Type of Assessment:
Development of Patient and Caregiver Conceptual Models Investigating the Health-Related Quality of Life Impacts of Malignant Pleural Mesothelioma
The Patient 2024 April 15 [Link] Adam E J Gibson, Waqas Ahmed, Louise Longworth, Bryan Bennett, Melinda Daumont, Liz Darlison Abstract Background: Malignant pleural mesothelioma (MPM) is a rare and usually fatal malignancy frequently linked to occupational asbestos exposures and associated with poor prognosis and considerable humanistic burden. The study aimed to develop conceptual models…
Read MoreEmerging New Targets in Systemic Therapy for Malignant Pleural Mesothelioma
Cancers 2024 March 22 [Link] Karen M Yun, Lyudmila Bazhenova Abstract Malignant pleural mesothelioma (MPM) is a heterogeneous cancer composed of distinct molecular and pathologic subtypes. Unfortunately, MPM is aggressive, and current therapies for advanced, unresectable disease remain limited to cytotoxic chemotherapy and immunotherapy. Our understanding of the genomic landscape of MPM is steadily growing,…
Read MoreDiagnostic performance of immunohistochemistry markers for malignant pleural mesothelioma diagnosis and subtypes. A systematic review and meta-analysis
Pathology, Research, and Practice 2024 March 30 [Link] Rafael Parra-Medina, Juan Pablo Castañeda-González, Viviana Chaves-Cabezas, Juan Pablo Alzate, Juan José Chaves Abstract Background: Malignant pleural mesothelioma (MPM) poses diagnostic challenges due to its resemblance to benign pleural pathologies and different histological subtypes. Several immunohistochemistry markers have been employed to aid in accurate diagnosis. Methods: The…
Read MoreLow Exposures to Amphibole or Serpentine Asbestos in Germline Bap1-mutant Mice Induce Mesothelioma Characterized by an Immunosuppressive Tumor Microenvironment
Cancer Research Communications 2024 April 8 [Link] Yuwaraj Kadariya, Eleonora Sementino, Maggie Ruan, Mitchell Cheung, Parham Hadikhani, Hatice U Osmanbeyoglu, Andres J Klein-Szanto, Kathy Cai, Joseph R Testa Abstract Asbestos and BAP1 germline mutations are risk factors for malignant mesothelioma (MM). While it is well accepted that amphibole asbestos is carcinogenic, the role of serpentine…
Read MoreThe role of cytoreductive surgery and HIPEC for the treatment of primary and secondary peritoneal malignancies-experience from a tertiary care center in Germany
Langenbeck’s Archives of Surgery 2024 April 8 [Link] Mikko Reese, Ann-Kathrin Eichelmann, Tobias M Nowacki , Andreas Pascher, Judith C Sporn Abstract Purpose: Peritoneal surface malignancies (PSM) are commonly known to have a dismal prognosis. Over the past decades, novel techniques such as cytoreductive surgery (CRS), hyperthermic intraperitoneal chemotherapy (HIPEC), and pressurized intraperitoneal aerosol chemotherapy…
Read MoreGuidelines for Pathologic Diagnosis of Mesothelioma
Archives of Pathology and Laboratory Medicine 2024 April 8 [Link] Aliya N Husain, David B Chapel, Richard Attanoos, Mary Beth Beasley, Luka Brcic, Kelly Butnor, Lucian R Chirieac, Andrew Churg, Sanja Dacic, Francoise Galateau-Salle, Kenzo Hiroshima, Yin P Hung, Sonja Klebe, Thomas Krausz, Andras Khoor, Leslie Litzky, Alberto Marchevsky, Kazuki Nabeshima, Andrew G Nicholson, Elizabeth…
Read MorePrognostic significance of inflammation scores in malignant mesothelioma
European Review for Medical and Pharmacological Sciences 2024 March [Link] E Mutlu, M Inanc Abstract Objective: The relationship between inflammatory markers and survival in many cancers has been investigated previously. Inflammatory markers may also offer the possibility of predicting surveillance in patients with malignant mesothelioma. Our study seeks to enhance comprehension of how variables such…
Read MoreEstablishing mesothelioma patient-derived organoid models from malignant pleural effusions
Lung Cancer 2024 March 28 [Link] Ashleigh J Hocking, Lauren A Mortimer, Alexandra L Farrall, Prudence A Russell, Sonja Klebe Abstract Objectives: Pleural mesothelioma is a cancer arising in the cells that line the lungs and chest wall with poor survival and poor response to first-line therapy. Organoid models of cancer can faithfully recapitulate the…
Read MoreImplementation of a high-resolution, high-contrast magnetic resonance imaging protocol with extended delayed phases for peritoneal mesothelioma
Quantitative Imaging in Medicine and Surgery 2024 March 15 [Link] Milica Medved, Hunter D D Witmer, Ankit Dhiman, Yaniv Berger, Scott K Sherman, Enal S Hindi, Samuel G Armato 3rd, Ingrid S Reiser, Aytekin Oto, Roger M Engelmann, Hedy L Kindler, Nisa C Oren, Carla B Harmath, Kiran K Turaga Abstract Background: Imaging of peritoneal…
Read MoreCharacterization of pleural mesothelioma by hierarchical clustering analyses using immune cells within tumor microenvironment
Pathobiology 2024 March 25 [Link] Shingo Inaguma, Chengbo Wang, Sunao Ito, Akane Ueki, Jerzy Lasota, Piotr Czapiewski, Renata Langfort, Janusz Rys, Joanna Szpor, Piotr Waloszczyk, Krzysztof Okoń, Wojciech Biernat, Shuji Takiguchi, David S Schrump, Markku Miettinen, Satoru Takahashi Abstract Introduction: Over the past decade, classifications using immune cell infiltration have been applied to many types…
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