshihisa Tomioka, Takashi Suzuki, Yoshinori Okada, Yasuhiko Nishioka, Michiaki Unno Abstract In this study, we sought to elucidate the roles of the interleukin (IL)-32β and IL-32γ in mesothelioma cell growth, and vascular endothelial growth factor (VEGF)-A…
Read MoreMalignant Peritoneal Mesothelioma Features Shown by FDG-PET/CT
Cancer Diagnosis & Prognosis 2022 November 3 [Link] Kozo Kuribayashi, Kazuhiro Kitajima, Toshiyuki Minami, Masataka Ikeda, Koichiro Yamakado, Takashi Kijima Abstract Background/aim: Malignant peritoneal meso-thelioma (MPeM) has no specific imaging findings that can distinguish it from other peritoneal tumors and the accuracy of peritoneal cytology is low, therefore definitive diagnosis is usually performed by histology.…
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