Immunohistochemistry or IHC
Diagnostic Challenges in the Pathological Approach to Pleural Mesothelioma
Cancers 2025 February 1 [Link] Stefano Lucà, Giovanna Pignata, Alessandro Cioce, Cecilia Salzillo, Rossella De Cecio, Gerardo Ferrara, Carminia Maria Della Corte, Floriana Morgillo, Alfonso Fiorelli, Marco Montella, Renato Franco Abstract Malignant pleural mesothelioma (MPM) still represents a complex diagnostic challenge for pathologists in routine practice. This diagnosis requires a multidisciplinary approach, and pathological evaluation…
Read MoreAnalysis of TERT mRNA Levels and Clinicopathological Features in Patients with Peritoneal Mesothelioma
Cancers 2025 January 14 [Link] Antonio d’Amati, Gabriella Serio, Andrea Quaranta, Luigi Vimercati, Michelina De Giorgis, Loredana Lorusso, Mariella Errede, Vito Longo, Andrea Marzullo, Domenico Ribatti, Tiziana Annese Abstract Background/objectives: Telomerase reverse transcriptase (TERT) is the catalytic subunit of the telomerase enzyme responsible for telomere length maintenance and is an important cancer hallmark. Our study…
Read MoreMetastatic Mesothelioma of the Tunica Vaginalis Presenting as Scrotal and Abdominal Nodules: A Case Report and Review of the Literature
The American Journal of Dermatopathology 2025 January 1 [Link] Aubre Gilbert, Rebekah Wieland, Natasha Zacher, Kerri Rieger, Gerald J Berry, Roberto Novoa Abstract Mesothelioma of the tunica vaginalis testis (MMTVT) is a rare neoplasm comprising <3% of all cases of malignant mesothelioma (MM). MMTVT derives from the tunica vaginalis testis, an outpouching of the mesothelial-lined…
Read MoreHigh endothelial venules in the pleura: MECA-79 expression in mesothelioma, pleural metastasis and pleuritis
Pathology, Research, and Practice 2024 November [Link] Ikram Kherrour, Mousa Mobarki, Michel Péoc’h, Georgia Karpathiou Abstract Introduction: High endothelial venules (HEVs) are vessels specialized in the extravasation of lymphocytes from the blood to the tissue implicated in the immune microenvironment of several tumors. Their presence has been never studied in the pleural tissue. Material and…
Read MoreChallenging the Norm: Occurrence of Synchronous Pleural and Peritoneal Mesothelioma in a Female Patient
Cureus 2024 August 18 [Link] Surendar Reddy, Kavya M G, Rakesh Gattu, Alekya P, Manasa Kuthadi Abstract Here, we present a unique case involving a female patient in her 40s with synchronous malignant pleural and peritoneal mesothelioma, despite lacking a history of asbestos exposure. The patient’s initial symptoms included dyspnoea, chest pain, cough, fever, appetite…
Read MoreImmunohistochemical Evaluation of Schlafen 11 (SLFN11) Expression in Cancer in the Search of Biomarker-Informed Treatment Targets: A Study of 127 Entities Represented by 6658 Tumors
The American Journal of Surgical Pathology 2024 August 26 [Link] Maciej Kaczorowski, Kris Ylaya, Małgorzata Chłopek, Daiki Taniyama, Yves Pommier, Jerzy Lasota, Markku Miettinen Abstract Schlafen 11 (SLFN11), a DNA/RNA helicase, acts as a regulator of cellular response to replicative stress and irreversibly triggers replication block and cell death. Several preclinical in vitro studies and…
Read MoreSTK11 (LKB1) immunohistochemistry is a sensitive and specific marker for STK11 adnexal tumours
Histopathology 2024 November [Link] Amir Dehghani, Aarti E Sharma, Stephanie E Siegmund, Chrystalle K Carreon, Colin J R Stewart, Fabiola Medeiros, Jelena Mirkovic, Marisa R Nucci, Christopher P Crum, Jason L Hornick, Brooke E Howitt, W Glenn McCluggage, David L Kolin Abstract Aims: STK11 adnexal tumour is a rare, recently described malignant neoplasm that is…
Read MoreCase report: ATM A1159T mutation in malignant peritoneal mesothelioma may be associated with tumor recurrence
SAGE Open Medical Case Reports 2024 August 16 [Link] Ying Li, Jintao Yang, Bei Zheng, Na Yan, Wenjuan Yang, Xinling Xie, Guoshu Xu, Meiling Zhang Abstract Malignant peritoneal mesothelioma is an exceedingly rare malignant tumor. Herein, we present a case of malignant peritoneal mesothelioma in a 59-year-old Chinese female patient who was stable after treatment…
Read MoreApplication of the international system for reporting serous fluid cytopathology on pleural effusion cytology with paired pleural biopsy: A new insight and novel approach on risk of malignancy
Cytopathology 2024 August 1 [Link] Zahra Maleki, Ashleigh J Graham, Robert Jones, Ricardo Pastorello, Paul Morris, Alessandra C Schmitt, Erika F Rodriguez Abstract Introduction: The risk of malignancy (ROM) remains an area of interest for further evaluation in reporting systems including in International System for reporting serous fluid cytopathology (TIS), which is a standardized system…
Read MoreMajor response of a peritoneal mesothelioma to nivolumab and ipilimumab: a case report, molecular analysis and review of literature
Frontiers in Oncology 2024 July 18 [Link] Marie-Florence Reveneau, Julien Masliah-Planchon, Manuel Fernandez, Abdenour Ouikene, Bernard Dron, Innocenti Dadamessi, Charles Dayen, Lisa Golmard, Bruno Chauffert Abstract Malignant peritoneal mesothelioma (MPM) is a rare tumor associated with a poor prognosis and a lack of consensus regarding treatment strategies. While the Checkmate 743 trial demonstrated the superiority…
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