Clinical Lung Cancer 2020 June 14 [Link]

Akash Patel, Leonid Roshkovan, Sally McNulty, Evan Alley, Drew A Torigian, Arun C Nachiappan, Maya Galperin-Aizenberg, Eduardo M Barbosa Jr, Joseph DiRienzi, Ian Berger, Urooj Khalid, Andrew R Haas, Sunil Singhal, E Paul Wileyto, Keith A Cengel, Sharyn I Katz


Background: Radiologic assessment of malignant pleural mesothelioma (MPM) on computed tomography (CT) imaging can be limited by similar attenuations of MPM and adjacent tissues. This can result in inaccuracies in defining the presence and extent of pleural tumor burden. We hypothesized that increasing the time delay for pleural enhancement will optimize discrimination between MPM and noncancerous tissues on CT. Here we conduct a prospective observational study to determine the optimal time delay for imaging MPM on CT.

Patients and methods: Adult MPM patients (n = 15) were enrolled in this prospective exploratory imaging trial. Patients with < 1 cm MPM thickness, prior pleurectomy, pleurodesis, pleural radiotherapy, or antiangiogenic therapy were excluded. All patients underwent a dynamically-enhanced CT with multiple time delays (0 – 10 minutes) after intravenous contrast administration. Tumor tissue attenuation was measured at each phase of enhancement. A qualitative assessment of tumor enhancement kinetics was also performed. The optimal phase of enhancement based on qualitative lesion conspicuity and quantitative tumor enhancement was then compared.

Results: MPM tumor enhancement was quantitatively and qualitatively increased at time delays beyond the conventional time delay for thoracic CT imaging (40-60 seconds). Patient tumor enhancement kinetics, displayed as the fraction of maximal tumor tissue attenuation as a function of time, revealed an optimal time delay of 230 to 300 seconds after intravenous contrast administration. There was an association between degree of tumor enhancement and subjective lesion conspicuity.

Conclusion: Optimal MPM contrast enhancement occurs at a later phase than typically acquired with conventional thoracic CT imaging.