MesotheliomaCenter's

Mesothelioma-Line

Curated Journal Articles on Mesothelioma

Immunotherapy strategies for mesothelioma – the role of tumor specific neoantigens in a new era of precision medicine.

Neoantigen vaccines provide a potential complementary therapeutic strategy by increasing the immunogenic antigen load, which can lead to an increased tumor specific immune response. Further research is needed explore this treatment option in mesothelioma and technological advances are required to translate this concept into clinical practice.
Comments Off on Immunotherapy strategies for mesothelioma – the role of tumor specific neoantigens in a new era of precision medicine.

Treatment and Outcomes of Primary Pericardial Mesothelioma: A Contemporary Review of 103 Published Cases.

PPM remains a rare and poorly understood malignancy with unclear etiology and a poor prognosis. In this retrospective systematic review, a survival benefit was seen in patients who received chemotherapy.
Comments Off on Treatment and Outcomes of Primary Pericardial Mesothelioma: A Contemporary Review of 103 Published Cases.

Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma.

Splicing modulators markedly impair cancer cell viability, resulting also in potent antitumor activity in vivo. Our data designate splicing as a promising therapeutic target in DMPM.
Comments Off on Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma.

The effect of rapid infusion of cisplatin on nephrotoxicity in patients with lung carcinoma.

WHAT IS NEW AND CONCLUSION: The incidence of nephrotoxicity after repeated infusion of cisplatin was not affected by the infusion rate of cisplatin. Therefore, a 1-hour infusion of cisplatin is a safe and feasible method, which may potentially shorten duration of hospital admittance and enable treating patients in the outpatient setting.
Comments Off on The effect of rapid infusion of cisplatin on nephrotoxicity in patients with lung carcinoma.

Pleural thickness after neoadjuvant chemotherapy is a prognostic factor in malignant pleural mesothelioma.

52), respectively. CONCLUSIONS: Pleural thickness after NAC was an independent prognostic factor in patients who underwent multimodal treatment.
Comments Off on Pleural thickness after neoadjuvant chemotherapy is a prognostic factor in malignant pleural mesothelioma.

The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy.

An agonist CD40 antibody based immunotherapy was less efficient at promoting tumor regression in elderly mice, which may be due to: (i) failure of elderly CD8+ T cells to up-regulate perforin, and (ii) increased expression of multiple regulatory markers on CD11c+ cells and T cells in elderly tumor-draining lymph nodes (including CD73, PD-1, ICOS, LAG-3, and TGF-β). Our findings suggest that checkpoint blockade may improve responses to immunotherapy in elderly hosts with mesothelioma, and warrants further investigation.
Comments Off on The Regulatory Status Adopted by Lymph Node Dendritic Cells and T Cells During Healthy Aging Is Maintained During Cancer and May Contribute to Reduced Responses to Immunotherapy.

What is Mesothelioma?

Learn more about this fatal cancer, including the causes, symptoms, and treatments for both pleural and peritoneal tumors of the mesothelium at our parent site MesotheliomaCenter.

Biodistribution and Tumor Uptake of 67Ga-Nimotuzumab in a Malignant Pleural Mesothelioma Xenograft.

Biodistribution and tumor uptake imaging studies by microSPECT/CT in mesothelioma xenografts revealed constant nimotuzumab uptake at the tumor site during the first 48 h after drug administration. In vivo studies using MPM xenografts showed a significant uptake of this radioimmunoconjugate, which illustrates its potential as a biomarker that could promote its theranostic use in patients with MPM.
Comments Off on Biodistribution and Tumor Uptake of 67Ga-Nimotuzumab in a Malignant Pleural Mesothelioma Xenograft.

Tumour associated lymphocytes in the pleural effusions of patients with mesothelioma express high levels of inhibitory receptors.

RESULTS: Both CD8+ and CD4+ T cells from effusion showed increased expression of T cell inhibitory receptors PD-1, LAG-3 and Tim-3 compared to blood. Comprehensive T cell receptor sequencing on one of the patients showed a discordant distribution of clonotypes in the antigen-experienced (PD-1+) compartment between effusion and blood, suggesting an enrichment of antigen specific clonotypes in the effusion, with potential as an immunological response biomarker.
Comments Off on Tumour associated lymphocytes in the pleural effusions of patients with mesothelioma express high levels of inhibitory receptors.

The role of BRCA1-associated protein 1 in the diagnosis of malignant mesothelioma in effusion and fine-needle aspiration cytology.

RESULTS: Of the 26 MM cases, a slight majority (14/26, 54%) showed loss of BAP1 nuclear IHC staining, while all 13 RMC controls showed strong nuclear BAP1 IHC staining. MM was more likely to show loss of BAP1 than RMC (P.
Comments Off on The role of BRCA1-associated protein 1 in the diagnosis of malignant mesothelioma in effusion and fine-needle aspiration cytology.

Management of database: European Society of Thoracic Surgeons mesothelioma database-difficulties in improving quality data for rare tumour.

CONCLUSIONS: The ESTS database represents one of the largest mesothelioma database comprehensive of clinical, surgical and follow up data. The main issue with such an detailed database is the completeness of the data entry, which is crucial to better understand the impact of surgery and monitor the quality of surgery offered across the centres.
Comments Off on Management of database: European Society of Thoracic Surgeons mesothelioma database-difficulties in improving quality data for rare tumour.