Nodular glomeruloid pleuroblastoma: a biphasic pleural-based malignant tumor with immature elements

Virchows Archiv. 2006 Jun 1; [Epub ahead of print] [Link]

Pinias Mukonoweshuro1, Richard L. Attanoos2 and Mark E. F. Smith1

(1) Department of Histopathology, Level 04, Derriford Hospital, Derriford Road, Plymouth, PL6 8DH, UK
(2) Department of Histopathology, Llandough Hospital, Penlan Road, Llandough, Penarth, Vale of Glamorgan, CF64 2XX Wales, UK

Received: 23 October 2005 Accepted: 24 April 2006 Published online: 1 June 2006


An unusual diffuse pleural-based tumor arising in an elderly asbestos-exposed male is presented. The tumor presented in a 72-year-old male with a 30-year history of dockyard work and likely significant asbestos exposure. Macroscopically, at post mortem, the pleural tumor diffusely encased the right lung and was composed of an admixture of neoplastic macro-, and by light microscopy, micro-nodules. Histologically, the tumor had a biphasic growth pattern with glomeruloid epithelioid elements and immature blastematous mesenchymal stroma. Immunophenotypically, the tumor had a complex pattern with epithelioid elements expressing cytokeratins, desmin, carcinoembryonic antigen (CEA), Ber EP4 and E-cadherin. The diagnostic problems and medicolegal issues surrounding the diagnosis and differentiation from malignant pleural mesothelioma and other tumors are discussed.