Symptoms & Symptom Management
A Rare Case of Pleural Epithelioid Mesothelioma With a Prominent Myxoid Stroma Reported With Morphology, Fluorescent In Situ Hybridization, and Ultrastructural Findings
Cureus 2024 June 12 [Link] Hiroshi Sonobe, Rika Omote, Toshiyuki Habara, Kazuhiro Washio, Nobuyoshi Yamazoe, Shinji Matsumoto, Kazuki Nabeshima, Hiroko Toda Abstract Herein, we report a rare case of pleural epithelioid malignant mesothelioma with a prominent myxoid stroma. To date, detailed morphological or molecular pathological findings have not been reported for this type of tumor.…
Read MoreCharacterizing soluble immune checkpoint molecules and TGF-β1,2,3 in pleural effusion of malignant pleural mesothelioma
Scientific Reports 2024 July 10 [Link] Riki Okita, Tomoya Senoo, Yuka Mimura-Kimura, Yusuke Mimura, Tomoyuki Murakami, Eiji Ikeda, Masanori Okada, Hidetoshi Inokawa, Keisuke Aoe Abstract The clinical impact of soluble molecules in pleural effusion (PE) is unclear in patients with malignant pleural mesothelioma (MPM). In this single-center, retrospective, observational study, we assessed soluble forms of…
Read MoreA rare case of a huge malignant pleural mesothelioma presenting in the posterior mediastinum
Respirology Case Reports 2024 July 9 [Link] Yuta Mori, Chihiro Kato, Hideo Yamakawa, Mariko Sugiura, Kensuke Fukumitsu, Satoshi Fukuda, Yoshihiro Kanemitsu, Takehiro Uemura, Tomoko Tajiri, Hirotsugu Ohkubo, Yutaka Ito, Tetsuya Oguri, Takayuki Murase, Akio Niimi Abstract We report a case of a 69-year-old woman with pleural mesothelioma presenting in the posterior mediastinum with a maximum…
Read MoreReview on treatment of pleural metastasis and malignant pleural effusion with Pressurized IntraThoracic Aerosol Chemotherapy (PITAC)
Pleura and Peritoneum 2024 May 17 [Link] Pernille Schjødt Hansen, Martin Graversen, Sönke Detlefsen, Michael Bau Mortensen Abstract Background: Malignant pleural effusion (MPE) is a common and debilitating condition seen in advanced cancer disease, and life-expectancy is short. Symptoms include pain and severe shortness of breath. Current first-line treatment options include pleural drainage using catheters…
Read MoreOptimal isolation of extracellular vesicles from pleural fluid and profiling of their microRNA cargo
Journal of Extracellular Biology 2023 October 16 [Link] Tian Mun Chee, Hannah E O’Farrell, Luize G Lima, Andreas Möller, Kwun M Fong, Ian A Yang, Rayleen V Bowman Abstract Pleural effusion occurs in both benign and malignant pleural disease. In malignant pleural effusions, the diagnostic accuracy and sensitivity of pleural fluid cytology is less than…
Read MoreLeveraging the pleural space for anticancer therapies in pleural mesothelioma
The Lancet Respiratory Medicine 2024 May 10 [Link] Kevin G Blyth, Prasad S Adusumilli, Philippe Astoul, Liz Darlison, Y C Gary Lee, Aaron S Mansfield, Stefan J Marciniak, Nick Maskell, Vasiliki Panou, Tobias Peikert, Najib M Rahman, Marjorie G Zauderer, Daniel Sterman, Dean A Fennell Abstract Most patients with pleural mesothelioma (PM) present with symptomatic…
Read MoreEstablishing mesothelioma patient-derived organoid models from malignant pleural effusions
Lung Cancer 2024 March 28 [Link] Ashleigh J Hocking, Lauren A Mortimer, Alexandra L Farrall, Prudence A Russell, Sonja Klebe Abstract Objectives: Pleural mesothelioma is a cancer arising in the cells that line the lungs and chest wall with poor survival and poor response to first-line therapy. Organoid models of cancer can faithfully recapitulate the…
Read MoreImmune modulation in malignant pleural effusion: from microenvironment to therapeutic implications
Cancer Cell International 2024 March 12 [Link] Shan Ge, Yuwei Zhao, Jun Liang, Zhongning He, Kai Li, Guanghui Zhang, Baojin Hua, Honggang Zheng, Qiujun Guo 2, Runzhi Qi, Zhan Shi Abstract Immune microenvironment and immunotherapy have become the focus and frontier of tumor research, and the immune checkpoint inhibitors has provided novel strategies for tumor…
Read MoreSuccessful treatment of simultaneous malignant pleural mesothelioma and pulmonary adenocarcinoma: A case report
Oncology Letters 2024 February 15 [Link] Yuki Amakusa, Tatsuro Suzuki, Yu Hikosaka, Masaya Takemura, Tetsuya Oguri Abstract The present report described the case of a 74-year-old male patient with asbestos exposure whose chest computed tomography revealed a right lower lobe nodule and right pleural effusion. Pleural biopsy led to the diagnosis of epithelial malignant pleural…
Read MoreDetailed clinical course of a patient with rapidly progressing sarcomatoid pleural mesothelioma without p16 deletion with systemic haematogenous metastasis to soft tissues
BMJ Case Reports 2024 February 10 [Link] Keiichi Mizuhashi, Kenzo Okamoto, Kazuki Nabeshima, Takumi Kishimoto Abstract Sarcomatoid mesothelioma is difficult to differentiate from other mesotheliomas. Here, we describe the case of a man in his early 80s with sarcomatoid mesothelioma and a history of asbestos exposure. He initially presented with right-sided chest pain and was…
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