Pleural
Outcomes of Conversion to Extrapleural Pneumonectomy from Pleurectomy/Decortication for Malignant Pleural Mesothelioma
Seminars in Thoracic and Cardiovascular Surgery 2021 February 17 [Link] Akifumi Nakamura, Masaki Hashimoto, Seiji Matsumoto, Nobuyuki Kondo, Takashi Kijima, Seiki Hasegawa Abstract In recent years, there has been a shift from extrapleural pneumonectomy (EPP) toward pleurectomy/decortication (P/D) as the preferred surgical technique. However, we occasionally encounter difficult cases wherein visceral pleurectomy requires conversion to…
Read MoreGATA3 is a useful immunohistochemical marker for distinguishing sarcomatoid malignant mesothelioma from lung sarcomatoid carcinoma and organizing pleuritis
Virchows Archiv 2021 February 11 [Link] Zheng Hua Piao, Xin Cheng Zhou, Jia Yi Chen Abstract Sarcomatoid malignant mesothelioma (SMM) tends to occur in the pleura and is morphologically similar to lung sarcomatoid carcinoma (LSC) and organizing pleuritis (OP). Because SMM often does not express mesothelial markers, it is very difficult to distinguish from LSC…
Read MoreEnhanced anti-tumor efficacy of IL-7/CCL19-producing human CAR-T cells in orthotopic and patient-derived xenograft tumor models
Cancer Immunology, Immunotherapy 2021 February 8 [Link] Shunsuke Goto, Yukimi Sakoda, Keishi Adachi, Yoshitaka Sekido, Seiji Yano, Masatoshi Eto, Koji Tamada Abstract Chimeric antigen receptor (CAR)-T cell therapy has impressive efficacy in hematological malignancies, but its application in solid tumors remains a challenge. Multiple hurdles associated with the biological and immunological features of solid tumors…
Read MoreSerum soluble mesothelin-related protein (SMRP) and fibulin-3 levels correlate with baseline malignant pleural mesothelioma (MPM) tumor volumes but are not useful as biomarkers of response in an immunotherapy trial
Lung Cancer 2021 January 14 [Link] Sharyn I Katz, Leonid Roshkovan, Ian Berger, Joseph S Friedberg, Evan W Alley, Charles B Simone 2nd, Andrew R Haas, Keith A Cengel, Daniel H Sterman, Steven M Albelda Abstract Objectives: Soluble mesothelin-related protein (SMRP) and fibulin-3 serum levels may serve as diagnostic and prognostic biomarkers of malignant pleural…
Read MorePotential role of serum mesothelin in predicting survival of patients with malignant pleural mesothelioma
Oncology Letters 2021 February [Link] Vincenzo Fontana, Maria Pia Pistillo, Antonella Vigani, Pier Aldo Canessa, Giovanni Berisso, Ugo Giannoni, Paola Ferro, Maria Cristiana Franceschini, Roberta Carosio, Marika Tonarelli, Paolo Dessanti, Silvio Roncella Abstract Malignant pleural mesothelioma (MPM) is an aggressive tumor with poor survival rates. Therefore, it is essential to have effective biological markers predicting…
Read MoreAlterations in BAP1 are Associated with Cisplatin Resistance Through Inhibition of Apoptosis in Malignant Pleural Mesothelioma (MPM)
Clinical Cancer Research 2021 February 5 [Link] Kathrin Oehl, Bart Vrugt, Ulrich Wagner, Michaela B Kirschner, Mayura Meerang, Walter Weder, Emanuela Felley-Bosco, Bernd Wollscheid, Katrin Bankov, Melanie C Demes, Isabelle Opitz, Peter J Wild Abstract Purpose: The clinical standard treatment for patients with malignant pleural mesothelioma (MPM) includes a cisplatin-based chemotherapy, leading to reduction of…
Read MoreThe role of polymorphisms in glutathione-related genes in asbestos-related diseases
Radiology and Oncology 2021 January 26 [Link] Alenka Franko, Katja Goricar, Metoda Dodic Fikfak, Viljem Kovac, Vita Dolzan Abstract Background: The study investigated the influence of GCLC, GCLM, GSTM1, GSTT1 and GSTP1 polymorphisms, as well as the influence of interactions between polymorphism and interactions between polymorphisms and asbestos exposure, on the risk of developing pleural…
Read MoreImpact of CT convolution kernel on robustness of radiomic features for different lung diseases and tissue types
The British Journal of Radiology 2021 February 5 [Link] Sarah Denzler, Diem Vuong, Marta Bogowicz, Matea Pavic, Thomas Frauenfelder, Sandra Thierstein, Eric Innocents Eboulet, Britta Maurer, Janine Schniering, Hubert Szymon Gabryś, Isabelle Schmitt-Opitz, Miklos Pless, Robert Foerster, Matthias Guckenberger, Stephanie Tanadini-Lang Abstract Objectives: In this study, we aimed to assess the impact of different CT…
Read MoreMetformin Induces Apoptosis and Inhibits Notch1 in Malignant Pleural Mesothelioma Cells
Frontiers in Cell and Development Biology 2021 January 18 [Link] Marika Rossini, Fernanda Martini, Elena Torreggiani, Francesca Fortini, Giorgio Aquila, Francesco Vieceli Dalla Sega, Simone Patergnani, Paolo Pinton, Pio Maniscalco, Giorgio Cavallesco, Paola Rizzo, Mauro Tognon Abstract Malignant pleural mesothelioma (MPM) is an aggressive asbestos-related cancer arising from the mesothelial cells lining the pleural cavity.…
Read MoreMalignant pleural mesothelioma in a patient with pneumothorax: A cumbersome subtype both clinically and pathologically
Thoracic Cancer 2021 February 2 [Link] Takafumi Fukui, Takako Okubo, Naoki Tanimoto, Hiromichi Okuma, Yoshitaka Shiina, Mizuki Kohama, Jun Yamada, Yasuhiro Funada, Yoshihiro Ikura Abstract Here, we report a case of malignant pleural mesothelioma (MPM) that was very difficult to diagnose. A 62-year-old woman with a surgical history of recurrent bilateral pneumothorax was admitted to…
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