Surgery
Sarcomatoid Mesothelioma: A Clinicopathological and Immunohistochemical Study of 64 Cases
International Journal of Surgical Pathology 2021 May 3 [Link] Diana M Oramas, Michael Zaleski, Cesar A Moran Abstract Sixty-four cases of sarcomatoid pleural mesothelioma represent the basis of this study. The patients are 51 men and 13 women between the ages of 42 and 79 years, who presented with symptoms of chest pain, cough, and…
Read MoreComplete laparoscopic pelvic peritonectomy plus hyperthermic intraperitoneal chemotherapy
Techniques in Coloproctology 2020 October [Link] A Arjona-Sánchez, D Cortés-Guiral, M Duran-Martínez, P Villarejo-Campos, J M Sánchez-Hidalgo, A Casado-Adam, L Rodriguez-Ortiz, A Romero-Ruiz, B Rufian-Andujar, E Espinosa-Redondo, F Valenzuela-Molina, S Rufián-Peña, J Briceño-Delgado Abstract Background: The aim of our study was to present the technique for, and early results of complete laparoscopic pelvic peritonectomy (LPP)…
Read MoreThree Decades of Malignant Pleural Mesothelioma: An Academic Center Experience
Clinical Lung Cancer 2021 March 27 [Link] Abdullah Nasser, Andrew Baird, Mathieu D Saint-Pierre, Kayvan Amjadi, Scott Laurie, Paul Wheatley-Price Abstract Background: Malignant pleural mesothelioma (MPM) remains a challenging disease to manage. In the past few decades, extrapleural pneumonectomy (EPP), pemetrexed-based chemotherapy, and indwelling pleural catheters were introduced to MPM care with variable levels of…
Read MoreSulforaphane inhibits PRMT5 and MEP50 function to suppress the mesothelioma cancer cell phenotype
Molecular Carcinogenesis 2021 April 19 [Link] Geraldine Ezeka, Gautam Adhikary, Sivaveera Kandasamy, Joseph S Friedberg, Richard L Eckert Abstract Mesothelioma is a highly aggressive cancer of the mesothelial lining that is caused by exposure to asbestos. Surgical resection followed by chemotherapy is the current treatment strategy, but this is marginally successful and leads to drug-resistant…
Read MoreOutcomes of multicystic peritoneal mesothelioma treatment with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
BJS Open 2021 March 5 [Link] A Zahid, L Clarke, N Carr, K Chandrakumaran, A Tzivanakis, S Dayal, F Mohamed, T Cecil, B J Moran Abstract Background: Multicystic peritoneal mesothelioma (MCPM) is a rare neoplasm, generally considered a borderline malignancy, best treated by cytoreductive surgery (CRS) to remove macroscopic disease, combined with hyperthermic intraperitoneal chemotherapy…
Read MoreEliminating mesothelioma by AAV-vectored, PD1-based vaccination in the tumor microenvironment
Molecular Therapy Oncolytics 2021 January 21 [Link] Zhiwu Tan, Mei Sum Chiu, Chi Wing Yan, Kwan Man, Zhiwei Chen Abstract The potency of cancer vaccines is often compromised by a variety of immunoinhibitory mechanisms, including stimulation of the programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) immune checkpoint pathway. Here, to overcome inhibition,…
Read MoreOutcomes of Conversion to Extrapleural Pneumonectomy from Pleurectomy/Decortication for Malignant Pleural Mesothelioma
Seminars in Thoracic and Cardiovascular Surgery 2021 February 17 [Link] Akifumi Nakamura, Masaki Hashimoto, Seiji Matsumoto, Nobuyuki Kondo, Takashi Kijima, Seiki Hasegawa Abstract In recent years, there has been a shift from extrapleural pneumonectomy (EPP) toward pleurectomy/decortication (P/D) as the preferred surgical technique. However, we occasionally encounter difficult cases wherein visceral pleurectomy requires conversion to…
Read MoreOutcomes of Conversion to Extrapleural Pneumonectomy from Pleurectomy/Decortication for Malignant Pleural Mesothelioma
Seminars in Thoracic and Cardiovascular Surgery 2021 February 17 [Link] Akifumi Nakamura, Masaki Hashimoto, Seiji Matsumoto, Nobuyuki Kondo, Takashi Kijima, Seiki Hasegawa Abstract In recent years, there has been a shift from extrapleural pneumonectomy (EPP) toward pleurectomy/decortication (P/D) as the preferred surgical technique. However, we occasionally encounter difficult cases wherein visceral pleurectomy requires conversion to…
Read MoreRecurrence of mesothelioma after a macroscopic complete resection procedure: is a second radical surgery justified?
Interactive Cardiovascular and Thoracic Surgery 2021 January 26 [Link] Hany Hasan Elsayed, Aly Sherif Hassaballa, Taha Aly Ahmed, Hazem Youssef Sharkawy Abstract A best evidence topic was written according to a structured protocol. The question addressed was: In patients with mesothelioma who develop a local recurrence after macroscopic complete resection (MCR) surgery, does performing a…
Read MoreSurgery for malignant pleural mesothelioma after radiotherapy (SMART): final results from a single-centre, phase 2 trial
The Lancet Oncology 2021 January 12 [Link] B C John Cho, Laura Donahoe, Penelope A Bradbury, Natasha Leighl, Shaf Keshavjee, Andrew Hope, Prodipto Pal, Michael Cabanero, Kasia Czarnecka, Karen McRae, Ming-Sound Tsao, Marc de Perrot Abstract Background: A novel approach for managing malignant pleural mesothelioma, surgery for mesothelioma after radiotherapy (SMART), consisting of a short…
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