Occupational Asbestos Exposure
Primary Peritoneal Mesothelioma Affecting the Greater Omentum That Mimicked an Omental Infarction: A Case Report
Case Reports in Oncology 2024 May 30 [Link] John Corbyn Cravero, Taylor Yakubik, Laith Wahab, Thao Giang, Lisa M Lopez, Megan G Newman Abstract Introduction: Malignant peritoneal mesothelioma (MPM) is a rare cancer that is associated with asbestos exposure. The diagnosis can be difficult given the nonspecific nature of presenting symptoms and the presence of…
Read MoreIncidental Diagnosis of Malignant Peritoneal Mesothelioma During Liver Transplantation Surgery: A Case Report
The American Journal of Case Reports 2024 July 17 [Link] Spogmai Khan, Adnan Malik, Shahbaz Qureshi, Babak Cohen, Abdul Nadir Abstract BACKGROUND Malignant peritoneal mesothelioma (MPM) is a rare, lethal tumor of serous membranes. The most common factor reported in association with MPM is asbestos exposure, while viral infections, genetic predisposition, paraneoplastic syndrome, and altered…
Read MoreGermline BARD1 variants predispose to mesothelioma by impairing DNA repair and calcium signaling
Proceedings of the National Academy of Sciences of the United States of America 2024 July 16 [Link] Flavia Novelli, Yoshie Yoshikawa, Veronica Angela Maria Vitto, Lorenzo Modesti, Michael Minaai, Sandra Pastorino, Mitsuru Emi, Jin-Hee Kim, Franz Kricek, Fang Bai, José N Onuchic, Angela Bononi, Joelle S Suarez, Mika Tanji, Cristina Favaron, Alicia A Zolondick, Ronghui…
Read MoreTargeting inflammatory factors for chemoprevention and cancer interception to tackle malignant mesothelioma
Oncoscience 2024 May 23 [Link] Joseph R Testa, Yuwaraj Kadariya, Joseph S Friedberg Abstract Mesothelioma is an incurable cancer of the mesothelial lining often caused by exposure to asbestos. Asbestos-induced inflammation is a significant contributing factor in the development of mesothelioma, and genetic factors also play a role in the susceptibility to this rapidly progressive…
Read MoreTargeting inflammatory factors for chemoprevention and cancer interception to tackle malignant mesothelioma
Oncoscience 2024 May 23 [Link] Joseph R Testa, Yuwaraj Kadariya, Joseph S Friedberg Abstract Mesothelioma is an incurable cancer of the mesothelial lining often caused by exposure to asbestos. Asbestos-induced inflammation is a significant contributing factor in the development of mesothelioma, and genetic factors also play a role in the susceptibility to this rapidly progressive…
Read MoreDiffuse pleural mesotheliomas with genomic near-haploidization: a newly recognized subset with distinct clinical, histologic, and molecular features
Clinical Cancer Research 2024 April 7 [Link] Soo-Ryum Yang, Gowtham Jayakumaran, Jamal Benhamida, Christopher A Febres Aldana, Rachel Fanaroff, Jason Chang, Erika Gedvilaite, Liliana B Villafania, Jennifer L Sauter, Michael Offin, Marjorie G Zauderer, Marc Ladanyi Abstract Purpose: Diffuse pleural mesotheliomas (DPMs) with genomic near-haploidization (GNH) represent a novel subtype first recognized by the TCGA…
Read MoreDevelopment of Patient and Caregiver Conceptual Models Investigating the Health-Related Quality of Life Impacts of Malignant Pleural Mesothelioma
The Patient 2024 April 15 [Link] Adam E J Gibson, Waqas Ahmed, Louise Longworth, Bryan Bennett, Melinda Daumont, Liz Darlison Abstract Background: Malignant pleural mesothelioma (MPM) is a rare and usually fatal malignancy frequently linked to occupational asbestos exposures and associated with poor prognosis and considerable humanistic burden. The study aimed to develop conceptual models…
Read MoreLow Exposures to Amphibole or Serpentine Asbestos in Germline Bap1-mutant Mice Induce Mesothelioma Characterized by an Immunosuppressive Tumor Microenvironment
Cancer Research Communications 2024 April 8 [Link] Yuwaraj Kadariya, Eleonora Sementino, Maggie Ruan, Mitchell Cheung, Parham Hadikhani, Hatice U Osmanbeyoglu, Andres J Klein-Szanto, Kathy Cai, Joseph R Testa Abstract Asbestos and BAP1 germline mutations are risk factors for malignant mesothelioma (MM). While it is well accepted that amphibole asbestos is carcinogenic, the role of serpentine…
Read MoreThe Impact of 3D Nichoids and Matrix Stiffness on Primary Malignant Mesothelioma Cells
Genes 2024 February 1 [Link] Stefania Oliveto, Paolo Ritter, Giorgia Deroma, Annarita Miluzio, Chiara Cordiglieri, Mauro Roberto Benvenuti, Luciano Mutti, Manuela Teresa Raimondi, Stefano Biffo Abstract Malignant mesothelioma is a type of cancer that affects the mesothelium. It is an aggressive and deadly form of cancer that is often caused by exposure to asbestos. At…
Read MorePleural Mesothelioma: Advances in Blood and Pleural Biomarkers
Journal of Clinical Medicine 2023 November 9 [Link] Claudio Sorino, Michele Mondoni, Giampietro Marchetti, Sergio Agati, Riccardo Inchingolo, Federico Mei, Sara Flamini, Filippo Lococo, David Feller-Kopman Abstract Pleural mesothelioma (PM) is a type of cancer that is highly related to exposure to asbestos fibers. It shows aggressive behavior, and the current therapeutic approaches are usually…
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