Bulletin of Experimental Biology and Medicine. 2006 Mar;141(3):353-6. [Link]

Kobliakov VA, Vaiman AV, Pylev LN, Vasil’eva LA.

Institute of Carcinogenesis, Russian Academy of Medical Sciences, Moscow. vakob@crc.umos.ru


Expression of mRNA for the mdr1 gene, cytochrome P450 isoforms 1A1 and 1B1, Ah receptor, and ARNT protein regulating the concentration of cytochrome P450 mRNA was compared in normal and spontaneously transformed mesothelial cells and mesothelioma cells from rats. Expression of cytochrome P450 1A1 and 1B1 mRNA decreased in transformed mesothelial and mesothelioma cells compared to normal mesothelial cells. mRNA for the mdr1 gene was undetected in normal mesothelial cells. Expression of mRNA for the Ah receptor and ARNT protein did not differ in cultured cells.