Immunohistochemistry or IHC
High endothelial venules in the pleura: MECA-79 expression in mesothelioma, pleural metastasis and pleuritis
Pathology, Research, and Practice 2024 November [Link] Ikram Kherrour, Mousa Mobarki, Michel Péoc’h, Georgia Karpathiou Abstract Introduction: High endothelial venules (HEVs) are vessels specialized in the extravasation of lymphocytes from the blood to the tissue implicated in the immune microenvironment of several tumors. Their presence has been never studied in the pleural tissue. Material and…
Read MoreChallenging the Norm: Occurrence of Synchronous Pleural and Peritoneal Mesothelioma in a Female Patient
Cureus 2024 August 18 [Link] Surendar Reddy, Kavya M G, Rakesh Gattu, Alekya P, Manasa Kuthadi Abstract Here, we present a unique case involving a female patient in her 40s with synchronous malignant pleural and peritoneal mesothelioma, despite lacking a history of asbestos exposure. The patient’s initial symptoms included dyspnoea, chest pain, cough, fever, appetite…
Read MoreImmunohistochemical Evaluation of Schlafen 11 (SLFN11) Expression in Cancer in the Search of Biomarker-Informed Treatment Targets: A Study of 127 Entities Represented by 6658 Tumors
The American Journal of Surgical Pathology 2024 August 26 [Link] Maciej Kaczorowski, Kris Ylaya, Małgorzata Chłopek, Daiki Taniyama, Yves Pommier, Jerzy Lasota, Markku Miettinen Abstract Schlafen 11 (SLFN11), a DNA/RNA helicase, acts as a regulator of cellular response to replicative stress and irreversibly triggers replication block and cell death. Several preclinical in vitro studies and…
Read MoreSTK11 (LKB1) immunohistochemistry is a sensitive and specific marker for STK11 adnexal tumours
Histopathology 2024 November [Link] Amir Dehghani, Aarti E Sharma, Stephanie E Siegmund, Chrystalle K Carreon, Colin J R Stewart, Fabiola Medeiros, Jelena Mirkovic, Marisa R Nucci, Christopher P Crum, Jason L Hornick, Brooke E Howitt, W Glenn McCluggage, David L Kolin Abstract Aims: STK11 adnexal tumour is a rare, recently described malignant neoplasm that is…
Read MoreCase report: ATM A1159T mutation in malignant peritoneal mesothelioma may be associated with tumor recurrence
SAGE Open Medical Case Reports 2024 August 16 [Link] Ying Li, Jintao Yang, Bei Zheng, Na Yan, Wenjuan Yang, Xinling Xie, Guoshu Xu, Meiling Zhang Abstract Malignant peritoneal mesothelioma is an exceedingly rare malignant tumor. Herein, we present a case of malignant peritoneal mesothelioma in a 59-year-old Chinese female patient who was stable after treatment…
Read MoreApplication of the international system for reporting serous fluid cytopathology on pleural effusion cytology with paired pleural biopsy: A new insight and novel approach on risk of malignancy
Cytopathology 2024 August 1 [Link] Zahra Maleki, Ashleigh J Graham, Robert Jones, Ricardo Pastorello, Paul Morris, Alessandra C Schmitt, Erika F Rodriguez Abstract Introduction: The risk of malignancy (ROM) remains an area of interest for further evaluation in reporting systems including in International System for reporting serous fluid cytopathology (TIS), which is a standardized system…
Read MoreMajor response of a peritoneal mesothelioma to nivolumab and ipilimumab: a case report, molecular analysis and review of literature
Frontiers in Oncology 2024 July 18 [Link] Marie-Florence Reveneau, Julien Masliah-Planchon, Manuel Fernandez, Abdenour Ouikene, Bernard Dron, Innocenti Dadamessi, Charles Dayen, Lisa Golmard, Bruno Chauffert Abstract Malignant peritoneal mesothelioma (MPM) is a rare tumor associated with a poor prognosis and a lack of consensus regarding treatment strategies. While the Checkmate 743 trial demonstrated the superiority…
Read MoreUpdate on gene fusions and the emerging clinicopathological landscape of peritoneal and pleural mesotheliomas and other neoplasms
ESMO Open 2024 July 25 [Link] N Benzerdjeb, P Dartigues, V Kepenekian, F Damiola, R Sequeiros, F Galateau-Salle, H Begueret, E Mery, D Damotte, V Verriele, J Fontaine, S Isaac, S Valmary-Degano, L Villeneuve, O Glehen, A Scherpereel, F Forest, A De la Fourchardiere, S Paindavoine, A Hourlier, D Pissaloux, F Tirode, S Lantuejoul Abstract…
Read MoreCase Report: Primary malignant mesothelioma of the left atrium easily misdiagnosed as myxoma
Frontiers in Cardiovascular Medicine 2024 June 13 [Link] Shuai Luo, Yao Li, Jin Li, Jiafei Zeng, Jinjing Wang Abstract Background: Malignant mesothelioma (MM) is a rare and aggressive tumor that is found in the pleura and peritoneum. A few cases of MM in the pericardium and tunica vaginalis testis have been reported. Moreover, primary occurrence…
Read MoreDual Malignancies Discovered: A Rare Case of Malignant Peritoneal Epithelioid Mesothelioma and Lung Adenocarcinoma
Cureus 2024 May 9 [Link] Mark A Potesta Jr, Emma Guld, Jennifer Laman Abstract Clinicians diagnosing malignant peritoneal epithelioid mesothelioma (MPM or MPeM) have historically had challenges due to the low incidence of the disease, as well as the often vague symptomatology that patients present with. Newer advances in technology, specifically in immunocytochemistry, have provided…
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