Symptoms & Symptom Management
Complications and Predictive Factors for Air Leak > 10 Days with Neoadjuvant Chemotherapy Followed by Pleurectomy/Decortication for Malignant Pleural Mesothelioma
Annals of Surgical Oncology 2020 October [Link] Akifumi Nakamura, Nobuyuki Kondo, Toru Nakamichi, Masaki Hashimoto, Teruhisa Takuwa, Seiji Matsumoto, Kozo Kuribayashi, Takashi Kijima, Seiki Hasegawa Abstract Background: A few studies have reported the incidence and clinical implications of complications after pleurectomy/decortication (P/D). Objective: The aim of this study was to assess the details of complications…
Read MoreThe phosphatase PTPN1/PTP1B is a candidate marker of better chemotherapy response in metastatic high-grade serous carcinoma
Cytopathology 2020 October 6 [Link] Ben Davidson, Annika Jøntvedt Bock, Arild Holth, Dag Andre Nymoen Abstract Objective: To analyze the expression and clinical role of the phosphatase PTPN1 (PTP1B) in serous effusions. Methods: PTPN1 mRNA expression by quantitative RT-PCR was analyzed in 83 high-grade serous carcinoma (HGSC) and 15 malignant mesothelioma (MM) effusions. PTP1B and…
Read MoreUsing creative co-design to develop a decision support tool for people with malignant pleural effusion
BMC Medical Informatics and Decision Making 2020 August 5 [Link] Cheryl Grindell, Angela Tod, Remi Bec, Daniel Wolstenholme, Rahul Bhatnagar, Parthipan Sivakumar, Anna Morley, Jayne Holme, Judith Lyons, Maryam Ahmed, Susan Jackson, Deirdre Wallace, Farinaz Noorzad, Meera Kamalanathan, Liju Ahmed, Mathew Evison Abstract Background: Malignant pleural effusion (MPE) is a common, serious problem predominantly seen…
Read MoreTesting for BAP1 loss and CDKN2A/p16 homozygous deletion improves the accurate diagnosis of mesothelial proliferations in effusion cytology
Cancer Cytopathology 2020 July 17 [Link] Martin Chevrier, Sara E Monaco, Jacob A Jerome, Francoise Galateau-Salle, Andrew Churg, Sanja Dacic Abstract Background: A number of ancillary tests have been developed that aid in the diagnosis of mesothelioma in cytology specimens. The aim of this retrospective study was to determine whether testing for BAP1 and CDKN2A/p16…
Read MoreInvolvement of the M-CSF/IL-34/CSF-1R Pathway in Malignant Pleural Mesothelioma
Journal for the Immunotherapy of Cancer 2020 June [Link] Thibaut Blondy, Sènan Mickael d’Almeida, Tina Briolay, Julie Tabiasco, Clément Meiller, Anne-Laure Chéné, Laurent Cellerin, Sophie Deshayes, Yves Delneste, Jean-François Fonteneau, Nicolas Boisgerault, Jaafar Bennouna, Marc Grégoire, Didier Jean, Christophe Blanquart Abstract Background: Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer related to asbestos…
Read MoreSecondary Renal Amyloidosis Associated With Asbestos-Related Pleuropulmonary Diseases
CEN Case Reports 2020 June 13 [Link] Ryoko Shibata, Tomomi Ozaki, Kazuhiro Tada, Takashi Aoyama, Maho Watanabe, Naoko Himuro, Koji Takahashi, Kenji Ito, Tetsuhiko Yasuno, Katsuhisa Miyake, Kosuke Masutani, Noriko Uesugi, Kazuki Nabeshima, Hitoshi Nakashima Abstract Here, we present a 67-year-old Japanese man who developed insidious-onset nephrotic syndrome. He had a history of occupational asbestos…
Read MoreGenomic-based Ancillary Assays Offer Improved Diagnostic Yield of Effusion Cytology With Potential Challenges in Malignant Pleural Mesothelioma
Pathology International 2020 June 15 [Link] Yoshiaki Kinoshita, Makoto Hamasaki, Shinji Matsumoto, Masayo Yoshimura, Ayuko Sato, Tohru Tsujimura, Toshiaki Kamei, Kunimitsu Kawahara, Kazuki Nabeshima Abstract BRCA1-associated protein 1 (BAP1) or methylthioadenosine phosphorylase (MTAP) immunohistochemistry (IHC) or 9p21 fluorescence in situ hybridization (FISH) are useful for the diagnosis of malignant pleural mesothelioma (MPM). However, the effect…
Read MoreHEG1, BAP1, and MTAP Are Useful in Cytologic Diagnosis of Malignant Mesothelioma With Effusion
Diagnostic Cytopathology 2020 May 22 [Link] Kenzo Hiroshima, Di Wu, Shinji Hamakawa, Shingo Tsuruoka, Daisuke Ozaki, Hideki Orikasa, Mizue Hasegawa, Eitetsu Koh, Yasuo Sekine, Yoko Yonemori, Kazuki Nabeshima, Shoutaro Tsuji, Yohei Miyagi, Kohzoh Imai Abstract Background: The specificity and sensitivity of HEG1 for malignant mesothelioma (MM) is high. The use of BAP1/MTAP immunohistochemistry (IHC) is…
Read MoreMalignant Pleural Mesothelioma: Genetic and Microenviromental Heterogeneity as an Unexpected Reading Frame and Therapeutic Challenge
Cancers 2020 May 7 [Link] David Michael Abbott, Chandra Bortolotto, Silvia Benvenuti, Andrea Lancia, Andrea Riccardo Filippi, Giulia Maria Stella Abstract Mesothelioma is a malignancy of serosal membranes including the peritoneum, pleura, pericardium and the tunica vaginalis of the testes. Malignant mesothelioma (MM) is a rare disease with a global incidence in countries like Italy…
Read MoreTumour cell PD-L1 expression is prognostic in patients with malignant pleural effusion: the impact of C-reactive protein and immune-checkpoint inhibition.
Scientific Reports 2020 April 1 [Link] Ghanim B, Rosenmayr A, Stockhammer P, Vogl M, Celik A, Bas A, Kurul IC, Akyurek N, Varga A, Plönes T, Bankfalvi A, Hager T, Schuler M, Hackner K, Errhalt P, Scheed A, Seebacher G, Hegedus B, Stubenberger E, Aigner C Abstract Malignant pleural effusion (MPE) confers dismal prognosis and…
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