High Expression of SMO and GLI1 Genes with Poor Prognosis in Malignant Mesothelioma

Biomed Research International 2023 April 24 [Link] Guan-Ying Ma, Shuai Shi, Yin-Zhou Sang, Ping Wang, Zhi-Gang Zhang Abstract Background: To investigate the value of SMO and GLI1 genes in the hedgehog pathway in malignant mesothelioma specimens. Further study on the expression and prognosis of SMO and GLI1 in malignant mesothelioma tissues and the relationship between…

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ATG5 as biomarker for early detection of malignant mesothelioma

BMC Research Notes 2023 April 24 [Link] Marco Tomasetti, Federica Monaco, Olga Strogovets, Luca Volpini, Matteo Valentino, Monica Amati, Jiri Neuzil, Lory Santarelli Abstract Objectives: Malignant pleural mesothelioma (MPM) is an aggressive disease with grim prognosis due to lack of effective treatment options. Disease prediction in association with early diagnosis may both contribute to improved…

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Epigenetic investigation into circulating microRNA 197-3p in sera from patients affected by malignant pleural mesothelioma and workers ex-exposed to asbestos

Scientific Reports 2023 April 20 [Link] Giulia Di Mauro, Francesca Frontini, Elena Torreggiani, Maria Rosa Iaquinta, Andrea Caselli, Chiara Mazziotta, Valentina Esposito, Elisa Mazzoni, Roberta Libener, Federica Grosso, Antonio Maconi, Fernanda Martini, Ilaria Bononi, Mauro Tognon Abstract The epigenetic role of microRNAs is established at both physiological and pathological levels. Dysregulated miRNAs and their targets…

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One Third of Malignant Pleural Mesothelioma Shows High Immunohistochemical Expression of MSLN or CXCR4 Which Indicates Potent Candidates for Endo-Radiotherapy

International Journal of Molecular Sciences 2023 March 28 [Link] Thomas Hager, Sabrina Borchert, Michael Wessolly, Alexander Mathilakathu, Elena Mairinger, Jens Kollmeier, Thomas Mairinger, Balazs Hegedus, Kristina Greimelmaier, Jeremias Wohlschlaeger, Ken Herrmann, Fabian Dominik Mairinger Abstract Malignant pleural mesothelioma (MPM) is a mainly asbestos-related tumour associated with a very poor prognosis. Therapeutic approaches include multimodal therapy…

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Genetic analysis of familial predisposition in the pathogenesis of malignant pleural mesothelioma

Journal of Cancer Research and Clinical Oncology 2023 April 7 [Link] Muhittin Akarsu, Güntülü Ak, Emine Dündar, Muzaffer Metintaş Abstract Purpose: Mesothelioma is the primary tumor of the mesothelial cell membrane. The most important etiology is asbestos exposure. The development of malignant mesothelioma in very few of the population exposed to asbestos and its frequent…

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Association of mesothelioma deaths with neighborhood asbestos exposure due to a large-scale asbestos-cement plant

Cancer Science 2023 April 3 [Link] Yuri Kitamura, Ling Zha, Rong Liu, Masayuki Shima, Tomoki Nakaya, Norio Kurumatani, Shinji Kumagai, Junko Goji, Tomotaka Sobue Abstract A causal relationship between mesothelioma and occupational asbestos exposure is well known, while some studies have shown a relationship to non-occupational exposures. The aim of this study was to quantify…

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Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model

Environmental Health 2022 December 21 [Link] Kenneth T Bogen Abstract Alterations in complex cellular phenotype each typically involve multistep activation of an ultrasensitive molecular switch (e.g., to adaptively initiate an apoptosis, inflammasome, Nrf2-ARE anti-oxidant, or heat-shock activation pathway) that triggers expression of a suite of target genes while efficiently limiting false-positive switching from a baseline…

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Developing sustainable patient and public involvement in mesothelioma research: multi-method exploration with researchers, patients, carers, and patient organisations

Research Involvement and Engagement 2023 March 25 [Link] Afrodita Marcu, Fiona McGregor, Bernadette Egan, Kate Hill, Tim Cook, Anne Arber Abstract Background: Rare diseases where prognosis is poor provide limited scope for patient and public involvement (PPI). One such disease is mesothelioma, a cancer of the lung pleura or of the peritoneum caused by exposure…

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New pathogenic germline variants identified in mesothelioma

Lung Cancer 2023 March 15 [Link] Laila Belcaid, Birgitte Bertelsen, Karin Wadt, Ida Tuxen, Iben Spanggaard, Martin Højgaard, Jens Benn Sørensen, Jesper Ravn, Ulrik Lassen, Finn Cilius Nielsen, Kristoffer Rohrberg, Christina Westmose Yde Abstract Background: Mesothelioma (MM) is associated with asbestos exposure, tumor heterogeneity and aggressive clinical behavior. Identification of germline pathogenic variants (PVs) in…

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Benefits and Challenges of Inhibiting EZH2 in Malignant Pleural Mesothelioma

Cancers 2023 February 28 [Link] Mhd Ouis Al Khatib, Giulia Pinton, Laura Moro, Chiara Porta Abstract Malignant pleural mesothelioma (MPM) is an aggressive thoracic cancer that is mainly associated with prior exposure to asbestos fibers. Despite being a rare cancer, its global rate is increasing and the prognosis remains extremely poor. Over the last two…

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