Symptoms & Symptom Management
Contribution of BAP1 loss and p16 (CDKN2A) deletion analysis to the definitive diagnosis of mesothelioma in effusion cytology
European Review for Medical and Pharmacological Sciences 2023 October [Link] G Aydogdu, S Özekinci Abstract Objective: The cytological diagnosis of mesothelioma is a controversial issue, and definitive diagnosis often requires ancillary tests. The aim of this study was to investigate the contribution of BRCA1-associated protein (1) (BAP1) loss and p16 (CDKN2A) homozygous deletion (HD) on…
Read MoreMTH1 Inhibition Alleviates Immune Suppression and Enhances the Efficacy of Anti-PD-L1 Immunotherapy in Experimental Mesothelioma
Cancers 2023 October 12 [Link] Sophia F Magkouta, Photene C Vaitsi, Marianthi P Iliopoulou, Apostolos G Pappas, Chrysavgi N Kosti, Katherina Psarra, Ioannis T Kalomenidis Abstract Background: MTH1 protects tumor cells and their supporting endothelium from lethal DNA damage triggered by oxidative stress in the tumor microenvironment, thus promoting tumor growth. The impact of MTH1…
Read MoreClaudin-4 immunocytochemistry is specific and sensitive for the diagnosis of malignant carcinomatous effusions: Results from a pilot study
Diagnostic Cytopathology 2023 October 13 [Link] Vanlal Hruaii, Balamurugan Thirunavukkarasu, Vindhya Prabha, Sandeep Mathur, Venkateswaran K Iyer, Aruna Nambirajan, Deepali Jain Abstract Background: Claudin-4, a tight junction associated protein expressed in epithelial cells, is purported as a highly specific and sensitive marker for epithelial malignancies. Our aim was to assess the sensitivity, specificity and real-time…
Read MoreGelatinous Pleural Effusion: A Diagnostic Challenge for Pleural Mesothelioma in an 80-Year-Old Man
American Journal of Case Reports 2023 October 4 [Link] Ali M Ibnian, Obaid Ullah Khan, Richard Chan, Umesh Bangalore Lakshminarayana, Fasiha Kiran, Sarah Abed, Rahim Abbas, Ahsan Amir, Noran K Al-Kofahi Abstract BACKGROUND Gelatinous pleural effusion, due to raised hyaluronic acid, can be associated with pleural infection and malignancies, such as tuberculosis, metastatic pleural disease,…
Read MoreMalignant mesothelioma cells with characteristic intracytoplasmic vacuolization and lipids
Diagnostic Cytopathology 2023 August 15 [Link] Satoshi Morito, Hiroshi Yasui, Tomoo Itoh, Shingo Kamoshida, Hiroyuki Ohsaki Abstract In this brief report, we described some uncommon cytomorphological features of malignant mesothelioma (MM) cells in pleural effusions. The tumor cells exhibited abundant cytoplasmic vacuolization, with presence of single or multiple eccentric nuclei in several cells. In the…
Read MoreMalignant Pleural Mesothelioma (MPM) Presenting as Hydropneumothorax
Cureus 2023 July 1 [Link] Masami Kuramochi, Takuma Muraoka, Mayumi Shinonaga, Haruo Ohtani, Setsuo Kuraoka Abstract An 86-year-old man presented with bilateral lower limb edema and was found to have hydropneumothorax on chest radiography. CT revealed a substantial pleural effusion and plaques. The patient had a history of working in a stone workshop, but the…
Read MoreA rare presentation of malignant mesothelioma of the tunica vaginalis managed with immunotherapy and review of the literature
Clinical Case Reports 2023 June 22 [Link] Kritika Mishra, Shihab Siddiquee, Anna Rachelle Mislang Abstract Key clinical message: We describe the first case in literature of malignant mesothelioma of the tunica vaginalis that has shown partial response to systemic immunotherapy (ipilimumab-nivolumab) post orchiectomy, warranting further investigation in a trial setting. Abstract: We present a case…
Read MoreComparison of immunohistochemical mesothelial biomarkers in paired biopsies and effusion cytology cell blocks from pleural mesothelioma
Cytopathology 2023 June 19 [Link] Mohammed S I Mansour, Adela Huseinzade, Tomas Seidal, Kim Hejny, Athar Maty, Fereshteh Taheri-Eilagh, Ulrich Mager, Annika Dejmek, Katalin Dobra, Hans Brunnström Abstract Objective: Traditionally, the diagnosis of pleural mesothelioma is based on histological material. Minimally invasive effusion cytology specimens are an alternative that, like biopsies, require ancillary analyses. Validation…
Read MoreIntrapleural Anticancer Therapy for Malignant Pleural Diseases: Facts or Fiction?
Seminars in Respiratory Critical Care Medicine 2023 August [Link] Abhinav Agrawal, Udit Chaddha, Samira Shojaee, Fabien Maldonado Abstract Malignant pleural diseases involves both primary pleural malignancies (e.g., mesothelioma) as well as metastatic disease involving the pleura. The management of primary pleural malignancies remains a challenge, given their limited response to conventional treatments such as surgery,…
Read MoreHigh Expression of SMO and GLI1 Genes with Poor Prognosis in Malignant Mesothelioma
Biomed Research International 2023 April 24 [Link] Guan-Ying Ma, Shuai Shi, Yin-Zhou Sang, Ping Wang, Zhi-Gang Zhang Abstract Background: To investigate the value of SMO and GLI1 genes in the hedgehog pathway in malignant mesothelioma specimens. Further study on the expression and prognosis of SMO and GLI1 in malignant mesothelioma tissues and the relationship between…
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