Occupational Asbestos Exposure
Assessment protocol of mesothelioma and relevance of SEM-EDS analysis through a case studies of legal medicine of Brescia (Italy)
Legal Medicine 2022 April 22 [Link] Francesca Maghin, Anna Antonietti, Nicoletta Cerri, Liliana Maria Lancini, Andrea Maccarinelli, Samuele Manzoni, Mario Restori, Matteo Rota, Daniela Ruffini, Andrea Verzeletti, Adelaide Conti Abstract Introduction: This study evaluates the assessment protocol that allows the correlation between the development of mesothelioma to a specific exposure, with particular focus on investigations…
Read MoreComparison of 3 Randomized Clinical Trials of Frontline Therapies for Malignant Pleural Mesothelioma
JAMA Network Open 2022 March 1 [Link] Tomer Meirson, Francesca Pentimalli, Francesco Cerza, Giovanni Baglio, Steven G Gray, Pierpaolo Correale, Marija Krstic-Demonacos, Gal Markel, Antonio Giordano, David Bomze, Luciano Mutti Abstract Importance: Some recently proposed frontline therapies for malignant pleural mesothelioma (MPM) are very costly, yet their impact on quality of life and overall survival…
Read MoreThe experience of living with mesothelioma: A meta-ethnographic review and synthesis of the qualitative literature
Health Psychology 2022 February 24 [Link] Benjamin Lond, Kerry Quincey, Lindsay Apps, Liz Darlison, Iain Williamson Abstract Objective: Mesothelioma is a life limiting cancer caused by previous exposure to asbestos. Due to the continued use of asbestos products internationally, the condition presents an increasing risk to global health with case numbers peaking in industrially developed…
Read MoreAsbestos-induced mesothelial injury and carcinogenesis: Involvement of iron and reactive oxygen species
Pathology International 2021 December 29 [Link] Yasumasa Okazaki Abstract Asbestos fibers have been used as an industrial and construction material worldwide due to their high durability and low production cost. Commercial usage of asbestos is currently prohibited in Japan; however, the risk of asbestos-induced malignant mesothelioma (MM) remains. According to epidemiological data, the onset of…
Read MoreImmunotherapy, the promise for present and future of malignant pleural mesothelioma (MPM) treatment
Therapeutic Advances In Medical Oncology 2021 December 10 [Link] Valérie Gounant, Solenn Brosseau, Gérard Zalcman Abstract Due to occupational asbestosis exposure, the incidence of malignant pleural mesothelioma (MPM) has continuously increased over the last 30 years, with a plateau anticipated around the year 2030 in Western countries. Molecular MPM carcinogenesis involves alterations of NF2, RASSF1,…
Read MoreLipid profiling in malignant mesothelioma reveals promising signatures for diagnosis and prognosis: A plasma-based LC-MS lipidomics study
Clinica Chimica Acta 2022 January 1 [Link] Zhongjian Chen, Siyu Song, Chenxi Yang, Ziyi Dai, Yun Gao, Na Li, Jing Zhu, Weimin Mao, Junping Liu Abstract Background and aim: Malignant mesothelioma (MM), being a rare and aggressive carcinoma, can barely be cured. Incidence of this cancer will keep climbing up in the next few decades…
Read MoreBAP1 forms a trimer with HMGB1 and HDAC1 that modulates gene × environment interaction with asbestos
Proceeding of the National Academy of Sciences of the United States of America 2021 November 30 [Link] Flavia Novelli, Angela Bononi, Qian Wang, Fang Bai, Simone Patergnani, Franz Kricek, Ellinor Haglund, Joelle S Suarez, Mika Tanji, Ronghui Xu, Yasutaka Takanishi, Michael Minaai, Sandra Pastorino, Paul Morris, Greg Sakamoto, Harvey I Pass, Haithem Barbour, Giovanni Gaudino,…
Read MoreThe Rarest of the Rare: A Case of BAP1-Mutated Primary Peritoneal Mesothelioma
Cureus 2021 September 29 [Link] Aanchal Gupta, Alisa Vasileva, Sukesh Manthri Abstract Malignant mesotheliomas (MM), as described are rare tumors that are mostly associated with occupational exposure to asbestos. They most commonly occur in the pleura. Other unfamiliar sites where they can occur are the peritoneum, pericardium, and tunica vaginalis. There is no significant correlation…
Read MoreMatrix Metalloproteinases as Biomarkers and Treatment Targets in Mesothelioma: A Systematic Review
Biomolecules 2021 August 25 [Link] Danijela Štrbac, Vita Dolžan Abstract Metalloproteinases (MMPs) have an important role in tissue remodeling and have been shown to have an effect on tumor progression, invasion, metastasis formation, and apoptosis in several tumors, including mesothelioma. Mesothelioma is a rare tumor arising from pleura and peritoneum and is frequently associated with…
Read MoreEnvironmental asbestos exposure and clustering of malignant mesothelioma in community: a spatial analysis in a population-based case-control study
Environmental Health 2021 September 15 [Link] C Airoldi, C Magnani, F Lazzarato, D Mirabelli, S Tunesi, D Ferrante Abstract Background: Neighborhood exposure to asbestos increases the risk of developing malignant mesothelioma (MM) in residents who live near asbestos mines and asbestos product plants. The area of Casale Monferrato (Northwest Italy) was impacted by several sources…
Read More