Surgery
Phase I Clinical Trial on Pleural Mesothelioma Using Neoadjuvant Local Administration of Paclitaxel-Loaded Mesenchymal Stromal Cells (PACLIMES Trial): Study Rationale and Design
Cancers 2024 October 4 [Link] Giulia Maria Stella, Daniela Lisini, Paolo Pedrazzoli, Giulia Galli, Chandra Bortolotto, Giulio Melloni, Gioacchino D’Ambrosio, Catherine Klersy, Amelia Grosso, Francesca Paino, Stefano Tomaselli, Laura Saracino, Giulio Alessandri, Augusto Pessina, Elena Grignani, Vittorio Rosti, Angelo Guido Corsico, Patrizia Comoli, Francesco Agustoni Abstract Background and rationale. Pleural mesothelioma (PM) is a rare…
Read MoreThe Significance of the Morphological Appearance of Peritoneal Lesions on Imaging in Patients With Peritoneal Malignancies-A Report From Phase 1 of the PRECINCT Study
Journal of Surgical Oncology 2024 September 19 [Link] Aditi Bhatt, Pascal Rousset, Brendan J Moran, Mudaddal Kazi, Dario Baratti, Amine Souadka, Marcello Deraco, Paolo Sammartino, Armando Sardi, Olivier Glehen Abstract Peritoneal tumour dissemination is still considered as a terminal disease. For the last two decades, cytoreductive surgery (CRS) combined with intraoperative hyperthermic chemotherapy (HIPEC) has…
Read MorePerfusion Strategies for Cytoreductive Surgery With Heated Intraperitoneal Chemotherapy for Malignant Peritoneal Mesothelioma
Journal of Surgical Oncology 2024 September 10 [Link] Claire Drigotas, Alexander W Loftus, John B Ammori, Luke D Rothermel, Richard S Hoehn Abstract Cytoreductive surgery (CRS) with heated intraoperative intraperitoneal chemotherapy (HIPEC) has been shown to improve survival for patients with malignant peritoneal mesothelioma (MPM). Presently, there is no standardized HIPEC protocol with respect to…
Read MoreClinical Characteristics and Outcomes of Patients with Well-Differentiated Papillary Peritoneal Mesothelial Tumors
Annals of Surgical Oncology 2024 November [Link] Michael Offin, Nicole Aguirre, Soo Ryum Yang, Jennifer L Sauter, Georgios Karagkounis, Mostafa Mohamed, Andrea Cercek, Ritika Kundra, Yanming Zhang, Hui Mei Wang, Marty P Morris, Marc Ladanyi, Garrett M Nash, Marjorie G Zauderer Abstract Purpose: Well-differentiated papillary peritoneal mesothelial tumors (WDPMTs) are understudied and discrete from peritoneal…
Read MoreStemness and hybrid epithelial-mesenchymal profiles guide peritoneal dissemination of malignant mesothelioma and pseudomyxoma peritonei
International Journal of Cancer 2024 August 15 [Link] Nayana Lazzari, Giulia Rigotto, Barbara Montini, Paola Del Bianco, Elena Moretto, Federica Palladino, Rocco Cappellesso, Marco Tonello, Carola Cenzi, Antonio Scapinello Maria Assunta Piano, Carlo Riccardo Rossi, Piero Dalerba, Pierluigi Pilati, Antonio Sommariva, Maria Luisa Calabrò Abstract Intrabdominal dissemination of malignant mesothelioma (MM) and pseudomyxoma peritonei (PMP)…
Read MorePeritoneal Dissemination in Patients with Recurrence After Post-pleurectomy/decortication for Pleural Mesothelioma
Annals of Surgical Oncology 2024 August 10 [Link] Akifumi Nakamura, Masaki Hashimoto, Ayumi Kuroda, Kyoshiro Takegahara, Akihiro Fukuda, Seiji Matsumoto, Nobuyuki Kondo, Toshiyuki Minami, Kazuhiro Kitajima, Kozo Kuribayashi, Takashi Kijima, Soichiro Funaki, Seiki Hasegawa Abstract Background: In clinical practice, peritoneal dissemination after curative-intent surgery for pleural mesothelioma occasionally recurs. This study investigated the risk factors…
Read MoreQuality of Life After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS/HIPEC): Cancer Survivors’ Perspective Through In-Depth Interviews
Annals of Surgical Oncology 2024 July 26 [Link] Luis Felipe Falla-Zuniga, Mary Caitlin King, Kathleen Pawlikowski, Andrei Nikiforchin, Felipe Lopez-Ramirez, Philipp Barakat, Sergei Iugai, Carol Nieroda, Vadim Gushchin, Armando Sardi Abstract Background: CRS/HIPEC patients face unique quality of life (QoL) challenges due to advanced disease (peritoneal carcinomatosis), the extent of procedure, and risk for long-term…
Read MoreThe Role of Hyperthermic Intrathoracic Chemotherapy (HITHOC) in Thoracic Tumors
Cancers 2024 July 11 [Link] Federica Danuzzo, Maria Chiara Sibilia, Sara Vaquer, Andrea Cara, Enrico Mario Cassina, Lidia Libretti, Emanuele Pirondini, Federico Raveglia, Antonio Tuoro, Francesco Petrella Abstract Pleural mesothelioma (PM) is a rare but aggressive thoracic tumor with a poor prognosis. Multimodal treatment-including induction chemotherapy, aggressive surgical resection, radiotherapy and immunotherapy in selected cases-currently…
Read MoreComprehensive Pulmonary Rehabilitation for Patients with Malignant Pleural Mesothelioma: A Feasibility Pilot Study
Cancers 2024 May 26 [Link] Lorenzo Lippi, Alessandro de Sire, Arianna Folli, Claudio Curci, Dario Calafiore, Mariano Lombardi, Luca Bertolaccini, Alessio Turco, Antonio Ammendolia, Nicola Fusco, Lorenzo Spaggiari, Marco Invernizzi Abstract Malignant pleural mesothelioma (MPM) represents a significant health burden, with limited treatment options and poor prognosis. Despite advances in pharmacological and surgical interventions, the…
Read MoreA randomised phase II study of extended pleurectomy/decortication (e-PD) preceded or followed by chemotherapy in patients (pts) with early-stage pleural mesothelioma (PM): EORTC 1205
The European Respiratory Journal 2024 June 26 [Link] Jo Raskin, Veerle Surmont, Alexander P W M Maat, Maha Yahia, Sjaak A Burgers, Yassin Pretzenbacher, Frederic De Ryck, Robin Cornelissen, Houke M Klomp, Ana Oliveira, Joachim Aerts, Paul Baas, Sandrine Marreaud, Jan P Van Meerbeeck, Paul E Y Van Schil Abstract Background: The role of surgery…
Read More