Radiation Injury to the Liver After Intensity-Modulated Radiation Therapy in Patients with Mesothelioma: An Unusual CT Appearance

American Journal of Roentgenology 184, no. 4 (2005): 1091-1095. http://www.ajronline.org/cgi/content/abstract/184/4/1091

Reginald F. Munden1, Jeremy J. Erasmus1, William R. Smythe2, John E. Madewell1, Kenneth M. Forster3 and Craig W. Stevens3

  1. Division of Diagnostic Imaging, Department of Diagnostic Radiology, The University of Texas M.D. Anderson Cancer Center, Box 57, 1515 Holcombe Blvd., Houston, TX 77030.
  2. Department of Surgery, The Texas A ∓ M University System, Health Science Center, Temple, TX 76508.
  3. Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030


Objective: We sought to report the unusual distribution of radiation-induced injury to the liver in patients with mesothelioma after extrapleural pneumonectomy and intensity-modulated radiation therapy (IMRT).

Conclusion: Abnormal hepatic enhancement after extrapleural pneumonectomy and IMRT is common in patients with mesothelioma. Knowledge of the early occurrence and typical location and appearance of IMRT-induced injury can be useful in preventing misinterpretation as metastatic disease or recurrent tumor.