Subarachnoid-pleural fistula as a complication of malignant pleural mesothelioma

Respirology. 2006 Jul;11(4):502-5. [Link]

Christoph M. Heyer,1 Anja Theile,2 Heike Weisser,3 Joseph Reichert,4 Christoph Horch,5 Klaus-M. Mueller2 and Torsten T. Bauer6

1Institute of Diagnostic Radiology, Interventional Radiology and Nuclear Medicine,
2Institute of Pathology,
Institute of Clinical Chemistry, Transfusion Medicine and Laboratory Medicine,
Department of Thoracic Surgery,
Department of Traumatology, Neurotraumatology and Spinal Cord Injuries, and
6Medical Clinic III, Pneumology, Allergology, and Sleep Medicine, BG Clinics ‘Bergmannsheil’, Ruhr-University of Bochum, Bochum, Germany


We report a 62-year-old male patient with asbestos-related malignant pleural mesothelioma who developed recurrent pleural effusions after surgical resection of paravertebral tumour masses. Pleural effusions were drained on several occasions with the patient suffering severe headaches and vascular dysregulation. Cytological studies of the pleural fluid showed no evidence of inflammatory or malignant cells. The fluid was interpreted as seroma despite its unusual transparency until magnetic resonance imaging was suggestive of a subarachnoid-pleural fistula; its presence was confirmed when beta-trace protein—a specific marker for cerebrospinal fluid—was added to the standard laboratory testing of the pleural effusion. A subarachnoid-pleural fistula has to be included in the differential diagnosis of patients with recurrent pleural effusions after surgical debulkment of malignant pleural mesothelioma. The beta-trace protein may help to establish this diagnosis especially in cases where important therapeutic consequences may need to be drawn.