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Journal of Surgical Oncology. 2008 Sep 15;98(4):258-62. [Link] Baratti D, Kusamura S, Deraco M. Department of Surgery, National Cancer Institute, Milan, Italy. Abstract Peritoneal surface malignancies (PSM) have been traditionally…
Journal of Surgical Oncology. 2008 Sep 15;98(4):268-72. [Link] Deraco M, Bartlett D, Kusamura S, Baratti D. Department of Surgery, National Cancer Institute, Milan, Italy. marcello.deraco@istitutotumori.mi.it Abstract Diffuse malignant peritoneal mesothelioma…
British Journal of Cancer. 2008 Sep 2;99(5):822-9. Epub 2008 Aug 19. [Link] Frost G, Harding AH, Darnton A, McElvenny D, Morgan D. Health & Safety Laboratory, Harpur Hill, Buxton, Derbyshire…
Therapeutics and Clinical Risk Management. 2008 Feb;4(1):205-11. [Link]
Goudar RK.
Department of Medicine, Division of Hematology, Medical Oncology and Cellular Therapy, Duke University Medical Center, Durham, NC, USA.
Abstract
Malignant pleural mesothelioma is a resistant form of lung cancer, and its incidence continues to rise in Europe and Australia. Until recently, chemotherapy had not been shown to be effective in the treatment of this slowly progressive disease. In 2004, the combination of pemetrexed and cisplatin was shown to induce high response rates in MPM. This article reviews the published literature describing the development and testing of this therapeutic combination in mesothelioma, and examines in detail the key phase III clinical trial that led to the approval of pemetrexed by the US FDA. Ongoing research will further define the role of pemetrexed plus cisplatin in the treatment of MPM.
Keywords: malignant pleural mesothelioma, mesothelioma, pemetrexed, cisplatin
Therapeutics and Clinical Risk Management. 2008 Feb;4(1):205-11. [Link] Goudar RK. Department of Medicine, Division of Hematology, Medical Oncology and Cellular Therapy, Duke University Medical Center, Durham, NC, USA. Abstract Malignant…
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