SV40 enhances the risk of malignant mesothelioma among people exposed to asbestos: a molecular epidemiologic case-control study

Cancer Research 65, No. 8 (2005): 3049-3052.

Alfonso Cristaudo1, Rudy Foddis1, Agnese Vivaldi1, Rodolfo Buselli1, Vittorio Gattini1, Giovanni Guglielmi1, Francesca Cosentino1, Franco Ottenga1, Eugenio Ciancia2, Roberta Libener3, Rosangela Filiberti4, Monica Neri4, PierGiacomo Betta3, Mauro Tognon5, Luciano Mutti6,7 and Riccardo Puntoni4

  1. Department of Endocrinology and Metabolism, Orthopedic and Traumatology, Occupational Medicine, University of Pisa;
  2. Pathologic Anatomy Service, S.Chiara Hospital, Pisa, Italy;
  3. Pathology Unit, Department of Oncology, Azienda Sanitaria Ospedaliera, Alessandria, Italy;
  4. National Cancer Research Institute, Unit of Environmental Epidemiology, Genoa, Italy;
  5. Section of Histology and Embryology,Department of Morphology and Embryology, University of Ferrara, Ferrara, Italy;
  6. S.Pietro e Paolo Hospital, Borgosesia, Italy; and
  7. S.Maugeri Foundation Institute for Research and Care, Pavia, Italy


We conducted a case-control study on asbestos exposure and presence of SV40 in tumor samples of malignant mesotheliomas (MMs) and bladder urotheliomas (BUs). PCR analysis revealed the presence of SV40 DNA (SV40+) in eight (42.1%) MMs and 6 (33.3%) BUs. The odds ratio for MM Asb– and SV40+ was 0.4 [95% confidence interval (95% CI), 0.03-4.0], for Asb+ and SV40– was 3.6 (95% CI, 0.6-21.0), and for Asb+ and SV40+ was 12.6 (95% CI, 1.2-133.9). Our results suggest that SV40 increases the risk of MM among individuals exposed to asbestos.