Surgery
Prognostic importance of the neutrophil-to-lymphocyte ratio in malignant peritoneal mesothelioma patients receiving cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
BMC Cancer 2025 February 14 [Link] Zhang Xinjing, Gong Lei, Li Xinbao, Ji Zhonghe, Yang Zhiran, Gao Chao, Zhang Kai, Yan Lijun, Yan Guojun, Yu Junhui, Zhang Yanbin, An Songlin Abstract Background: Malignant peritoneal mesothelioma (MPM) is a rare but aggressive cancer. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) was the preferred choice for…
Read MoreCurrent Status of Staging and Restaging Malignant Pleural Mesothelioma
Seminars in Nuclear Medicine 2025 March [Link] Egesta Lopci Malignant pleural mesothelioma (MPM) is the most frequent aggressive tumor affecting the pleura, accounting for over 38,000 deaths worldwide. It originates from the mesothelial cells and is mostly associated to asbestos exposure. Depending on the extent of the disease, the management of MPM varies from surgical…
Read MoreRadiotherapy of the pleural cavity in patients with primary and secondary malignancies of the pleura
Reports of Practical Oncology and Radiotherapy 2024 October 3 [Link] Dimcho Georgiev, Marija Jankova, Bozhidar Krastev, Svetlana Bilyukova Abstract Background: Although there have been various attempts to find appropriate treatment from best conservative care to multimodal treatments, curative outcomes remain poor. Materials and methods: 30 patients with primary and secondary malignant tumors of the pleura…
Read MoreCytoreductive surgery in diffuse pleural mesothelioma. What have we learnt from MARS2, EORTC-L1205 and other recent studies?
European Journal of Surgical Oncology 2925 January 21 [Link] Loïc Lang-Lazdunski Abstract Cytoreductive surgery remains controversial in pleural mesothelioma. The MARS2 trial suggested that extended pleurectomy decortication following neoadjuvant chemotherapy was associated with no survival benefit, more serious adverse events and poorer quality of life than systemic chemotherapy alone in patients with resectable pleural mesothelioma.…
Read MoreRecurrence Patterns and Management after Pleurectomy Decortication for Pleural Mesothelioma
Annals of Surgery 2025 January 15 [Link] Juuso Paajanen, William G Richards, Yue Xie, Emanuele Mazzola, Kristina Sidopoulos, John Kuckelman, Ritu R Gill, Raphael Bueno Abstract Objective: We hypothesize that recurrence following pleurectomy decortication (PD) is primarily local. We explored factors associated with tumor recurrence patterns, disease-free interval (DFI), and post-recurrence survival (PRS). Summary background…
Read MoreSurgical indications for pleurectomy/decortication in pleural mesothelioma based on the newly revised 9th edition of the tumour-node-metastasis classification
Interdisciplinary Cardiovascular and Thoracic Surgery 2024 December 25 [Link] Masatoshi Kanayama, Masaru Takenaka, Takehiko Manabe, Katsuma Yoshimatsu, Rintaro Oyama, Hiroki Matsumiya, Masataka Mori, Koji Kuroda, Fumihiro Tanaka Abstract Objectives: The MARS2 trial questioned the efficacy of curative intent surgery for pleural mesothelioma (PM), while real-world clinical data from Japan suggest a favourable prognosis in surgical…
Read MoreSurgery for pleural mesothelioma in multimodality setting: comparison between surgical techniques in a high-volume centre
European Journal of Cardio-Thoracic Surgery 2024 November 28 [Link] Eleonora Faccioli, Andrea Dell’Amore, Giulia Lorenzoni, Marco Schiavon, Gianluca Canu, Giulia Pasello, Giovanni Zambello, Matteo Sepulcri, Viola Sambataro, Francesco Labella, Chiara Giraudo, Dario Gregori, Fiorella Calabrese, Federico Rea Abstract Objectives: Pleural mesothelioma (PM) is an aggressive disease linked to asbestos exposure, presenting significant treatment challenges. The…
Read MoreReconstruction of diaphragm with cadaveric fascia lata during extended surgery for pleural mesothelioma: A single-center experience
European Journal of Surgical Oncology 2025 January [Link] Eleonora Faccioli, Giovanni Zambello, Diletta Trojan, Gianluca Canu, Viola Sambataro, Chiara Giraudo, Marco Schiavon, Andrea Dell’Amore, Federico Rea Abstract Introduction: Synthetic materials have traditionally been used to reconstruct the diaphragm during extensive surgery for pleural mesothelioma. However, new biomaterials have shown promising results in various surgical fields.…
Read MoreLong-term survival from multidisciplinary treatment of primary malignant pericardial mesothelioma: A case report
International Journal of Surgery Case Reports 2024 December [Link] Vu Anh Hai, Nghiem Thi Minh Chau, Ho Viet Hoanh, Ha Van Tri, Dinh Cong Pho, Nguyen Van Nam Abstract Introduction and importance: Primary malignant pericardial mesothelioma is an extremely rare disease with a poor prognosis. Currently, there are no specific guidelines for diagnosis and treatment…
Read MoreThe impact of age on the efficacy of radiotherapy in pleural mesothelioma patients receiving trimodality therapy: a population-based study of the SEER database
Journal of Thoracic Disease 2024 October 31 [Link] Jun Yang, Liang Xia, Hui Jie, Tengyong Wang, Chenglin Guo, Chengwu Liu, Hu Liao, Jiandong Mei, Qiang Pu, Lunxu Liu Abstract Background: Pleural mesothelioma (PM) is a highly aggressive tumor with poor survival outcomes. The role of additional radiotherapy for PM patients who have received surgery and…
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