Immunohistochemistry or IHC
Cancer-Associated Fibroblasts Influence Survival in Pleural Mesothelioma: Digital Gene Expression Analysis and Supervised Machine Learning Model
International Journal of Molecular Science 2023 August 4 [Link] Sabrina Borchert, Alexander Mathilakathu, Alina Nath, Michael Wessolly, Elena Mairinger, Daniel Kreidt, Julia Steinborn, Robert F H Walter, Daniel C Christoph, Jens Kollmeier, Jeremias Wohlschlaeger, Thomas Mairinger, Luka Brcic, Fabian D Mairinger Abstract The exact mechanism of desmoplastic stromal reaction (DSR) formation is still unclear. The…
Read MoreExpression of TILs and Patterns of Gene Expression from Paired Samples of Malignant Pleural Mesothelioma (MPM) Patients
Cancers 2023 July 14 [Link] Susana Cedres, Garazi Serna, Alberto Gonzalez-Medina, Augusto Valdivia, Juan David Assaf-Pastrana, Patricia Iranzo, Ana Callejo, Nuria Pardo, Alejandro Navarro, Alex Martinez-Marti, Ilaria Priano, Roberta Fasani, Xavier Guardia, Javier Gonzalo, Caterina Carbonell, Joan Frigola, Ramon Amat, Victor Navarro, Rodrigo Dienstmann, Ana Vivancos, Paolo Nuciforo, Enriqueta Felip Abstract MPM is an aggressive…
Read MoreExpression of stathmin in asbestos-like fibers-induced mesothelioma: A preliminary report
Histology and Histopathology 2023 June 30 [Link] Claudia Lombardo, Giuseppe Broggi, Ermanno Vitale, Caterina Ledda, Carla Loreto, Serena Matera, Maria Hagnas, Rosario Caltabiano, Veronica Filetti Abstract Background: Mesothelioma is strongly associated with exposure to asbestos fibers, however, recent studies have also linked exposure to “naturally occurring asbestos” fibers with this disease. Fluoro-edenite, a silicate mineral…
Read MoreAsbestos accelerates disease onset in a genetic model of malignant pleural mesothelioma
Frontiers in Toxicology 2023 June 27 [Link] Pooyeh Farahmand, Katarina Gyuraszova, Claire Rooney, Ximena L Raffo-Iraolagoitia, Geeshath Jayasekera, Ann Hedley, Emma Johnson, Tatyana Chernova, Gaurav Malviya, Holly Hall, Tiziana Monteverde, Kevin Blyth, Rodger Duffin, Leo M Carlin, David Lewis, John Le Quesne, Marion MacFarlane, Daniel J Murphy Abstract Hypothesis: Asbestos-driven inflammation contributes to malignant pleural…
Read MoreVEGFR2 and CD34 expression associated with longer survival in patients with pleural mesothelioma in the IFCT-GFPC-0701 MAPS phase 3 trial
Lung Cancer 2023 August [Link] Guénaëlle Levallet, Fatéméh Dubois, Nicolas Elie, Christian Creveuil, Solenn Brosseau, Claire Danel, Arnaud Scherpereel, Sylvie Lantuejoul, Julien Mazières, Laurent Greillier, Clarisse Audigier-Valette, Emmanuel Bergot, Denis Moro-Sibilot, Olivier Molinier, Hervé Léna, Isabelle Monnet, Franck Morin, Valérie Gounant, Gérard Zalcman Abstract Objectives: VEGF/VEGFR autocrine loop is a hallmark of pleural mesothelioma (PM).…
Read MoreComparison of immunohistochemical mesothelial biomarkers in paired biopsies and effusion cytology cell blocks from pleural mesothelioma
Cytopathology 2023 June 19 [Link] Mohammed S I Mansour, Adela Huseinzade, Tomas Seidal, Kim Hejny, Athar Maty, Fereshteh Taheri-Eilagh, Ulrich Mager, Annika Dejmek, Katalin Dobra, Hans Brunnström Abstract Objective: Traditionally, the diagnosis of pleural mesothelioma is based on histological material. Minimally invasive effusion cytology specimens are an alternative that, like biopsies, require ancillary analyses. Validation…
Read MoreClinically Occult Diffuse Pleural Mesothelioma in Patients Presenting With Spontaneous Pneumothorax
American Journal of Clinical Pathology 2023 May 31 [Link] Daffolyn Rachael Fels Elliott, Kristine E Konopka, Steven M Hrycaj, Kiran H Lagisetty, Jeffrey L Myers, Carol F Farver, Tao Huang Abstract Objectives: To report histologic features of unsuspected diffuse pleural mesothelioma (DPM) in surgical specimens for pneumothorax and demonstrate how ancillary markers support a diagnosis…
Read MoreImmunohistochemical expression of cAMP in fluoroedenite‑induced malignant pleural mesothelioma: Preliminary results
Molecular Medicine Reports 2023 July [Link] Giuseppe Broggi, Veronica Filetti, Gaetano Magro, Brunella Morante, Rossella Garro, Caterina Ledda, Venerando Rapisarda, Claudia Lombardo, Carla Loreto, Rosario Caltabiano Abstract Despite advances in understanding of the biology of malignant pleural mesothelioma (MPM), the prognosis of this malignancy remains poor. Although asbestos still remains the main pathogenic agent of…
Read MoreThe clinicopathological significance of TOP2A expression in malignant peritoneal mesothelioma
Annals of Diagnostic Pathology 2023 August [Link] Xuemei Du, Xinbao Li, Bingdong Zhang, Zechen Hao, Ying Gao, Xi Jiang, Zhiran Yang, Yizhi Chen Abstract Background: Malignant peritoneal mesothelioma (MPM) is a rare malignant tumor with a high mortality rate and extremely poor prognosis. TOP2A expression is associated with cell proliferation and cell cycle progression. We…
Read MoreCombination therapy with anti-programmed cell death 1 antibody plus angiokinase inhibitor exerts synergistic antitumor effect against malignant mesothelioma via tumor microenvironment modulation
Lung Cancer 2023 June [Link] Akio Tada, Toshiyuki Minami, Hidemi Kitai, Yoko Higashiguchi, Mayuko Tokuda, Tomoki Higashiyama, Yoshiki Negi, Daisuke Horio, Yasuhiro Nakajima, Taiichiro Otsuki, Koji Mikami, Ryo Takahashi, Akifumi Nakamura, Kazuhiro Kitajima, Masaki Ohmuraya, Kozo Kuribayashi, Takashi Kijima Abstract Malignant pleural mesothelioma (MPM) is an asbestos-related fatal malignant neoplasm. Although there has been no…
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