Expression of stathmin in asbestos-like fibers-induced mesothelioma: A preliminary report

Histology and Histopathology 2023 June 30 [Link]

Claudia Lombardo, Giuseppe Broggi, Ermanno Vitale, Caterina Ledda, Carla Loreto, Serena Matera, Maria Hagnas, Rosario Caltabiano, Veronica Filetti


Background: Mesothelioma is strongly associated with exposure to asbestos fibers, however, recent studies have also linked exposure to “naturally occurring asbestos” fibers with this disease. Fluoro-edenite, a silicate mineral found in the southeast of Biancavilla (Sicily, Italy), has been identified as a potential risk factor for mesothelioma. Unfortunately, this cancer often has a poor prognosis, and current diagnostic and prognostic biomarkers are inadequate. Histological subtype, gender, and age at diagnosis are the most significant parameters for mesothelioma. Stathmin, a cytosolic protein that regulates cell growth and migration and is overexpressed in many human malignancies, has not yet been linked to mesothelioma survival or clinical-pathological variables.

Aim: The aim of this study was to investigate the immunohistochemical expression of stathmin in ten mesothelioma tissue samples with available clinical and follow-up data.

Material and methods: Paraffin-embedded tissue samples from ten mesothelioma patients were processed for immunohistochemical analyses to evaluate stathmin expression.

Results: Our findings suggest that stathmin overexpression is associated with shorter overall survival in patients with mesothelioma. Furthermore, stathmin expression was significantly correlated with the survival time of mesothelioma patients.

Conclusion: Our results suggest that stathmin expression may serve as a potential prognostic biomarker for mesothelioma. This biomarker could be used to promptly identify patients with poor prognosis and to guide clinicians in the selection of treatment options.