Occupational Asbestos Exposure
Incidence of mesothelioma and asbestosis by occupation in a diverse workforce
American Journal of Industrial Medicine 2021 April 8 [Link] Nathan L DeBono, Hunter Warden, Chloë Logar-Henderson, Sharara Shakik, Mamadou Dakouo, Jill MacLeod, Paul A Demers Abstract Objective: We sought to characterize detailed patterns of mesothelioma and asbestosis incidence in the workforce as part of an occupational disease surveillance program in Ontario, Canada. Methods: The Occupational…
Read MoreClinical prognostic factors in pleural mesothelioma: best supportive care and anti-tumor treatments in a real-life setting
Acta Oncologica 2021 January 27 [Link] Thomas Ringgaard Petersen, Vasiliki Panou, Christos Meristoudis, Ulla Møller Weinreich, Oluf Dimitri Røe Abstract Background: This study aims to investigate patient- and disease characteristics associated with survival in malignant pleural mesothelioma (MPM) patients with anti-tumor treatment or with best supportive care (BSC). Materials and methods: Consecutive MPM cases diagnosed…
Read MoreLiving with mesothelioma: A qualitative study of the experiences of male military veterans in the UK
European Journal of Oncology Nursing 2020 December 19 [Link] Stephanie Ejegi-Memeh, Liz Darlison, Anne Moylan, Angela Tod, Virginia Sherborne, Clare Warnock, Bethany Hope Taylor Abstract Purpose: The UK has the highest incidence of mesothelioma in the world. Evidence in the United States suggests that mesothelioma may disproportionately affect military veterans. However, there has been no…
Read MoreCalcitriol Inhibits Viability and Proliferation in Human Malignant Pleural Mesothelioma Cells
Frontiers in Endocrinology 2020 October 8 [Link] Iacopo Gesmundo, Francesca Silvagno, Dana Banfi, Valentina Monica, Alessandro Fanciulli, Giacomo Gamba, Noemi Congiusta, Roberta Libener, Chiara Riganti, Ezio Ghigo, Riccarda Granata Abstract Malignant pleural mesothelioma (MPM) is a rare and aggressive tumor, often associated with exposure to asbestos and characterized by poor prognosis and limited treatment options.…
Read MoreMesothelioma risk among those exposed to chrysotile asbestos only and mixtures that include amphibole: a case-control study in the USA, 1975-1980
Occupational and Environmental Medicine 2020 October 21 [Link] Jason Y Y Wong, Carol Rice, Aaron Blair, Debra T Silverman Abstract Objectives: Occupational asbestos exposure is causally linked to mesothelioma. However, whether exposure to only chrysotile asbestos is associated with mesothelioma risk, and the heterogeneity in risk by different fibre types/lengths remains unclear. We investigated whether…
Read MoreThe influence of genetic variability in IL1B and MIR146A on the risk of pleural plaques and malignant mesothelioma
Radiology and Oncology 2020 October 21 [Link] Petra Piber, Neza Vavpetic, Katja Goricar, Vita Dolzan, Viljem Kovac, Alenka Franko Abstract Background Asbestos exposure is associated with the development of pleural plaques as well as malignant mesothelioma (MM). Asbestos fibres activate macrophages, leading to the release of inflammatory mediators including interleukin 1 beta (IL-1β). The expression…
Read MoreEffect of asbestos exposure on differentiation and function of cytotoxic T lymphocytes
Environmental Health and Preventative Medicine 2020 October 8 [Link] Naoko Kumagai-Takei, Yasumitsu Nishimura, Megumi Maeda, Hiroaki Hayashi, Hidenori Matsuzaki, Suni Lee, Kei Yoshitome, Tatsuo Ito, Takemi Otsuki Abstract Asbestos exposure is known to cause malignant mesothelioma, which is associated with poor prognosis. We focused on and examined the effect of asbestos exposure on the differentiation…
Read MoreThe potential utility of GATA binding protein 3 for diagnosis of malignant pleural mesotheliomas
Human Pathology 2020 September 2 [Link] Sarita Prabhakaran, Ashleigh Hocking, Chankyung Kim, Matthew Hussey, Sonja Klebe Abstract Malignant pleural mesothelioma is associated with asbestos exposure and poor outcomes. The usefulness of immunohistochemistry for diagnosis of sarcomatoid mesothelioma, especially the desmoplastic type, is limited, and more effective markers are required. GATA binding protein 3 (GATA3) has…
Read MoreEvaluation of Nonresponse Bias in a Case-Control Study of Pleural Mesothelioma
International Journal of Environmental Research and Public Health 2020 August 24 [Link] Chiara Airoldi, Daniela Ferrante, Dario Mirabelli, Danila Azzolina, Corrado Magnani Abstract Nonparticipation limits the power of epidemiological studies, and can cause bias. In a case-control study on pleural malignant mesothelioma (MM), we found low participation in interviews (63%) among controls. Our goal was…
Read MoreNew vistas in malignant mesothelioma: MicroRNA architecture and NRF2/MAPK signal transduction
Life Sciences 2020 July 22 [Link] Manav Gandhi, Sujit Nair Abstract Malignant mesothelioma (MM) is a cancer of the mesothelial lining of the pleura, peritoneum, pericardium and testes. The most common form is asbestos-linked MM that is etiologically linked to repeated asbestos exposure with a long latency period, although non-asbestos MM has also been reported.…
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