Concordance between CDKN2A homozygous deletion and MTAP immunohistochemical loss in fluoroedenite-induced pleural mesothelioma: An immunohistochemical and molecular study on a single-institution series

Pathology, Research, and Practice 2024 May 14 [Link] Giuseppe Broggi, Michele Massimino, Maria Failla, Veronica Filetti, Venerando Rapisarda, Caterina Ledda, Claudia Lombardo, Carla Loreto, Paolo Vigneri, Rosario Caltabiano Abstract Fluoroedenite-induced pleural mesothelioma (FE-induced-PM) is a rare and small subset of PM that shares with its asbestos-induced counterpart the same aggressive biological behavior and poor prognosis,…

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Concordance between CDKN2A homozygous deletion and MTAP immunohistochemical loss in fluoroedenite-induced pleural mesothelioma: An immunohistochemical and molecular study on a single-institution series

Pathology, Research, and Practice 2024 May 14 [Link] Giuseppe Broggi, Michele Massimino, Maria Failla, Veronica Filetti, Venerando Rapisarda, Caterina Ledda, Claudia Lombardo, Carla Loreto, Paolo Vigneri, Rosario Caltabiano Abstract Fluoroedenite-induced pleural mesothelioma (FE-induced-PM) is a rare and small subset of PM that shares with its asbestos-induced counterpart the same aggressive biological behavior and poor prognosis,…

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Comprehensive genomic profiling of pediatric peritoneal mesothelioma: case report with a literature review

Journal of Surgical Case Reports 2024 May 18 [Link] Jasmina Redzepagic, Zlatan Zvizdic, Nurija Bilalovic, Emir Milisic, Melika Bukvic, Semir Vranic Abstract Malignant peritoneal mesothelioma is an extremely rare and poorly recognized neoplasm in children. A 5-year-old boy presented with a 1-year history of progressive painless abdominal distension. A CT revealed a 19 × 19…

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Diagnostic Accuracy of Ultrasound Guided Percutaneous Pleural Needle Biopsy for Malignant Pleural Mesothelioma

Journal of Clinical Medicine 2024 April 29 [Link] Carlo Iadevaia, Vito D’Agnano, Raffaella Pagliaro, Felice Nappi, Raffaella Lucci, Simona Massa, Andrea Bianco, Fabio Perrotta Abstract Background/Objectives: Ultrasound (US) has been progressively spreading as the most useful technique for guiding biopsies and fine-needle aspirations that are performed percutaneously. Malignant pleural mesothelioma (MPM) represents the most common…

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BAP1 Deficiency Inflames the Tumor Immune Microenvironment and Is a Candidate Biomarker for Immunotherapy Response in Malignant Pleural Mesothelioma

JTO Clinical and Research Reports 2024 March 29 [Link] Duo Xu, Yanyun Gao, Haitang Yang, Marc Spils, Thomas M Marti, Tereza Losmanová, Min Su, Wenxiang Wang, Qinghua Zhou, Patrick Dorn, Yongqian Shu, Ren-Wang Peng Abstract Introduction: Malignant pleural mesothelioma (MPM) is a rare and universally lethal malignancy with limited treatment options. Immunotherapy with immune checkpoint…

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Pleural mesothelioma from fluoro-edenite exposure: PACAP and PAC1 receptor. A preliminary report

European Journal of Histochemistry 2024 May 2 [Link] Claudia Lombardo, Grazia Maugeri, Agata Grazia D’Amico, Giuseppe Broggi, Rosario Caltabiano, Veronica Filetti, Serena Matera, Velia D’Agata, Carla Loreto Abstract Pleural mesothelioma is a devastating malignancy primarily associated with asbestos exposure. However, emerging evidence suggests that exposure to fluoro-edenite fibers, a naturally occurring mineral fiber, can also…

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Diagnostic performance of immunohistochemistry markers for malignant pleural mesothelioma diagnosis and subtypes. A systematic review and meta-analysis

Pathology, Research, and Practice 2024 March 30 [Link] Rafael Parra-Medina, Juan Pablo Castañeda-González, Viviana Chaves-Cabezas, Juan Pablo Alzate, Juan José Chaves Abstract Background: Malignant pleural mesothelioma (MPM) poses diagnostic challenges due to its resemblance to benign pleural pathologies and different histological subtypes. Several immunohistochemistry markers have been employed to aid in accurate diagnosis. Methods: The…

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Guidelines for Pathologic Diagnosis of Mesothelioma

Archives of Pathology and Laboratory Medicine 2024 April 8 [Link] Aliya N Husain, David B Chapel, Richard Attanoos, Mary Beth Beasley, Luka Brcic, Kelly Butnor, Lucian R Chirieac, Andrew Churg, Sanja Dacic, Francoise Galateau-Salle, Kenzo Hiroshima, Yin P Hung, Sonja Klebe, Thomas Krausz, Andras Khoor, Leslie Litzky, Alberto Marchevsky, Kazuki Nabeshima, Andrew G Nicholson, Elizabeth…

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Characterization of pleural mesothelioma by hierarchical clustering analyses using immune cells within tumor microenvironment

Pathobiology 2024 March 25 [Link] Shingo Inaguma, Chengbo Wang, Sunao Ito, Akane Ueki, Jerzy Lasota, Piotr Czapiewski, Renata Langfort, Janusz Rys, Joanna Szpor, Piotr Waloszczyk, Krzysztof Okoń, Wojciech Biernat, Shuji Takiguchi, David S Schrump, Markku Miettinen, Satoru Takahashi Abstract Introduction: Over the past decade, classifications using immune cell infiltration have been applied to many types…

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