Autocrine growth by granulocyte colony-stimulating factor in malignant mesothelioma

The Annals of Thoracic Surgery. Volume 82, Issue 5, November 2006, Pages 1904-1906 [Link]

Motohiro Nishimura MD, PhDa, Kyoko Itoh MD, PhDb, Kazuhiro Ito MD, PhDa, Masashi Yanada MDa, Kunihiko Terauchi MDa, Shinji Fushiki MD, PhDb and Junichi Shimada MD, PhDa

aDepartment of Thoracic Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
bDepartment of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Accepted 2 February 2006.  Available online 22 October 2006.


We report the first case of a malignant mesothelioma expressing not
only granulocyte-colony stimulating factor (G-CSF), but also its
receptor. A 59-year-old male carpenter underwent a
panpleuropneumonectomy, but the tumor relapsed and spread rapidly,
accompanied by leukocytosis. The white blood cell count reached
147,000/mm3 (96.2% neutrophils), and the concentration of serum G-CSF was 77 pg/mL. An autopsy demonstrated that some of the tumor cells produced G-CSF, but more tumor cells and endothelial cells in the tumor expressed G-CSF receptor. It was hypothesized that an autocrine loop involving G-CSF and the G-CSF receptor greatly accelerated the tumor growth.