Management of malignant mesothelioma by decortication and adjunct phototherapy

Asian Cardiovascular and Thoracic Annals. 2006 Jun;14(3):206-9. [Link]

Charles P Clarke, MBBS, Simon R Knight, MBBS, Freddy J Daniel, MBMS, Siven Seevanayagam, MBBS

Austin Health, Heidelberg, Victoria, Australia

For reprint information contact: CP Clarke, MBBS Tel: 61 3 9419 2477 Fax: 61 3 9417 1694 Email:


Malignant mesothelioma is a relatively rare tumor that originates in the pleural space and almost invariably results from exposure to asbestos. Between September 1989 and December 1999, 100 patients were managed with curative intent using a combination of full decortication, adjunct phototherapy after administration of hematoporphyrin derivative, and strip radiotherapy to any areas where adequate clearance was not obtained. The survival curve was compared to that of 17 matched patients treated by decortication alone. Median survival increased from 250 to 440 days in the combined treatment group.