CONCLUSIONS: Our lung sparing approach for the treatment of pleural mesothelioma in early stages allows promising long term outcomes with a complete sparing of pulmonary and diaphragmatic function. Larger studies are needed to confirm our good results.
March 12, 2017
Comments Off on Is less also better? A single-institution experience on treatment of early stage Malignant Pleural Mesothelioma.
CONCLUSIONS: The CONUT score was an independent predictor of a poor prognosis in the patients with MPM. This score provides useful information for selecting patients who will benefit from the treatment.
March 11, 2017
Comments Off on The Controlling Nutritional Status Score Is a Significant Independent Predictor of Poor Prognosis in Patients With Malignant Pleural Mesothelioma
Differences in survival based on the T, but N stage, were not statistically significant. CONCLUSIONS: The percentage of epithelioid differentiation is an independent predictor of survival in MPM and should be taken into careful consideration when recommending surgical treatment for patients with biphasic MPM.
March 10, 2017
Comments Off on Amount of Epithelioid Differentiation Is a Predictor of Survival in Malignant Pleural Mesothelioma
Of particular interest is the overall survival being approximately triple the disease-free survival, perhaps PDT related. The impact of PDT is unclear, but it is hoped that it will be established by an ongoing randomized trial.
March 9, 2017
Comments Off on Extended Pleurectomy-Decortication-Based Treatment for Advanced Stage Epithelial Mesothelioma Yielding a Median Survival of Nearly Three Years
CONCLUSIONS: The time course of Δ SMRP and Δ vimentin was strongly associated with disease status, and so was the time course of pOPN, albeit to a lesser extent. These markers appear to be particularly effective in cases of partial response and disease progression, while their possible use in stable disease should be better investigated.
March 8, 2017
Comments Off on Serum mesothelin, osteopontin and vimentin: useful markers for clinical monitoring of malignant pleural mesothelioma
In this study we propose a novel approach based on the combination of light distribution modeling with spatial localization of the light applicator for real time estimation and display of the applied dose on medical images. The feasibility approach is demonstrated for intrapleural PDT of malignant pleural mesothelioma.
March 7, 2017
Comments Off on Real-time light dosimetry for intra-cavity photodynamic therapy: Application for pleural mesothelioma treatment
Results of recent clinical studies of immune checkpoint inhibitors in malignant pleural mesothelioma (MPM) have dampened initial enthusiasm. However, the immune environment and targets of these treatments such as program cell death protein 1 (PD-1) and its ligand PD-L1 have not been well characterised in MPM. Using a large cohort of patients, we investigated PD-L1 expression, immune infiltrates and genome-wide copy number status and correlated them to clinicopathological features. PATIENTS AND METHODS:
March 6, 2017
Comments Off on The Immune Microenvironment, Genome -Wide Copy Number Aberrations and Survival in Mesothelioma
Criticism and perspective of this treatment are also discussed. Biological and clinical considerations rule out the use of tremelimumab as single agent for MM and, more generally, the use of immune checkpoint inhibitors for MM is still largely questionable and not supported by evidences.
March 5, 2017
Comments Off on Anti-CTLA-4 therapy for malignant mesothelioma
According to evidence available at present, chrysotile asbestos was the type of asbestos used in dental tape in the past in the United States, and the described cases followed relatively brief and intermittent exposure to this type of asbestos. These cases underscore the need for comprehensive exposure histories to determine exposure scenarios.
March 4, 2017
Comments Off on Malignant mesothelioma due to asbestos exposure in dental tape
From Group A, patients with visceral pleural invasion were 120 (75%) while only 49 patients (38. 5%) were found from Group B and the difference was statistically significant (p.
March 3, 2017
Comments Off on Positive pleural cytology is an indicator for visceral pleural invasion in metastatic pleural effusions