Surgery
Expression of PD-L1 in Patients With Malignant Peritoneal Mesothelioma: A Pilot Study
The Journal of Surgical Research 2022 April 27 [Link] Victor P Gazivoda, Aaron W Kangas-Dick, Alissa A Greenbaum, Joshua Roshal, Chunxia Chen, Dirk F Moore, Russell C Langan, Timothy J Kennedy, Christine Minerowicz, H Richard Alexander Abstract Introduction: Frequency of PD-L1 expression and the role of immunotherapy in malignant peritoneal mesothelioma (MPM) have not been…
Read MoreRepeat Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy for Cancers with Peritoneal Metastasis: A 30-year Institutional Experience
Annals of Surgical Oncology 2022 March 14 [Link] Cristian D Valenzuela, Edward A Levine, Christopher W Mangieri, Rohin Gawdi, Omeed Moaven, Gregory Russell, Megan E Lundy, Kathleen C Perry, Konstantinos I Votanopoulos, Perry Shen Abstract Background: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) improves survival in abdominal cancer patients with metastatic disease limited to the…
Read MoreControl of air leakage during pleurectomy/decortication by the ventilation and anchoring method
General Thoracic and Cardiovascular Surgery 2022 February 28 [Link] Masaki Hashimoto, Nobuyuki Kondo, Toru Nakamichi, Akifumi Nakamura, Ayumi Kuroda, Teruhisa Takuwa, Seiji Matsumoto, Seiki Hasegawa Abstract Objectives: We previously established a novel method of lung repair called the ventilation and anchoring (V/A) method. We evaluated the usefulness of the V/A method for controlling air leakage…
Read MoreNovel and Future Treatment Options in Mesothelioma: A Systematic Review
International Journal of Molecular Sciences 2022 February 10 [Link] Danijela Štrbac, Vita Dolžan Abstract Mesothelioma is a rare tumor, frequently associated with asbestos exposure, arising from pleura and peritoneum. Traditionally, diagnosis and treatment have been difficult in a clinical setting. The treatment is based on a trimodal approach involving surgery, chemotherapy, and radiotherapy. The introduction…
Read MoreSalvage debulking surgery and hyperthermic intrathoracic chemotherapy for massive recurrent mesothelioma in the mediastinum
Interactive Cardiovascular and Thoracic Surgery 2022 February 26 [Link] Shi Sum Poon, Caterina Alberti, Marco Nardini, Marcello Migliore Abstract Mediastinal malignant pleural mesothelioma with signs of tamponade is rare. Indication for reoperation for recurrent malignant pleural mesothelioma is a controversial but viable option in selected patients. We report a case of a 68-year-old man presenting…
Read MoreSarcopenia, Precardial Adipose Tissue and High Tumor Volume as Outcome Predictors in Surgically Treated Pleural Mesothelioma
Diagnostics (Basel) 2022 January 3 [Link] Oliver Guido Verhoek, Lisa Jungblut, Olivia Lauk, Christian Blüthgen, Isabelle Opitz, Thomas Frauenfelder, Katharina Martini Abstract Background: We evaluated the prognostic value of Sarcopenia, low precardial adipose-tissue (PAT), and high tumor-volume in the outcome of surgically-treated pleural mesothelioma (PM). Methods: From 2005 to 2020, consecutive surgically-treated PM-patients having a…
Read MoreSurgical strategy for malignant pleural mesothelioma: the superiority of pleurectomy/decortication
Surgery Today 2022 January 19 [Link] Masatoshi Kanayama, Masataka Mori, Hiroki Matsumiya, Akihiro Taira, Shinji Shinohara, Masaru Takenaka, Koji Kuroda, Fumihiro Tanaka Abstract Purpose: Both extrapleural pneumonectomy (EPP) and pleurectomy/decortication (P/D) are used for the surgical treatment of malignant pleural mesothelioma (MPM). This study aimed to compare the operative and clinical outcomes and survival between…
Read MoreBiological Pathways Associated With the Development of Pulmonary Toxicities in Mesothelioma Patients Treated With Radical Hemithoracic Radiation Therapy: A Preliminary Study
Frontiers in Oncology 2021 December 22 [Link] Sergio Crovella, Alberto Revelant, Elena Muraro, Ronald Rodrigues Moura, Lucas Brandão, Marco Trovò, Agostino Steffan, Paola Zacchi, Giuliano Zabucchi, Emilio Minatel, Violetta Borelli Abstract Radical hemithoracic radiotherapy (RHR), after lung-sparing surgery, has recently become a concrete therapeutic option for malignant pleural mesothelioma (MPM), an asbestos-related, highly aggressive tumor…
Read MoreLong-term outcomes after lung-sparing surgery for epithelial mesothelioma
Journal of Thoracic Disease 2021 November [Link] Cristiano Breda, Simone Furia, Giuseppe Lucchini, Antonio Zaccaria, Enrico Verderi, Giuseppe Natale, Fabio Lo Giudice, Roberta Cavallin, Andrea Ferronato, Paolo Fontana Abstract Background: This observational study evaluates retrospectively the long-term outcomes after pleurectomy/decortication for pleural mesothelioma, with and without the resection/reconstruction of diaphragm and pericardium. Methods: Data from…
Read MoreQuality of Life Is Not Deteriorated After Extrapleural Pneumonectomy vs. (Extended) Pleurectomy/Decortication in Patients With Malignant Pleural Mesothelioma
Frontiers in Surgery 2021 December 8 [Link] Olivia Lauk, Miriam Patella, Thomas Neuer, Ilhan Inci, Walter Weder, Isabelle Opitz Abstract Background: Extrapleural pneumonectomy (EPP) for malignant pleural mesothelioma (MPM) is highly abandoned due to high morbidity and mortality rates and impaired quality of life (QoL). However, there are still rare indications for this intervention. The…
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