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Epithelioid Mesothelioma Cells Exhibit Increased Ferroptosis Sensitivity Compared to Non-Epithelioid Mesothelioma Cells
Cancers 2025 December 13 [Link] Tatsuhiro Sato, Ikue Hasegawa, Haruna Ikeda, Taichi Ohshiro, Lisa Kondo-Ida, Satomi Mukai, Satoshi Ohte, Tohru Maeda, Yoshitaka Sekido Abstract Background/Objectives: Mesothelioma is a highly aggressive tumor with a poor prognosis that typically develops after a long latency period following asbestos exposure. Although immunotherapy combined with chemotherapy is increasingly used, the…
Read MoreDeterminants of Response to Immune Checkpoint Blockade in Pleural Mesothelioma: Molecular, Immunological, and Clinical Perspectives
Cancers 2025 December 17 [Link] Martina Delsignore, Gaia Cassinari, Simona Revello, Luigi Cerbone, Federica Grosso, Marcello Arsura, Chiara Porta Abstract Diffuse pleural mesothelioma (PM) is a rare thoracic malignancy with historically limited treatment options and poor outcomes. Despite the recent breakthrough of dual immune checkpoint blockade (ICB)-notably the combination of anti-PD-1 and anti-CTLA-4 therapies-clinical responses…
Read MoreCytopathologic Features of Metastatic Malignant Mesothelioma With SMARCB1 (INI-1) Deficient Diagnosed by Ultrasound-Guided Fine-Needle Aspiration: A Case Report
Diagnostic Cytopathology 2025 December 29 [Link] Jun Yang, Juandi Liu, Jing Jin, Deng Pan, Lei Shao Abstract Malignant mesothelioma (MM) is a rare yet aggressive neoplasm that arises from mesothelial cells lining the thoracic and abdominal cavities, the pericardium, and the tunica testis. Characterized by rapid progression, high invasiveness, and a poor prognosis, MM poses…
Read MoreThe Role of Radiotherapy After Pleurectomy/Decortication for Malignant Pleural Mesothelioma: State of the Art
Journal of Personalized Medicine 2025 December 1 [Link] Marco Andolfi, Michele Salati, Majed Refai Abstract Background: Considering the increased need to deliver adjuvant radiotherapy (RT) after pleurectomy/decortication (P/D) for malignant pleural mesothelioma (MPM) without exceeding the tolerance of the adjacent normal tissue, new advanced RT technologies have been developed. However, radiation to the whole hemithorax…
Read MoreMerlin Immunohistochemistry Is Useful in the Differential Diagnosis of Epithelioid Mesothelioma and Reactive Mesothelial Hyperplasia
Pathology International 2026 January [Link] Kohei Aoe, Kei Kushitani, Vishwa Jeet Amatya, Tetsuya Nakagiri, Yoshihiro Miyata, Morihito Okada, Yukio Takeshima Abstract The differential diagnosis of epithelioid mesothelioma and reactive mesothelial hyperplasia can be challenging based on morphology alone, particularly in small specimens. Consequently, the use of ancillary techniques, such as immunohistochemistry for BRCA1-associated protein 1,…
Read MoreThe INDEPSO-ISPSM Consensus on Peritoneal Malignancies-Diagnosis and Management of Peritoneal Mesothelioma
Indian Journal of Surgical Oncology 2025 December [Link] Ambarish Chatterjee, Ashwin K Rajagopal, Vivekanand Sharma, Niharika Garach, Ninad Katdare, Rohit Kumar, Swapnil Patel, Mukurdipi Ray, Somashekhar Sp, Sanket Mehta, Vivek Sukumar, Aditi Bhatt Abstract We report the results of a consensus exercise covering the basics of management of peritoneal mesothelioma (PeM) (diagnostic evaluation, patient selection…
Read MoreCo-occurrence of peritoneal mesothelioma and genitourinary cancers: a case series with comparative outcomes
Pleura and Peritoneum 2025 November 3 [Link] Emma M Bradley, James L Rogers, Marissa C Kuo, Deepa Magge Abstract Objectives: Peritoneal mesothelioma (PM) shares features with genitourinary (GU) malignancies, including histologic appearance, embryologic origin and genetic predispositions. However, data on their co-occurrence are limited. The study presents a case series of PM patients with associated…
Read MoreDiagnostic potential of a novel immunohistochemical marker, GFPT2, in differentiating mesothelioma from its morphological mimics
Histopathology 2025 December 15 [Link] Jia Wei, Xiaofang Ma, Gang Chen, Yan Wang, Qinhe Fan, Qixing Gong Abstract Aims: Mesothelioma (MESO) is a rare and aggressive tumour originating from mesothelial cells, primarily affecting the pleura and peritoneum. Its diagnosis remains challenging due to non-specific clinical, radiological and histopathological features, compounded by morphological diversity and overlapping…
Read MoreGlobal patterns and trends in mesothelioma incidence: A retrospective cross-sectional study
Lung Cancer 2026 January [Link] Leiwen Fu, Ke Liu, Yang Liu, Yanxiao Gao, Bingyi Wang, Yuxian Sun, Wei Shu, Yujia Ning, Minyi Zhang, Jian Du, Liang Li Abstract Background: Mesothelioma is a rare and aggressive malignancy primarily caused by asbestos exposure; it predominantly affects older adults with a history of occupational contact. Methods: This population-based…
Read MoreCurcumin impacts on cisplatin sensitivity determining apoptotic boost in mesothelioma
Biomedicine & Pharmacotherapy 2025 December [Link] Miriam Piccioni, Emilia Caputo, Rossana Cuciniello, Francesco Di Meo, Anna Valentino, Gianluigi Petillo, Elena Rinaldi, Orsolina Petillo, Alfonso Baldi, Stefania Filosa, Paolo Bergamo, Stefania Crispi Abstract Cancer is one of the main diseases causing one-third of the worldwide death every year. The recent progresses achieved in chemotherapy have increased…
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