Pleural Effusion
Extracellular stressors change BBSome expression of benign mesothelial and primary pleural mesothelioma cells and affect cell adhesion and migration
Physiological Reports 2026 June [Link] Rajesh M Jagirdar, Erasmia Rouka, Eleanna Pitaraki, Sotirios I Sinis, Charalambos Varsamas, Eleftherios D Papazoglou, Lydia Giannakou, Panagiotis I Tzamalas, Ourania S Kotsiou, Anastasios Giannou, Chrissi Hatzoglou, Najib M Rahman, Konstantinos I Gourgoulianis, Sotirios G Zarogiannis Abstract Pleural mesothelial cells have a primary cilium (PC), a solitary sensory organelle facing…
Read MoreA High-Fidelity Patient-Derived Organoid Platform Recapitulates the Dynamic Metabolic Landscape of Cisplatin Tolerance in Mesothelioma
Cancers 2026 May 7 [Link] Zivile Useckaite, Ashleigh J Hocking, Lauren A Mortimer, John Salamon, Simon Lee, Yazad Irani, Lucy Franzon, Arya L Arul, Sarita Prabhakaran, Sonja Klebe Abstract Background: Pleural mesothelioma (PM) is characterised by often rapid therapeutic failure and chemotherapy resistance. While terminal resistance is well studied, the initial transition into a drug-tolerant…
Read MoreThe Diagnostic Value of Immunohistochemistry and Biomarkers in the Diagnosis of Mesothelioma in Pleural/Peritoneal Effusions
Diagnostic Cytopathology 2026 May 20 [Link] Suzanne M Selvaggi Abstract Background: Mesothelioma is a rare tumor that arises from the serosal cells lining the serous cavities, most commonly the pleura followed by the peritoneum. Presenting symptoms include pleuritic pain and bloody effusions that recur. Although cytologic analysis cannot determine the mesothelial subtype or in situ…
Read MoreDiagnostic Yield of Malignant Pleural Effusion in Various Primary and Metastatic Cancers: Insights Across Cancer Subtypes
Pulmonary Medicine 2026 [Link] Santosh Basyal, Antony D Rawindraraj, Rahul Parajuli, Shardul Bhattarai, Laxman Wagle, Kritick Bhandari, Vikas Pathak Abstract Objective/background: Pleural fluid cytology remains a cornerstone in diagnosing malignant pleural effusions (MPEs); however, its diagnostic yield varies considerably across cancer subtypes. This study is aimed at evaluating the diagnostic performance of cytology stratified by…
Read MoreMedical thoracoscopy with talc poudrage and indwelling pleural catheter insertion versus medical thoracoscopy with talc poudrage alone for patients with symptomatic malignant pleural effusion (TACTIC): a randomised, controlled phase 3 trial
The Lancet. Respiratory Medicine 2026 April [Link] Alexandra Dipper, Anand Sundaralingam, Emma Hedley, Sharada Gudur, Janet Mills, Sandra Sowden, John P Corcoran, Cyrus Daneshvar, Chris Craig, Andrew J Moore, Alice Milne, Amelia Clive, Rahul Bhatnagar, Mark E Roberts, Thapas Nagarajan, Farheen Kutubudin, Helen Wassal, Moustafa Aboushehata, Sana Iftikhar, Mohammed Haris, Manjumol Abraham, Rajini Sudhir, Rakesh…
Read MorePleural Fluid Cytology-Histology Correlation in Patients With Malignant Pleural Mesothelioma: A Series of 26 Cases
Cytopathology 2026 February 20 [Link] John Findley, Matthew Demetrious, Lucas Yan, Lei Yan Abstract Background: To understand the efficacy of pleural effusion cytology in the diagnosis of malignant mesothelioma, we conducted this retrospective study to review the pleural fluid cytologies of patients diagnosed on concurrent/recent pleural biopsy histology. The clinicopathologic features and common cytomorphology were…
Read MoreBAP-1 in the diagnosis of malignant pleural mesothelioma
Respiratory Medicine and Research 2025 November 28 [Link] Irene Sansano, Ana Vázquez, Oscar Persiva, Marc Simó, Leire Sánchez, Pilar Montoya, Carme Dinarès, Carmen Alemán Abstract Background: The diagnosis of malignant pleural mesothelioma (MPM) can be challenging for clinicians and pathologists. Patients and methods: This study included all patients diagnosed with pleural mesothelioma between October 2013…
Read MoreThe specificity of HEG1 as mesothelioma marker depends on the differential diagnosis
Virchows Archiv 2026 March [Link] Ben Davidson, Lara Maria Stričak, Arild Holth, Annette Torgunrud, Jeremias Wohlschlaeger, Martin Tötsch , Assia Bassarova Abstract The objective of this study was to analyze the diagnostic role of HEG homolog 1 (HEG1) in cancers affecting the serosal cavities. HEG1 protein expression by immunohistochemistry was analyzed in 534 specimens (341…
Read MoreAdverse Renal Outcomes in Patients With Mesothelioma-A Territory-Wide Real-World Data
Cancer Medicine 2026 February [Link] Wang Chun Kwok, James Chung Man Ho, Isaac Sze Him Leung, Desmond Yat Hin Yap Abstract Introduction: Advances in mesothelioma management have translated into longer patient survival and different treatment-related side effects including nephrotoxicity. The risk of developing adverse renal outcomes in patients with mesothelioma and associated risk factors remains…
Read MoreTime to next procedure in patients with malignant pleural effusion undergoing aspiration: derivation and initial validation of the RED score
Thorax 2026 January 28 [Link] Eleanor K Mishra, Helen Davies, Syed Hamza Abbas, Cheryl Hardy, Dominic T Beith, Dheeraj Sethi, Toshit Sapkal, Alguili Elsheikh, Asfandyar Yousuf, Emma L Hedley, Ellie Daly, Anand Sundaralingam, Dinesh Addala, Samantha A Jones, Lianne Castle, Neena Patel, Jurgen Herre, Hannah Collins, Jack Kastelik, Clare L Ross, John Corcoran, Cyrus Daneshvar,…
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