Dendritic cells loaded with allogeneic tumour cell lysate plus best supportive care versus best supportive care alone in patients with pleural mesothelioma as maintenance therapy after chemotherapy (DENIM): a multicentre, open-label, randomised, phase 2/3 study

The Lancet Oncology 2024 June 4 [Link] Joachim G Aerts, Robert Belderbos, Paul Baas, Arnaud Scherpereel, Koen Bezemer, Ilona Enninga, Rob Meijer, Marcella Willemsen, Rossana Berardi, Dean Fennell, Rene Kerstens, Robin Cornelissen 2, Jan P van Meerbeeck Abstract Background: Dendritic cell immunotherapy has proven to be safe and induces an immune response in humans. We…

Read More

Comparative efficacy of immune checkpoint inhibitors versus chemotherapy alone in diffuse pleural mesothelioma

Thoracic Cancer 2024 June 5 [Link] Xuemei Zhang, Lele Chang, Qian Ma, Qian Zhang, Wansu Xu, Qingwei Li Abstract Background: This study aimed to investigate the effects of immune checkpoint inhibitors (ICIs) versus chemotherapy on the prognosis of real-world diffuse pleural mesothelioma patients in China. Methods: Clinical data of 90 patients with diffuse pleural mesothelioma…

Read More

A randomised phase II study of extended pleurectomy/decortication (e-PD) preceded or followed by chemotherapy in patients (pts) with early-stage pleural mesothelioma (PM): EORTC 1205

The European Respiratory Journal 2024 June 26 [Link] Jo Raskin, Veerle Surmont, Alexander P W M Maat, Maha Yahia, Sjaak A Burgers, Yassin Pretzenbacher, Frederic De Ryck, Robin Cornelissen, Houke M Klomp, Ana Oliveira, Joachim Aerts, Paul Baas, Sandrine Marreaud, Jan P Van Meerbeeck, Paul E Y Van Schil Abstract Background: The role of surgery…

Read More

Current clinical practices of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)

Innovative Surgical Sciences 2024 March 14 [Link] Miklos Acs, Maximilian Babucke, Maximilian Jusufi, Zsolt Kaposztas, Przemyslaw Slowik, Matthias Hornung, Hans J Schlitt, Ivan Panczel, Judit Hevesi, Jonas Herzberg, Tim Strate, Pompiliu Piso Abstract Treatment of peritoneal surface malignancies makes physicians face demanding and new-fangled problems, as there are many uncertain aspects considering the outcomes of…

Read More

FK228 suppress the growth of human malignant pleural mesothelioma tumor independent to epithelioid or non-epithelioid histology

Molecular Medicine 2024 May 31 [Link] James Mei-Lin Chan, Yuan-Ching Chang, Hua-Chen Chan, Hsiu-Chuan Chan, Wei-Chin Chang, Liu-Fang Wang, Tung-Hu Tsai, Yu-Jen Chen, Wen-Chien Huang Abstract Human malignant pleural mesothelioma (hMPM) is an aggressive, rare disease with a poor prognosis. Histologically, MPM is categorized into epithelioid, biphasic, and sarcomatoid subtypes, with the epithelioid subtype generally…

Read More

Sarcomatoid malignant pleural mesothelioma: a case of long-term recurrence-free survival following curative intent surgery alone

Surgical Case Reports 2024 May 31 [Link] Masatoshi Kanayama, Masaru Takenaka, Katsuma Yoshimatsu, Hiroki Matsumiya, Masataka Mori, Koji Kuroda3, Aya Nawata, Manabu Yasuda, Fumihiro Tanaka Abstract Background: Curative intent surgery may be indicated for some patients with resectable early stage malignant pleural mesothelioma (MPM). However, sarcomatoid MPM is a highly aggressive subtype for which curative…

Read More

Predictive potential of MRI in differentiating the predominant component in biphasic pleural mesothelioma

European Journal of Radiology 2024 May 26 [Link] Ritu R Gill, William G Richards, Hillary Heiling, Emanuele Mazzola, Yin P Hung, Ravi T Seethamraju, Lucian R Chirieac, Raphael Bueno Abstract Purpose: To assess the potential of apparent diffusion coefficient (ADC) values derived from diffusion weighted (DW) MRI preoperatively to predict the predominant histologic component among…

Read More

Analysis of Treatment Strategies and Outcomes in Malignant Peritoneal Mesothelioma: Insights From a Multi-Center Study

Annals of Surgical Oncology 2024 May 28 [Link] Serkan Yaşar, Feride Yılmaz, Güngör Utkan, Efnan Algın, Doğan Bayram, Selim Tamam, Ömür Berna Çakmak Öksüzoğlu, Ayşegül İlhan, Efe Cem Erdat, Ali Ekrem Ünal, Şuayib Yalçın Abstract Background: This study aimed to evaluate the demographic,” clinicopathologic, and prognostic characteristics of malignant peritoneal mesothelioma (MPeM), as well as…

Read More

Mesothelioma-Associated Fibroblasts Modulate the Response of Mesothelioma Patient-Derived Organoids to Chemotherapy via Interleukin-6

International Journal of Molecular Sciences 2024 May 14 [Link] Mario Cioce, Veronica Gatti, Fabiana Napolitano, Noemi Maria Giorgiano, Andrea Marra, Giuseppe Portella, Alfonso Fiorelli, Francesca Pentimalli, Vito Michele Fazio Abstract Malignant pleural mesothelioma (MPM) remains an incurable disease. This is partly due to the lack of experimental models that fully recapitulate the complexity and heterogeneity…

Read More