Combined detection of SHOX2 and PTGER4 methylation with serum marker CYFRA21-1 for improved diagnosis of malignant pleural mesothelioma

Journal of Clinical Pathology 2024 July 26 [Link] Nana Zhang, Yongmeng Li, Zuyu Sun, Yujie Dong, Lijuan Zhou, Chen Zhang, Zichen Liu, Qiuyi Zhang, Kun Li, Fudong Xu, Li Zhang, Bin She, Xiaosha Ren, Nanying Che Abstract Aims: To investigate the performance of a combined biomarker approach using the methylation status of the short stature…

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Leucine rich α2 glycoprotein 1 derived from malignant pleural mesothelioma cells facilitates macrophage M2 phenotypes

Experimental Lung Research 2024 [Link] Dandan Wang, Wenjing Pei, Yanfei Liu, Rongliang Mo, Xinru Li, Wenhui Gu, Yi Su, Jing Ye, Jiegou Xu, Dahai Zhao Abstract Background: Macrophages constitute the main part of infiltrating immune cells in Malignant pleural mesothelioma (MPM) and abnormally high ratios of M2 macrophages are present in both pleural effusion and…

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A Rare Case of Pleural Epithelioid Mesothelioma With a Prominent Myxoid Stroma Reported With Morphology, Fluorescent In Situ Hybridization, and Ultrastructural Findings

Cureus 2024 June 12 [Link] Hiroshi Sonobe, Rika Omote, Toshiyuki Habara, Kazuhiro Washio, Nobuyoshi Yamazoe, Shinji Matsumoto, Kazuki Nabeshima, Hiroko Toda Abstract Herein, we report a rare case of pleural epithelioid malignant mesothelioma with a prominent myxoid stroma. To date, detailed morphological or molecular pathological findings have not been reported for this type of tumor.…

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Characterizing soluble immune checkpoint molecules and TGF-β1,2,3 in pleural effusion of malignant pleural mesothelioma

Scientific Reports 2024 July 10 [Link] Riki Okita, Tomoya Senoo, Yuka Mimura-Kimura, Yusuke Mimura, Tomoyuki Murakami, Eiji Ikeda, Masanori Okada, Hidetoshi Inokawa, Keisuke Aoe Abstract The clinical impact of soluble molecules in pleural effusion (PE) is unclear in patients with malignant pleural mesothelioma (MPM). In this single-center, retrospective, observational study, we assessed soluble forms of…

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A rare case of a huge malignant pleural mesothelioma presenting in the posterior mediastinum

Respirology Case Reports 2024 July 9 [Link] Yuta Mori, Chihiro Kato, Hideo Yamakawa, Mariko Sugiura, Kensuke Fukumitsu, Satoshi Fukuda, Yoshihiro Kanemitsu, Takehiro Uemura, Tomoko Tajiri, Hirotsugu Ohkubo, Yutaka Ito, Tetsuya Oguri, Takayuki Murase, Akio Niimi Abstract We report a case of a 69-year-old woman with pleural mesothelioma presenting in the posterior mediastinum with a maximum…

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Review on treatment of pleural metastasis and malignant pleural effusion with Pressurized IntraThoracic Aerosol Chemotherapy (PITAC)

Pleura and Peritoneum 2024 May 17 [Link] Pernille Schjødt Hansen, Martin Graversen, Sönke Detlefsen, Michael Bau Mortensen Abstract Background: Malignant pleural effusion (MPE) is a common and debilitating condition seen in advanced cancer disease, and life-expectancy is short. Symptoms include pain and severe shortness of breath. Current first-line treatment options include pleural drainage using catheters…

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Leveraging the pleural space for anticancer therapies in pleural mesothelioma

The Lancet Respiratory Medicine 2024 May 10 [Link] Kevin G Blyth, Prasad S Adusumilli, Philippe Astoul, Liz Darlison, Y C Gary Lee, Aaron S Mansfield, Stefan J Marciniak, Nick Maskell, Vasiliki Panou, Tobias Peikert, Najib M Rahman, Marjorie G Zauderer, Daniel Sterman, Dean A Fennell Abstract Most patients with pleural mesothelioma (PM) present with symptomatic…

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