Lung Cancer. 2007 Oct 3; [Epub ahead of print] [Link]

Razak AR, Chatten KJ, Hughes AN.

Medical Oncology Department, Northern Centre for Cancer Treatment, Newcastle General Hospital, Newcastle upon Tyne NE4 9XF, United Kingdom.


The role of second line treatment in malignant pleural mesothelioma (MPM) is currently undefined. We present four cases of patients who had durable responses from pemetrexed-based chemotherapy who were retreated with a similar regimen upon progression of their mesothelioma. This case series explores the possible role of retreatment with pemetrexed-based chemotherapy as a second line therapeutic option in MPM.

Keywords: Mesothelioma; Pemetrexed; Second line; Retreatment; Chemotherapy; response