Pleural
Journey to the centre of the lung. The perspective of a mineralogist on the carcinogenic effects of mineral fibres in the lungs
Journal of Hazardous Materials 2023 January 15 [Link] Alessandro F Gualtieri Abstract This work reviews the bio-chemical mechanisms leading to adverse effects produced when mineral fibres are inhaled and transported in the lungs from the perspective of a mineralogist. The behaviour of three known carcinogenic mineral fibres (crocidolite, chrysotile, and fibrous-asbestiform erionite) during their journey…
Read MoreEmerging Role of Immunomonitoring to Predict the Clinical Outcome of Patients With Malignant Pleural Mesothelioma Treated With Radical Radiation Therapy
International Journal of Radiation Oncology, Biology, Physics 2022 October 3 [Link] Michela Cangemi, Marcella Montico, Marco Trovo, Emilio Minatel, Emanuela Di Gregorio, Giuseppe Corona, Fabiana Giordari, Elisa Comaro, Francesca Colizzi, Lorena Baboçi, Agostino Steffan, Alberto Revelant, Elena Muraro Abstract Purpose: The present study aimed at evaluating the baseline immune profile and the immunomodulating effects of…
Read MoreFactors affecting the life expectancy in malignant pleural mesothelioma: Our 10 years of studies and experience
Medicine 2022 September 30 [Link] Filiz Cimen, Yetkin Agackiran, Sevim Düzgün, Melike Aloglu, Aysegül Senturk, Sükran Atikcan Abstract Malignant pleural mesothelioma (MPM) is an aggressive tumor with a poor prognosis. In our study, we aimed to investigate the specific clinical, laboratory, and radiological features of the tumor and the prognostic effect of SUVmax (maximum standardized…
Read MoreButein-instigated miR-186-5p-dependent modulation of TWIST1 affects resistance to cisplatin and bioenergetics of Malignant Pleural Mesothelioma cells
Cancer Drug Resistance 2022 July 3 [Link] Mario Cioce, Daniela Rutigliano, Annamaria Puglielli, Vito Michele Fazio Abstract Aim: Malignant pleural mesothelioma is a chemoresistant tumor, and biphasic and sarcomatoid histologies portend the worst prognosis for malignant pleural mesothelioma (MPM) patients. We obtained the microRNA expression profile of three biphasic-sarcomatoid MPM cell lines to identify commonly…
Read MoreInvestigation of pd-l1 (cd274), pd-l2 (pdcd1lg2), and ctla-4 expressions in malignant pleural mesothelioma by immunohistochemistry and real-time polymerase chain reaction methods
Polish Journal of Pathology 2022 October 6 [Link] Fatma Sule Kutlar Dursun, Ulas Alabalik Abstract Introduction: Malignant pleural mesothelioma (MPM) is an aggressive malignant disease with a poor prognosis, which affects the surface mesothelium of the pleural cavity. Immune checkpoints are responsible for controlling the immune system to avoid autoimmunity and prevent tissue damage. In…
Read MoreImmunotherapy combined with antiangiogenic agents in patients with advanced malignant pleural mesothelioma: A case report
World Journal of Clinical Cases 2022 August 16 [Link] Tian-Tian Xuan, Guang-Yi Li, Si-Bo Meng, Zhan-Mei Wang, Lin-Li Qu Abstract Background: Malignant pleural mesothelioma has limited therapeutic options and a poor outcome. Antiangiogenic agents might increase the efficacy of immunotherapy as second-line treatment of advanced-stage malignancies. Case summary: A patient with stage IIIB pleural mesothelioma…
Read MoreDefine the Two Molecular Subtypes of Epithelioid Malignant Pleural Mesothelioma
Cells 2022 September 19 [Link] Umair Ali Khan Saddozai, Fengling Wang, Saadullah Khattak, Muhammad Usman Akbar, Muhammad Badar, Nazeer Hussain Khan, Lu Zhang, Wan Zhu, Longxiang Xie, Yongqiang Li, Xinying Ji, Xiangqian Guo Abstract Malignant pleural mesothelioma (MPM) is a fatal disease of respiratory system. Despite the availability of invasive biomarkers with promising results, there…
Read MoreIncidence and Risk Factors of Chest Wall Metastasis at Biopsy Sites in Patients with Malignant Pleural Mesothelioma
Cancers 2022 September 7 [Link] Masaki Hashimoto, Michiko Yuki, Kazuhiro Kitajima, Akihiro Fukuda, Toru Nakamichi, Akifumi Nakamura, Ayumi Kuroda, Seiji Matsumoto, Nobuyuki Kondo, Ayuko Sato, Koichiro Yamakado, Tohru Tsujimura, Seiki Hasegawa Abstract To investigate the incidence and risk factors of chest wall metastasis (CWM) at biopsy sites in patients with malignant pleural mesothelioma (MPM). This…
Read MoreSystematic Review, Meta-Analysis and Bioinformatic Analysis of Biomarkers for Prognosis of Malignant Pleural Mesothelioma
Diagnostics 2022 September 12 [Link] Zhenhua Lu, Wenlong Zhang, Ke Huang, Mucheng Zhu, Xiaoting Gu, Defang Wei, Mingxuan Shi, Yaqiong Chen , Huihui Wang Abstract In previous studies, non-invasive diagnostic biomarkers showed great benefit in the early-stage diagnosis of malignant pleural mesothelioma (MPM). However, the accuracy of different biomarkers was controversial. In this study, meta-analysis…
Read MoreCytoreductive Surgical Treatment of Pleural Mesothelioma in a Porcine Model Using Magnetic-Resonance-Guided Focused Ultrasound Surgery (MRgFUS) and Radiofrequency Ablation (RFA)
Tomography 2022 September 3 [Link] Marcia Costa, Carolina Fernandes, Matt Eames, Arik Hananel , John P Mugler 3rd, Jhosep Huaromo, Jack B Yang, Jaime Mata Abstract A combination of surgery and chemotherapy is the most effective treatment available for Malignant Pleural Mesothelioma (MPM). However, both cause significant collateral damage and cannot eliminate residual microscopic disease.…
Read More