Positive TTF-1 Expression in Malignant Mesothelioma: A Case Report

The American Journal of Case Reports 2016 March [Link]

Richter G, Heidersdorf H, Hirschfeld D, Krebbel F.



The histopathological diagnosis of malignant mesothelioma is based mainly on the immunohistological profile of the neoplasia, using different immunohistochemical markers to distinguish between a malignant mesothelioma and a carcinoma.

Case Report

A female patient presented with a right paravertebral rapidly growing tumor and severe pain. Based on the immunohistochemical findings, we present the first case of a malignant mesothelioma with immunohistochemical expression of thyroid transcription factor-1.


The detection of a positive reaction for thyroid transcription factor-1 in the tumor cells may not exclude a malignant mesothelioma.