Pathology 2021 May 6 [Link] Fabien Forest, David Laville, Cyril Habougit, Margot Corbasson, Sophie Bayle-Bleuez, Claire Tissot, Pierre Fournel, Olivier Tiffet, Michel Péoc’h Abstract The prognostic impact of tumour grading, cytological and architectural patterns and stromal features in diffuse pleural malignant epithelioid mesothelioma (MEM) has been partly studied but not correlated to molecular features. We…

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Lung Cancer 2021 June [Link] Frédéric Larose, Nicholas Quigley, Yves Lacasse, Simon Martel, Loïc Lang-Lazdunski Abstract Objectives: Medical management based on palliative chemotherapy is currently the standard of care in malignant pleural mesothelioma (MPM). Median survival of 12-16 months has been reported with modern chemotherapy regimens with or without anti-angiogenic agents. Multimodality therapy incorporating cytoreductive…

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Interactive Cardiovascular and Thoracic Surgery 2021 May 8 [Link] Toru Nakamichi, Masaki Hashimoto, Akifumi Nakamura, Ayumi Kuroda, Takashi Tanaka, Jiro Takeuchi, Seiji Matsumoto, Takeshi Morimoto, Nobuyuki Kondo, Kazuhisa Domen, Seiki Hasegawa Abstract Objectives: Impact of pleurectomy/decortication (P/D) on quality of life (QOL) is not widely reported. We investigated QOL and lung function after P/D. Methods:…

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Frontiers in Oncology 2021 April 20 [Link] Oscar Arrieta, Wendy Muñoz-Montaño, Sae Muñiz-Hernández, Saul Campos, Rodrigo Catalán, Herman Soto-Molina, Silvia Guzmán Vázquez, Osvaldo Díaz-Álvarez, Victor Martínez-Pacheco, Jenny G Turcott, Maritza Ramos-Ramírez, Luis Cabrera-Miranda, Feliciano Barrón, Andrés F Cardona Abstract Background: Malignant pleural mesothelioma (MPM) is rare and aggressive neoplasia, with a poor prognosis; furthermore, the…

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BMC Pulmonary Medicine 2021 May 5 [Link] Steven G Gray Abstract Background: The role of immunotherapy in cancer is now well-established, and therapeutic options such as checkpoint inhibitors are increasingly being approved in many cancers such as non-small cell lung cancer (NSCLC). Malignant pleural mesothelioma (MPM) is a rare orphan disease associated with prior exposure…

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Anticancer Research 2021 May [Link] Akihiro Shiroshita, Motohiro Kurosaki, Masafumi Takeshita, Yuki Kataoka Abstract Background/aim: Although surgical thoracoscopy is recommended in the diagnosis of malignant pleural mesothelioma (MPM), the invasiveness of this procedure is of strong concern. Our review aimed to evaluate the accuracies of medical thoracoscopy (MT), computed tomography (CT)-guided biopsy, and ultrasound (US)-guided…

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The Journal of Pathology. Clinical Research 2021 May 6 [Link] Hely Ollila, Juuso Paajanen, Henrik Wolff, Ilkka Ilonen, Eva Sutinen, Katja Välimäki, Arne Östman, Sisko Anttila, Eeva Kettunen, Jari Räsänen, Olli Kallioniemi, Marjukka Myllärniemi, Mikko I Mäyränpää, Teijo Pellinen Abstract Malignant pleural mesothelioma (MPM) has a rich stromal component containing mesenchymal fibroblasts. However, the properties…

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International Journal of Molecular Medicine 2021 June [Link] Silvana Pinelli, Rossella Alinovi, Diana Poli, Massimo Corradi, Giorgio Pelosi, Marcello Tiseo, Matteo Goldoni, Delia Cavallo, Paola Mozzoni Abstract Dysregulated levels of microRNAs (miRNAs or miRs), involved in oncogenic pathways, have been proposed to contribute to the aggressiveness of malignant pleural mesothelioma (MPM). Previous studies have highlighted…

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EMBO Molecular Medicine 2021 May 6 [Link] Rosanna Mezzapelle, Francesco De Marchis, Chiara Passera, Manuela Leo, Francesca Brambilla, Federica Colombo, Maura Casalgrandi, Alessandro Preti, Samuel Zambrano, Patrizia Castellani, Riccardo Ertassi, Marco Silingardi, Francesca Caprioglio, Veronica Basso, Renzo Boldorini, Angelo Carretta, Francesca Sanvito, Ottavio Rena, Anna Rubartelli, Lina Sabatino, Anna Mondino, Massimo P Crippa, Vittorio Colantuoni,…

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