Journal of Cutaneous Pathology. 2008 Jan;35(1):70-3. [Epub ahead of print] [Link]
Barresi V, Vitarelli E, Barresi G.
Dipartimento di Patologia Umana, Policlinico Universitario G. Martino, University of Messina, Italy.
Diffuse malignant peritoneal mesothelioma (DMPM) is a relatively rare neoplasm. Risk factors associated with its development include asbestos exposure, chronic irritation or inflammation of the peritoneum, abdominal radiotherapy, familial Mediterranean fever and simian virus 40. A familial segregation of this neoplasia has been reported in small villages of the Cappadocian region of Turkey, and it has been postulated that hereditary factors may predispose to mesothelioma, even with exposure to small amounts of asbestos. We report a case of DMPM, which apparently occurred in the absence of predisposing factors in a patient with a clinical history characterized by recurrent pre-sacral acne inversa of long duration. The association of this chronic inflammatory disease with DMPM has never been reported. The genetic locus for acne inversa has recently been identified within the 1p21.1â€“1q25.3 chromosomal region. Interestingly, frequent losses in chromosomal region 1p.21â€“22 have been found in mesothelioma as well. It is thus tempting to speculate that genetic mutations involving chromosome 1p.21â€“22 may account for the development of both diseases.