Single walled carbon nanotubes (SWCNT) affect cell physiology and cell architecture

November 9, 2007

Journal of Materials Science: Materials in Medicine. 2007 Nov 8 [Epub ahead of print] [Link]

Kaiser JP, Wick P, Manser P, Spohn P, Bruinink A.

Materials – Biology Interactions Laboratory, Materials Science and Technology (Empa), Lerchenfeldstrasse 5, St. Gallen, CH-9014, Switzerland, jean-pierre.kaiser@empa.ch.

Abstract

Single walled carbon nanotubes (SWCNT) find their way in various industrial applications. Due to the expected increased production of various carbon nanotubes and nanoparticle containing products, exposure to engineered nanoparticles will also increase dramatically in parallel. In this study the effects of SWCNT raw material and purified SWCNT (SWCNT bundles) on cell behaviour of mesothelioma cells (MSTO-211H) and on epithelial cells (A549) had been investigated. The effect on cell behaviour (cell proliferation, cell activity, cytoskeleton organization, apoptosis and cell adhesion) were dependent on cell type, SWCNT quality (purified or not) and SWCNT concentration.

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