Applied Immunohistochemistry & Molecular Morphology. 2008 Jun 20. [Epub ahead of print] [Link]

Lester T, Xu H.

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY.


Malignant mesotheliomas occur in the pleura, peritoneum, pericardium, and tunica vaginalis. The majority of tumors are pleural in origin. The typical pattern of spread is usually contiguous or via implantation. Hematogenous or lymphatic metastasis is not uncommon; however, metastasis to bone has rarely been well documented. This is a case report of malignant pleural mesothelioma metastatic to the femur with a pathologic fracture of femoral neck.