Targeting inflammatory factors for chemoprevention and cancer interception to tackle malignant mesothelioma

Oncoscience 2024 May 23 [Link] Joseph R Testa, Yuwaraj Kadariya, Joseph S Friedberg Abstract Mesothelioma is an incurable cancer of the mesothelial lining often caused by exposure to asbestos. Asbestos-induced inflammation is a significant contributing factor in the development of mesothelioma, and genetic factors also play a role in the susceptibility to this rapidly progressive…

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Targeting inflammatory factors for chemoprevention and cancer interception to tackle malignant mesothelioma

Oncoscience 2024 May 23 [Link] Joseph R Testa, Yuwaraj Kadariya, Joseph S Friedberg Abstract Mesothelioma is an incurable cancer of the mesothelial lining often caused by exposure to asbestos. Asbestos-induced inflammation is a significant contributing factor in the development of mesothelioma, and genetic factors also play a role in the susceptibility to this rapidly progressive…

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Diffuse pleural mesotheliomas with genomic near-haploidization: a newly recognized subset with distinct clinical, histologic, and molecular features

Clinical Cancer Research 2024 April 7 [Link] Soo-Ryum Yang, Gowtham Jayakumaran, Jamal Benhamida, Christopher A Febres Aldana, Rachel Fanaroff, Jason Chang, Erika Gedvilaite, Liliana B Villafania, Jennifer L Sauter, Michael Offin, Marjorie G Zauderer, Marc Ladanyi Abstract Purpose: Diffuse pleural mesotheliomas (DPMs) with genomic near-haploidization (GNH) represent a novel subtype first recognized by the TCGA…

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Development of Patient and Caregiver Conceptual Models Investigating the Health-Related Quality of Life Impacts of Malignant Pleural Mesothelioma

The Patient 2024 April 15 [Link] Adam E J Gibson, Waqas Ahmed, Louise Longworth, Bryan Bennett, Melinda Daumont, Liz Darlison Abstract Background: Malignant pleural mesothelioma (MPM) is a rare and usually fatal malignancy frequently linked to occupational asbestos exposures and associated with poor prognosis and considerable humanistic burden. The study aimed to develop conceptual models…

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Low Exposures to Amphibole or Serpentine Asbestos in Germline Bap1-mutant Mice Induce Mesothelioma Characterized by an Immunosuppressive Tumor Microenvironment

Cancer Research Communications 2024 April 8 [Link] Yuwaraj Kadariya, Eleonora Sementino, Maggie Ruan, Mitchell Cheung, Parham Hadikhani, Hatice U Osmanbeyoglu, Andres J Klein-Szanto, Kathy Cai, Joseph R Testa Abstract Asbestos and BAP1 germline mutations are risk factors for malignant mesothelioma (MM). While it is well accepted that amphibole asbestos is carcinogenic, the role of serpentine…

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The Impact of 3D Nichoids and Matrix Stiffness on Primary Malignant Mesothelioma Cells

Genes 2024 February 1 [Link] Stefania Oliveto, Paolo Ritter, Giorgia Deroma, Annarita Miluzio, Chiara Cordiglieri, Mauro Roberto Benvenuti, Luciano Mutti, Manuela Teresa Raimondi, Stefano Biffo Abstract Malignant mesothelioma is a type of cancer that affects the mesothelium. It is an aggressive and deadly form of cancer that is often caused by exposure to asbestos. At…

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Pleural Mesothelioma: Advances in Blood and Pleural Biomarkers

Journal of Clinical Medicine 2023 November 9 [Link] Claudio Sorino, Michele Mondoni, Giampietro Marchetti, Sergio Agati, Riccardo Inchingolo, Federico Mei, Sara Flamini, Filippo Lococo, David Feller-Kopman Abstract Pleural mesothelioma (PM) is a type of cancer that is highly related to exposure to asbestos fibers. It shows aggressive behavior, and the current therapeutic approaches are usually…

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The role of single nucleotide polymorphisms related to iron homeostasis in mesothelioma susceptibility after asbestos exposure: a genetic study on autoptic samples

Frontiers in Public Health 2023 October 24 [Link] Pierangela Grignani, Silvia Damiana Visonà, Maria Vittoria Fronda, Paola Borrelli, Maria Cristina Monti, Barbara Bertoglio, Adelaide Conti, Paolo Fattorini, Carlo Previderè Abstract Asbestos-related diseases still represent a major public health problem all over the world. Among them, malignant mesothelioma (MM) is a poor-prognosis cancer, arising from the…

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Preventive and therapeutic opportunities: targeting BAP1 and/or HMGB1 pathways to diminish the burden of mesothelioma

Journal of Translational Medicine 2023 October 25 [Link] Michele Carbone, Michael Minaai, Yasutaka Takinishi, Ian Pagano, Haining Yang Abstract Mesothelioma is a cancer typically caused by asbestos. Mechanistically, asbestos carcinogenesis has been linked to the asbestos-induced release of HMGB1 from the nucleus to the cytoplasm, where HMGB1 promotes autophagy and cell survival, and to the…

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