Pleural
Exploration of identifying novel serum biomarkers for malignant mesothelioma using iTRAQ combined with 2D-LC-MS/MS
Environmental Research 2020 November 13 [Link] Hailing Xia, Lingfang Feng, Lijun Lin, Zhaoqiang Jiang, Junqiang Chen, Wei Shi, Shibo Ying, Min Yu, Li Ju, Lijin Zhu, Li Shi, Xing Zhang, Jianlin Lou Abstract Malignant mesothelioma (MM) is an aggressive cancer linked to asbestos exposure. Its poor prognosis makes early diagnosis extremely important, which would provide…
Read MoreHomozygous deletion of CDKN2A in malignant mesothelioma: Diagnostic utility, patient characteristics and survival in a UK mesothelioma centre
Lung Cancer 2020 November 5 [Link] Kelly Marshall, Susan Jackson, Jennifer Jones, Jayne Holme, Judith Lyons, Emma Barrett, Paul Taylor, Paul Bishop, Clare Hodgson, Michael Green, Nicholas Telford, Matthew Evison Abstract Background: Detection of homozygous deletion of the p16 gene (CDKN2A) by fluorescence in situ hybridization (FISH) has been investigated as an ancillary technique in…
Read MoreAdvanced Symptom Management System for Patients with Malignant Pleural Mesothelioma (ASyMSmeso): Mixed Methods Study
Journal of Medical Internet Research 2020 November 12 [Link] Roma Maguire, John Connaghan, Anne Arber, Naomi Klepacz, Kevin G Blyth, John McPhelim, Paul Murray, Hitasha Rupani, Anoop Chauhan, Peter Williams, Laura McNaughton, Kirstie Woods, Anne Moylan Abstract Background: Patients with malignant pleural mesothelioma (MPM) have a life-limiting illness and short prognosis and experience many debilitating…
Read MoreEfficacy of nivolumab and ipilimumab in patients with malignant pleural mesothelioma is related to a subtype of effector memory cytotoxic T cells: Translational evidence from two clinical trials
EBioMedicine 2020 November 6 [Link] Joanne M Mankor, Maria J Disselhorst, Myrthe Poncin, Paul Baas, Joachim G J V Aerts, Heleen Vroman Abstract Background: Combined immune checkpoint inhibitor (ICI) treatment targeting PD-1 and CTLA-4 was suggested to yield clinical benefit over chemotherapy in malignant pleural mesothelioma (MPM), whereas aPD-1 monotherapy failed to provide benefit in…
Read MoreOncolytic herpesvirus therapy for mesothelioma – A phase I/IIa trial of intrapleural administration of HSV1716
Lung Cancer 2020 October 20 [Link] Sarah J Danson, Joe Conner, John G Edwards, Kevin G Blyth, Patricia M Fisher, Munitta Muthana, Abdulazeez Salawu, Fiona Taylor, Elizabeth Hodgkinson, Patrick Joyce, Jennifer Roman, Kathleen Simpson, Alexander Graham, Kirsty Learmonth, Penella J Woll Abstract Objectives: Malignant Pleural Mesothelioma (MPM) remains a major oncological challenge with limited therapeutic…
Read MoreCan BAP1 expression loss in mesothelial cells be an indicator of malignancy?
Journal of Pathology and Translational Medicine 2020 November 9 [Link] Hanife Gulnihal Ozdemir, Sermin Coban Kokten, Nagehan Ozdemir Barisik Abstract Background: Malignant mesothelioma is a highly aggressive tumor that can be confused with a benign mesothelial lesion, especially cytomorphologic lesions. BRCA1-associated protein 1 (BAP1) acts as a tumor suppressor. In this study, we aim to…
Read MoreCalcitriol Inhibits Viability and Proliferation in Human Malignant Pleural Mesothelioma Cells
Frontiers in Endocrinology 2020 October 8 [Link] Iacopo Gesmundo, Francesca Silvagno, Dana Banfi, Valentina Monica, Alessandro Fanciulli, Giacomo Gamba, Noemi Congiusta, Roberta Libener, Chiara Riganti, Ezio Ghigo, Riccarda Granata Abstract Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor, often associated with exposure to asbestos and characterized by poor prognosis and limited treatment options.…
Read MoreWidespread pulmonary invasion by malignant pleural mesothelioma: an important diagnostic consideration
Respirology Case Reports 2020 October 26 [Link] Mia MacMillan, Bapti Roy, Sally McLaren, Anna K Nowak, Rajesh Thomas, Y C Gary Lee Abstract We report a rare case of early and extensive pulmonary invasion of malignant pleural mesothelioma (MPM) in a 70-year-old woman. She first presented with a hydropneumothorax and subsequent workup, including video-assisted thoracoscopy…
Read MoreImpact of metallothionein-knockdown on cisplatin resistance in malignant pleural mesothelioma
Scientific Reports 2020 October 29 [Link] Sabrina Borchert, Pia-Maria Suckrau, Robert F H Walter, Michael Wessolly, Elena Mairinger, Julia Steinborn, Balazs Hegedus, Thomas Hager, Thomas Herold, Wilfried E E Eberhardt, Jeremias Wohlschlaeger, Clemens Aigner, Agnes Bankfalvi, Kurt Werner Schmid, Fabian D Mairinger Abstract Malignant pleural mesothelioma (MPM) is a rare, but aggressive tumor with dismal…
Read MoreComplications and Predictive Factors for Air Leak > 10 Days with Neoadjuvant Chemotherapy Followed by Pleurectomy/Decortication for Malignant Pleural Mesothelioma
Annals of Surgical Oncology 2020 October [Link] Akifumi Nakamura, Nobuyuki Kondo, Toru Nakamichi, Masaki Hashimoto, Teruhisa Takuwa, Seiji Matsumoto, Kozo Kuribayashi, Takashi Kijima, Seiki Hasegawa Abstract Background: A few studies have reported the incidence and clinical implications of complications after pleurectomy/decortication (P/D). Objective: The aim of this study was to assess the details of complications…
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