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Mesothelioma-Line

Curated Journal Articles on Mesothelioma

Category Archives: Pleural

Malignant pleural mesothelioma; mesothelioma of the lining of the lungs, or pleura.

Should Lung-Sparing Surgery Be the Standard Procedure for Malignant Pleural Mesothelioma?

Journal of Clinical Medicine 2020 July 8 [Link] Yoshinobu Ichiki, Hidenori Goto, Takashi Fukuyama, Kozo Nakanishi Abstract Background: Surgical procedures for malignant pleural mesothelioma (MPM) include extrapleural pneumonectomy (EPP), extended pleurectomy/decortication (P/D) and P/D. EPP has been applied to MPM for a long time, but the postoperative status is extremely poor due to the loss […]

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Histologically Diverse BAP1-Deficient Melanocytic Tumors in a Patient With BAP1 Tumor Predisposition Syndrome

The American Journal of Dermatopathology 2020 July 7 [Link] Amber Louw, Jenette Creaney, Anitha Thomas, Chris Van Vliet, Nathan Tobias Harvey, Benjamin Andrew Wood, Nima Mesbah Ardakani Abstract BRCA1-associated protein-1 (BAP1)-deficient cutaneous tumors are common in patients with BAP1 tumor predisposition syndrome, frequently presenting before other associated neoplasms, and can serve as an early marker […]

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Acute kidney injury after cytoreductive surgery and hyperthermic intraoperative cisplatin chemotherapy for malignant pleural mesothelioma

The Journal of Thoracic and Cardiovascular Surgery 2020 May 29 [Link] Tammy Hod, Katherin J Freedberg, Shveta S Motwani, Margaret Chen, Gyorgy Frendl, David E Leaf, Shruti Gupta, Suraj Sarvode Mothi, William G Richards, Raphael Bueno, Sushrut S Waikar Abstract Objectives: Cytoreductive surgery with hyperthermic intraoperative chemotherapy with cisplatin has been used successfully to treat […]

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Clinical Features in Patients With Malignant Pleural Mesothelioma With 5-Year Survival and Evaluation of Original Diagnoses

Clinical Lung Cancer 2020 May 23 [Link] Juuso Paajanen, Sanna Laaksonen, Ilkka Ilonen, Tapio Vehmas, Mikko I Mäyränpää, Eva Sutinen, Eeva Kettunen, Jarmo A Salo, Jari Räsänen, Henrik Wolff, Marjukka Myllärniemi Abstract Introduction: Malignant pleural mesothelioma (MPM) is a fatal malignancy strongly associated with previous asbestos exposure. Overall survival remains dismal, partly owing to poor […]

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Quantitative 99m Tc Labeling Kit for HYNIC-Conjugated Single Chain Antibody Fragments Targeting Malignant Mesothelioma

Bioconjugate Chemistry 2020 July 15 [Link] Jiang He, Jinjin Feng, Yang Su, Youngho Seo, Bin Liu Abstract Single chain antibody fragment (scFv) is a promising agent for imaging and targeted therapy. The objective of the study is to evaluate a kit formulation for 99mTc labeling of scFv for tumor imaging. The scFv was engineered to […]

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TLD1433-Mediated Photodynamic Therapy with an Optical Surface Applicator in the Treatment of Lung Cancer Cells In Vitro

Pharmaceuticals 2020 June 28 [Link] Sarah Chamberlain, Houston D Cole, John Roque 3rd, David Bellnier, Sherri A McFarland, Gal Shafirstein Abstract Intra-operative photodynamic therapy (IO-PDT) in combination with surgery for the treatment of non-small cell lung cancer and malignant pleural mesothelioma has shown promise in improving overall survival in patients. Here, we developed a PDT […]

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A Phase II Trial of Alisertib (MLN8237) in Salvage Malignant Mesothelioma

The Oncologist 2020 July 1 [Link] Carl M Gay, Yanhong Zhou, J Jack Lee, Xi Ming Tang, Wei Lu, Ignacio I Wistuba, Renata Ferrarotto, Don L Gibbons, Bonnie S Glisson, Merrill S Kies, George R Simon, John V Heymach, Anne S Tsao Abstract Lessons learned: Treatment with the Aurora kinase A inhibitor yields often durable […]

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Lamellar Inclusions within Hyperplastic Endoplasmic Reticulum in Benign Mesothelial Cells

Acta Cytologica 2020 June 29 [Link] Simon Haefliger, Deepali Jain, Thomas Menter, Tatjana Vlajnic, Spasenija Savic Prince, Helmut Hopfer, Michael J Mihatsch, Lukas Bubendorf Abstract Introduction: In effusion cytology, mesothelial cells can occasionally present with striking intracytoplasmic accumulation of rod- and crystal-like cytoplasmic lamellar inclusions (LIs). Their nature and function are poorly understood, and their […]

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Acquired multiple mutations ALK I1171N, L1196M and G1202R mediate lorlatinib resistance in EML4-ALK-rearranged malignant pleural mesothelioma: a case report

Therapeutic Advances in Respiratory Disease Jan-Dec 2020 [Link] Jia Hu, Baoshi Zhang, Fangfang Yao, Yan Fu, Dianjun Chen, Donghui Li, Nan Du, Analyn Lizaso, Jinlei Song, Lu Zhang, Xiaosong Li Abstract EML4-ALK rearranged malignant pleural mesothelioma (MPM) is rare and its responses to anaplastic lymphoma kinase (ALK) inhibitors, including alectinib and lorlatinib, remain unexplored. In […]

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Questioning the Prognostic Role of BAP-1 Immunohistochemistry in Malignant Pleural Mesothelioma: A Single Center Experience With Systematic Review and Meta-Analysis

Lung Cancer 2020 June 21 [Link] Luca Cantini, Federica Pecci, Alberto Murrone, Marco Tomasetti, Cecilia Copparoni, Ilaria Fiordoliva, Francesca Morgese, Silvia Rinaldi, Paola Mazzanti, Corrado Rubini, Alessia Cimadamore, Francesca Barbisan, Riccardo Giampieri, Marina Scarpelli, Lory Santarelli, Rossana Berardi Abstract Introduction: The prognostic role of BRCA1 associated protein-1 (BAP1) expression in malignant pleural mesothelioma (MPM) is […]

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