Symptoms & Symptom Management
Time to next procedure in patients with malignant pleural effusion undergoing aspiration: derivation and initial validation of the RED score
Thorax 2026 January 28 [Link] Eleanor K Mishra, Helen Davies, Syed Hamza Abbas, Cheryl Hardy, Dominic T Beith, Dheeraj Sethi, Toshit Sapkal, Alguili Elsheikh, Asfandyar Yousuf, Emma L Hedley, Ellie Daly, Anand Sundaralingam, Dinesh Addala, Samantha A Jones, Lianne Castle, Neena Patel, Jurgen Herre, Hannah Collins, Jack Kastelik, Clare L Ross, John Corcoran, Cyrus Daneshvar,…
Read MoreComparative analysis of malignant pleural effusion and peripheral blood reveals unique T cell signatures associated with survival in mesothelioma patients
Oxford Open Immunology 2025 December 24 [Link] Nicola Principe, Kofi L P Stevens, Amber-Lee Phung, Melanie McCoy, Joel Kidman, Ali Ismail, Alistair M Cook, Abha Chopra, Mark Watson, Bruce W Robinson, Jenette Creaney, Y C Gary Lee, Jason Waithman, W Joost Lesterhuis, Richard A Lake, Anna K Nowak, Jonathan Chee, Alison M McDonnell Abstract The…
Read MoreRisk Factors of Hematological Toxicity of Mesothelioma Treatment-A Territory-Wide Retrospective Study
Thoracic Cancer 2026 January [Link] Wang Chun Kwok, Desmond Yat Hin Yap, Isaac Sze Him Leung, James Chung Man Ho Abstract Background: While chemotherapy remains the treatment of choice for mesothelioma, it carries significant toxicities, especially hematological toxicity. Methods: We conducted this territory-wide retrospective study in Hong Kong to investigate the prevalence and risk factors…
Read MoreArtificial Intelligence in Pleural Diseases: Current Applications and Next Steps
Thoracic Research and Practice 2026 January 30 [Link] Ferhan Karataş, Öner Dikensoy Abstract Pleural diseases pose a significant burden on healthcare systems due to diagnostic challenges and high costs. Artificial intelligence (AI) has the potential to provide faster, more accurate, and more reliable results in the diagnosis of these diseases. This review evaluates the current…
Read MoreA novel malignant mesothelioma organoids-T cell co-culture platform for personalized immunochemotherapy testing
Scientific Reports 2025 November 21 [Link] Yang Liu, Yang Yang, Songlin An, Hua Wan, Minghao Zhang, Ruihong Yin, Weiting Zhao, Li Huang, Yunshan Zhao, Chenggang Li Abstract Malignant mesothelioma (MM) is a rare, aggressive cancer with poor outcomes due to its heterogeneity and therapy resistance. Patient-derived organoids (PDOs) have emerged as a promising tool for…
Read MoreDiffuse intrapulmonary malignant mesothelioma (DIMM) mimicking interstitial lung disease. Ultrastructural analysis and the potential role of the Hedgehog signaling pathway
Ultrastructural Pathology 2025 [Link] Hector Chavarria, Mohamed Zedan, Osama Elkadi, Kurt Knowles, Guillermo Herrera Abstract Diffuse intrapulmonary malignant mesothelioma (DIMM) is a rare variant of epithelioid mesothelioma characterized by diffuse lung parenchymal involvement without a discrete pleural mass, often mimicking interstitial lung disease (ILD). We report a case of a 55-year-old male presenting with bilateral…
Read MoreEnhanced efficacy of immune checkpoint inhibitors with OK-432 in malignant pleural mesothelioma: A case report
Molecular and Clinical Oncology 2025 July 3 [Link] Kazuki Yamada, Takehiro Uemura, Aya Mukai, Tatsuya Tanaka, Ippei Sakakibara, Keima Ito, Yuta Mori, Kensuke Fukumitsu, Satoshi Fukuda, Yoshihiro Kanemitsu, Tomoko Tajiri, Yutaka Ito, Tetsuya Oguri, Akio Niimi Abstract Malignant pleural mesothelioma (MPM) is a rare and highly aggressive cancer with limited treatment options and poor prognosis.…
Read MoreThe Evolving Role of Chemotherapy in the Management of Pleural Malignancies: Current Evidence and Future Directions
Cancers 2025 June 25 [Link] Yuliya Semenova, Zhandos Burkitbayev, Nurtas Kalibekov, Alexandr Digay, Bakhyt Zhaxybayev, Oxana Shatkovskaya, Saule Khamzina, Dinara Zharlyganova, Zhuldyz Kuanysh, Almira Manatova Abstract Pleural malignancies represent a clinically devastating group of oncological disorders, most commonly arising from metastatic disease, with lung and breast cancers being the most frequent primary sites. Malignant pleural…
Read MoreMedical Thoracoscopy in Malignant Pleural Effusion
Cureus 2025 June 10 [Link] Amit K Rath, Sudarsan Pothal, Pallavi Bharadwaj Abstract Introduction: Malignant pleural effusion (MPE) is a common complication of advanced malignancies, often resulting in significant morbidity and impaired quality of life. In most cases, pleural fluid cytology remains negative. In the era of targeted cancer therapy, pathologists expect larger tissue samples.…
Read MoreFibulin-3 in plasma and pleural effusion as a biomarker of mesothelioma
Radiology and Oncology 2025 June 16 [Link] Katja Adamic, Mateja Marc Malovrh, Urska Bidovec Stojkovic, Ales Rozman Abstract Background: Malignant pleural mesothelioma (MPM) is a global health concern linked to asbestos exposure. In Slovenia, regions with high asbestos exposure rates make MPM a significant public health issue. Although thoracoscopic biopsy is the gold standard for…
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