High Expression of PEA15 Is Associated With Patient Survival in Malignant Pleural Mesothelioma

Cancer Diagnosis and Prognosis 2021 July 3 [Link]

Shajedul Islam, Takao Kitagawa, Yasuhiro Kuramitsu


Background/aim: Malignant pleural mesothelioma (MPM) is a rare but very aggressive tumor that is primarily pleural in origin. The 5-year overall survival rate of patients with MPM has not improved despite therapeutic advances. Therefore, biomarker discovery to identify premalignant or early malignant tumors of the mesothelium are crucial. PEA15 is a cytoplasmic protein that is involved in various human malignancies, including MPM. However, the clinicopathological involvement of PEA15 in MPM has not yet been documented.

Materials and methods: The Oncomine database and GEPIA2 platform were used to analyze PEA15 mRNA expression and patient survival in patients with MPM.

Results: PEA15 was found to be significantly up-regulated in MPM, and this up-regulation inversely correlated with prolonged patient survival. Further, PEA15 expression was found to be increased in other cancer tissues without affecting overall survival.

Conclusion: PEA15 may represent a new potential prognostic biomarker in MPM patients.