Unleashing precision: A review of targeted approaches in pleural mesothelioma

August 28, 2024

Critical Reviews in Oncology and Hematology 2024 August 17 [Link] Mario Occhipinti, Marta Brambilla, Raimondo Di Liello, Paolo Ambrosini, Lorenzo Lobianco, Rita Leporati, Maria Salvarezza, Fabiana Vitiello, Silvia Marchesi, Sara Manglaviti, Teresa Beninato, Laura Mazzeo, Claudia Proto, Arsela Prelaj, Roberto Ferrara, Carminia Maria Della Corte, Giuseppe Lo Russo, Filippo de Braud, Monica Ganzinelli, Giuseppe Viscardi…

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Volatile Organic Compound Analysis of Malignant Pleural Mesothelioma Chorioallantoic Membrane Xenografts

August 26, 2024

Journal of Breath Research 2024 August 20 [Link] Liam David Little, Sarah E Barnett, Theo Issitt, Sam Bonsall, Vikki Amanda Carolan, K Elizabeth Allen, Laura Margaret Cole, Neil A Cross, Judy M Coulson, Sarah Louise Haywood-Small Abstract Malignant pleural mesothelioma (MPM) is an aggressive cancer associated with asbestos exposure. MPM is often diagnosed late, at…

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Pleural fluid biomarkers: a narrative review

August 21, 2024

Journal of Thoracic Disease 2024 July 30 [Link] Christopher Chan, Ken Ka Pang Chan Abstract Background and objective: Pleural fluid is a source from which various biomarkers can be obtained and measured to facilitate the management and prognostication of various conditions. This narrative review aims to summarise a few selected applications of pleural fluid biomarker…

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Outcome prediction based on [18F]FDG PET/CT in patients with pleural mesothelioma treated with ipilimumab and nivolumab +/- UV1 telomerase vaccine

August 20, 2024

European Journal of Nuclear Medicine and Molecular Imaging 2024 August 12 [Link] Solfrid Thunold, Eivor Hernes, Saima Farooqi, Åsa Kristina Öjlert, Roslyn J Francis, Anna K Nowak, Weronika Maria Szejniuk, Søren Steen Nielsen, Susana Cedres, Marc Simo Perdigo, Jens Benn Sørensen, Carin Meltzer, Lars Tore Gyland Mikalsen, Åslaug Helland, Eirik Malinen, Vilde Drageset Haakensen Abstract…

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Peritoneal Dissemination in Patients with Recurrence After Post-pleurectomy/decortication for Pleural Mesothelioma

August 19, 2024

Annals of Surgical Oncology 2024 August 10 [Link] Akifumi Nakamura, Masaki Hashimoto, Ayumi Kuroda, Kyoshiro Takegahara, Akihiro Fukuda, Seiji Matsumoto, Nobuyuki Kondo, Toshiyuki Minami, Kazuhiro Kitajima, Kozo Kuribayashi, Takashi Kijima, Soichiro Funaki, Seiki Hasegawa Abstract Background: In clinical practice, peritoneal dissemination after curative-intent surgery for pleural mesothelioma occasionally recurs. This study investigated the risk factors…

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Comparison of First-Line Chemotherapeutics and Validation of the EORTC Prognostic Index in Malignant Pleural Mesothelioma: Retrospective Single-Centre Experience

August 16, 2024

Journal of the College of Physicians and Surgeons 2024 August [Link] Yasin Sezgin, Ogur Karhan, Serdar Ileri, Senar Ebinc, Sezai Tunc, Zuhat Urakci Abstract Objective: To evaluate the efficiency of pemetrexed cisplatin in comparison with gemcitabine cisplatin and to validate the EORTC (European Organisation for Research and Treatment of Cancer) prognostic score in combination chemotherapy…

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Patient characteristics, treatment patterns, and survival outcomes for patients with malignant pleural mesothelioma in Denmark between 2011 and 2018: a nationwide population-based cohort study

August 15, 2024

Acta Oncologica 2024 August 8 [Link] Jens Benn Sørensen, Paul Baas, Szimonetta Komjáthiné Szépligeti, Alma B Pedersen, Søren P Johnsen, Robert Carroll, Minouk J Schoemaker, Caroline Rault, Melinda J Daumont, Vera Ehrenstein Abstract Background: Malignant pleural mesothelioma (MPM) is a rare thoracic malignancy with poor prognosis and limited treatment options. Immunotherapy shows potential for improved…

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Enhancing the immunogenicity of Wilms tumor 1 epitope in mesothelioma cells with immunoproteasome inhibitors

August 14, 2024

PLoS One 2024 August 8 [Link] Masaki Ito, Shigeo Koido, Takeo Iwamoto, Soyoko Morimoto, Fumihiro Fujiki, Haruo Sugiyama, Saki Matsumoto, Clara Effenberger, Kazuma Kiyotani, Kiyotaka Shiba Abstract The immunogenicity of cancer cells is influenced by several factors, including the expression of the major histocompatibility complex class I (MHC-I), antigen expression, and the repertoire of proteasome-produced…

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Major response of a peritoneal mesothelioma to nivolumab and ipilimumab: a case report, molecular analysis and review of literature

August 8, 2024

Frontiers in Oncology 2024 July 18 [Link] Marie-Florence Reveneau, Julien Masliah-Planchon, Manuel Fernandez, Abdenour Ouikene, Bernard Dron, Innocenti Dadamessi, Charles Dayen, Lisa Golmard, Bruno Chauffert Abstract Malignant peritoneal mesothelioma (MPM) is a rare tumor associated with a poor prognosis and a lack of consensus regarding treatment strategies. While the Checkmate 743 trial demonstrated the superiority…

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