Occupational Asbestos Exposure
Matrix Metalloproteinases as Biomarkers and Treatment Targets in Mesothelioma: A Systematic Review
Biomolecules 2021 August 25 [Link] Danijela Štrbac, Vita Dolžan Abstract Metalloproteinases (MMPs) have an important role in tissue remodeling and have been shown to have an effect on tumor progression, invasion, metastasis formation, and apoptosis in several tumors, including mesothelioma. Mesothelioma is a rare tumor arising from pleura and peritoneum and is frequently associated with…
Read MoreEnvironmental asbestos exposure and clustering of malignant mesothelioma in community: a spatial analysis in a population-based case-control study
Environmental Health 2021 September 15 [Link] C Airoldi, C Magnani, F Lazzarato, D Mirabelli, S Tunesi, D Ferrante Abstract Background: Neighborhood exposure to asbestos increases the risk of developing malignant mesothelioma (MM) in residents who live near asbestos mines and asbestos product plants. The area of Casale Monferrato (Northwest Italy) was impacted by several sources…
Read MoreProfile of soluble factors in pleural effusions predict prognosis in mesothelioma
Cancer Biomarkers 2021 August 24 [Link] I M Dick, Y C G Lee, H M Cheah, A Miranda, B W S Robinson, J Creaney Abstract Background: Pleural mesothelioma is a deadly asbestos induced cancer. Less than 10% of mesothelioma patients survive 5 years post diagnosis. However survival can range from a few months to a…
Read MoreNew DNA Methylation Signals for Malignant Pleural Mesothelioma Risk Assessment
Cancers (Basel) 2021 May 27 [Link] Giovanni Cugliari, Alessandra Allione, Alessia Russo, Chiara Catalano, Elisabetta Casalone, Simonetta Guarrera, Federica Grosso, Daniela Ferrante, Marika Sculco, Marta La Vecchia, Chiara Pirazzini, Roberta Libener, Dario Mirabelli, Corrado Magnani, Irma Dianzani, Giuseppe Matullo Abstract Malignant pleural mesothelioma (MPM) is a rare and aggressive neoplasm. Patients are usually diagnosed when…
Read MoreThe usefulness of biomarkers in diagnosis of asbestos-induced malignant pleural mesothelioma
Human and Experimental Toxicology 2021 May 17 [Link] Zübeyde Tanrıverdi, Fatih Meteroglu, Hande Yüce, Abdurrahman Şenyiğit, Mümtaz Işcan, Songül Unüvar Abstract Introduction: Malignant pleural mesothelioma (MPM) is a malignant tumor that is associated mostly with asbestos exposure. The present study was to evaluates the diagnostic value of neopterin, periostin, YKL-40, Tenascin-C (TNC), and Indolamine 2,3-dioxygenase…
Read MoreEmerging avenues in immunotherapy for the management of malignant pleural mesothelioma
BMC Pulmonary Medicine 2021 May 5 [Link] Steven G Gray Abstract Background: The role of immunotherapy in cancer is now well-established, and therapeutic options such as checkpoint inhibitors are increasingly being approved in many cancers such as non-small cell lung cancer (NSCLC). Malignant pleural mesothelioma (MPM) is a rare orphan disease associated with prior exposure…
Read MoreGender and the experiences of living with mesothelioma: A thematic analysis
European Journal of Oncology Nursing 2021 April 28 [Link] Stephanie Ejegi-Memeh, Steve Robertson, Bethany Taylor, Liz Darlison, Angela Tod Abstract Purpose: Mesothelioma is a terminal cancer caused by exposure to asbestos. As a cancer with a higher rate in men than women, women’s experiences of living with mesothelioma are often underexplored. Furthermore, men’s experiences are…
Read More[The Current Therapy of Asbestos-Associated Malignant Pleural Mesothelioma – An Expert Consensus Paper]
Pneumologie 2021 May 4 [Link] C Aigner, T Brüning, W E E Eberhardt, M Härter, H-P Kaelberlah, M Metzenmacher, R Shah, C Taube, M Thomas Abstract Asbestos-related mesotheliomas belong to the group of the most frequent occupational diseases in Germany, reaching about 1,000 new cases per year. The disease has a dismal prognosis because most…
Read MoreA nontoxic dose of chrysotile can malignantly transform Met-5A cells, in which microRNA-28 has inhibitory effects
Journal of Applied Toxicology 2021 April 22 [Link] Fangfang Zhang, Xiuyuan Yuan, Hongjing Sun, Xianhong Yin, Yanan Gao, Min Zhang, Zhenyu Jia, Min Yu, Shibo Ying, Hailing Xia, Li Ju, Yun Xiao, He Tao, Jianlin Lou, Lijin Zhu Abstract Chrysotile, which is classified as a class I carcinogen by the International Agency for Research on…
Read MoreEffect of IL-15 addition on asbestos-induced suppression of human cytotoxic T lymphocyte induction
Environmental Health and Preventive Medicine 2021 [Link] Naoko Kumagai-Takei, Yasumitsu Nishimura, Hidenori Matsuzaki, Suni Lee, Kei Yoshitome, Tatsuo Ito, Takemi Otsuki Abstract Background: Asbestos fibers possess tumorigenicity and are thought to cause mesothelioma. We have previously reported that exposure to asbestos fibers causes a reduction in antitumor immunity. Asbestos exposure in the mixed lymphocyte reaction…
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