Symptoms & Symptom Management
Potential utility of miRNAs derived from pleural fluid extracellular vesicles to differentiate between benign and malignant pleural effusions
Translational Lung Cancer Research 2025 January 24 [Link] Tian Mun Chee, Caeli J Zahra, Kwun M Fong, Ian A Yang, Rayleen V Bowman Abstract Background: Cytological examination is of suboptimal sensitivity but high specificity for the diagnosis of malignant pleural effusions (MPEs). Pleural fluid extracellular vesicles (PFEVs) are enriched with disease-specific microRNAs (miRNAs) which may…
Read MoreAmerican Association of Bronchology and Interventional Pulmonology Essential Knowledge in Interventional Pulmonology Series: Selected Topics in Malignant Pleural Disease
Journal of Bronchology and Interventional Pulmonology 2024 December 20 [Link] Ara A Chrissian, Hatoon Abbas, Udit Chaddha, Labib G Debiane, Erin DeBiasi, Darius Filsoof, Muhammad Daniyal Hashmi, Christopher Morton, Warren C Naselsky, Jasleen Pannu, Reza Ronaghi, Bertin D Salguero, Cristina Salmon, Shelby J Stewart, Colleen L Channick Abstract The goal of the American Association of…
Read MoreRole of Immunocytochemistry in the Cytological Diagnosis of Mesothelioma
Acta Cytologica 2024 December 12 [Link] Claire W Michael, Shannon Alexandra Rodgers Abstract Background: Mesothelioma is an aggressive malignancy of the serosal surfaces with very poor prognosis. It traditionally manifests in older patients and at an advanced stage which results in minimal improvement in prognosis despite the recent advances in management. Early detection would therefore…
Read MoreDiffuse Pleural Mesothelioma: A Challenge in Early Diagnosis
Cureus 2024 December 2 [Link] Ancuta-Alina Constantin, Florin Dumitru Mihaltan, Angela-Stefania Marghescu, Gabriela Andreea Craciunica Abstract We present the clinical case of a 58-year-old female patient, a smoker with occupational exposure to respiratory toxins, who was admitted to our clinic following evaluation in an emergency department, where she was diagnosed with a moderate right pleural…
Read MoreEffects of patient pleural effusion fluids on the BBSome components expression of human benign mesothelial cells
American Journal of Physiology, Lung Cellular, and Molecular Physiology 2025 January 1 [Link] Rajesh M Jagirdar, Erasmia Rouka, Eleanna Pitaraki, Ioannis Sarrigeorgiou, Ourania S Kotsiou, Sotiris I Sinis, Eleftherios D Papazoglou, Periklis Marnas, Zoi Malami, Peggy Lymberi, Anastasios D Giannou, Chrissi Hatzoglou, Konstantinos I Gourgoulianis, Sotirios G Zarogiannis Abstract Malignant pleural mesothelial cells are affected…
Read MoreStem-like exhausted CD8 T cells in pleural effusions predict improved survival in non-small cell lung cancer (NSCLC) and mesothelioma
Translational Lung Cancer Research 2024 September 30 [Link] Linda Ye, Heeju Ryu, David Granadier, Long T Nguyen, Yannick Simoni, Ian Dick, Tina Firth, Ebony Rouse, Peter Chiang, Y C Gary Lee, Bruce W Robinson, Jenette Creaney, Evan W Newell, Alec J Redwood Abstract Background: Anti-tumor CD8 T cells are important for immunity but can become…
Read MoreDeterminants of Mortality Among US Patients Diagnosed With Malignant Pleural Mesothelioma Over the Past Decade
Journal of Community Hospital Internal Medicine Perspectives 2024 September 9 [Link] Ayrton Bangolo, Pierre Fwelo, Amer Jarri, Sai P Pulipaka, Vignesh K Nagesh, Nikita Wadhwani, Budoor Alqinai, Sidra Sohail, Geetha Keshav, Angel A Chacko, Aiswarya Menon, Luis Periel, Zuhair S Siddiqui, Bibek Pyakurel, Sandra Kunnel, Matthew Maturasingh, Gillan Quirequire, Jerusha Gudapati, Ashfi Hoque, Zubair Habib,…
Read MoreChallenging the Norm: Occurrence of Synchronous Pleural and Peritoneal Mesothelioma in a Female Patient
Cureus 2024 August 18 [Link] Surendar Reddy, Kavya M G, Rakesh Gattu, Alekya P, Manasa Kuthadi Abstract Here, we present a unique case involving a female patient in her 40s with synchronous malignant pleural and peritoneal mesothelioma, despite lacking a history of asbestos exposure. The patient’s initial symptoms included dyspnoea, chest pain, cough, fever, appetite…
Read MoreCombined detection of SHOX2 and PTGER4 methylation with serum marker CYFRA21-1 for improved diagnosis of malignant pleural mesothelioma
Journal of Clinical Pathology 2024 July 26 [Link] Nana Zhang, Yongmeng Li, Zuyu Sun, Yujie Dong, Lijuan Zhou, Chen Zhang, Zichen Liu, Qiuyi Zhang, Kun Li, Fudong Xu, Li Zhang, Bin She, Xiaosha Ren, Nanying Che Abstract Aims: To investigate the performance of a combined biomarker approach using the methylation status of the short stature…
Read MoreLeucine rich α2 glycoprotein 1 derived from malignant pleural mesothelioma cells facilitates macrophage M2 phenotypes
Experimental Lung Research 2024 [Link] Dandan Wang, Wenjing Pei, Yanfei Liu, Rongliang Mo, Xinru Li, Wenhui Gu, Yi Su, Jing Ye, Jiegou Xu, Dahai Zhao Abstract Background: Macrophages constitute the main part of infiltrating immune cells in Malignant pleural mesothelioma (MPM) and abnormally high ratios of M2 macrophages are present in both pleural effusion and…
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