Connective Tissue Research. 2008;49(3):270-2. [Link]

Dobra K, Hjerpe A.

Department of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Stockholm, Sweden.


Malignant Mesothelioma presents with a characteristic heterogeneous growth pattern. Response to treatment is often only partial, which may be related to tumor cell heterogeneity. Molecular screening methods have revealed profound differences in the driving mechanisms of the variously differentiated mesothelioma cells. Characterization of these differences has made it possible to identify novel drug targets which are effective for both phenotypes.