Causation
HMGB1 released by mesothelial cells drives the development of asbestos-induced mesothelioma
Proceedings of the National Academy of Sciences of the United States of America 2023 September 26 [Link] Joelle S Suarez, Flavia Novelli, Keisuke Goto, Michiko Ehara, Mika Steele, Jin-Hee Kim, Alicia A Zolondick, Jiaming Xue, Ronghui Xu, Mai Saito, Sandra Pastorino 1, Michael Minaai, Yasutaka Takanishi, Mitsuru Emi, Ian Pagano, Andrew Wakeham, Thorsten Berger, Harvey…
Read MoreFOXM1 Promotes Mesothelioma Cell Migration and Invasion via Activation of SMAD Signaling
Anticancer Research 2023 September [Link] Ihiro Endo, Vishwa Jeet Amatya, Kei Kushitani, Takahiro Kambara, Tetsuya Nakagiri, Kohei Aoe, Yukio Takeshima Abstract Background/aim: Forkhead box M1 (FOXM1) is a transcription factor closely associated with various human malignancies and is considered an attractive target for cancer therapy. Mesothelioma is a malignancy primarily due to asbestos exposure and…
Read MoreJSI-124 inhibits cell proliferation and tumor growth by inducing autophagy and apoptosis in murine malignant mesothelioma
Molecular Carcinogenesis 2023 August 29 [Link] Chengke Zhang, Qifeng Sun, Jiangfeng Zhao, Ning Jiang, Yingtao Hao, Junwen Luo, Saraf Karim, Licun Wu, Marc de Perrot, Chuanliang Peng, Xiaogang Zhao Abstract Malignant pleural mesothelioma (MPM), mainly caused by asbestos exposure, has a poor prognosis and lacks effective treatment compared with other cancer types. The intracellular transcription…
Read MoreChronic Inflammation, Oxidative Stress and Metabolic Plasticity: Three Players Driving the Pro-Tumorigenic Microenvironment in Malignant Mesothelioma
Cells 2023 August 11 [Link] Irene Fiorilla, Simona Martinotti, Alberto Maria Todesco, Gregorio Bonsignore, Maria Cavaletto, Mauro Patrone, Elia Ranzato, Valentina Audrito Abstract Malignant pleural mesothelioma (MPM) is a lethal and rare cancer, even if its incidence has continuously increased all over the world. Asbestos exposure leads to the development of mesothelioma through multiple mechanisms,…
Read MoreAPE-1/Ref-1 Inhibition Blocks Malignant Pleural Mesothelioma Cell Proliferation and Migration: Crosstalk between Oxidative Stress and Epithelial Mesenchymal Transition (EMT) in Driving Carcinogenesis and Metastasis
International Journal of Molecular Sciences 2023 August 8 [Link] Valeria Ramundo, Giada Zanirato, Maria Luisa Palazzo, Chiara Riganti, Elisabetta Aldieri Abstract Malignant pleural mesothelioma (MPM) is an aggressive cancer associated with asbestos exposure. MPM pathogenesis has been related both to oxidative stress, evoked by and in response to asbestos fibers exposure, and epithelial mesenchymal transition…
Read MoreExpression of stathmin in asbestos-like fibers-induced mesothelioma: A preliminary report
Histology and Histopathology 2023 June 30 [Link] Claudia Lombardo, Giuseppe Broggi, Ermanno Vitale, Caterina Ledda, Carla Loreto, Serena Matera, Maria Hagnas, Rosario Caltabiano, Veronica Filetti Abstract Background: Mesothelioma is strongly associated with exposure to asbestos fibers, however, recent studies have also linked exposure to “naturally occurring asbestos” fibers with this disease. Fluoro-edenite, a silicate mineral…
Read MoreAsbestos accelerates disease onset in a genetic model of malignant pleural mesothelioma
Frontiers in Toxicology 2023 June 27 [Link] Pooyeh Farahmand, Katarina Gyuraszova, Claire Rooney, Ximena L Raffo-Iraolagoitia, Geeshath Jayasekera, Ann Hedley, Emma Johnson, Tatyana Chernova, Gaurav Malviya, Holly Hall, Tiziana Monteverde, Kevin Blyth, Rodger Duffin, Leo M Carlin, David Lewis, John Le Quesne, Marion MacFarlane, Daniel J Murphy Abstract Hypothesis: Asbestos-driven inflammation contributes to malignant pleural…
Read MoreMesenchymal stromal cells loaded with Paclitaxel (PacliMES) a potential new therapeutic approach on mesothelioma
Biochemical Pharmacology 2023 August [Link] Valentina Coccè, Mara Bonelli, Silvia La Monica, Roberta Alfieri, Luisa Doneda, Eleonora Martegani, Giulio Alessandri, Costanza Annamaria Lagrasta, Aldo Giannì, Valeria Sordi, Francesco Petrella, Leda Roncoroni, Francesca Paino, Augusto Pessina Abstract Malignant pleural mesothelioma is an asbestos-related tumor originating in mesothelial cells of the pleura that poorly responds to chemotherapeutic…
Read MoreTraditional Treatment Approaches and Role of Immunotherapy in Lung Malignancy and Mesothelioma
Cancer Treatment and Research 2023 [Link] Mirza Tasnia Tamanna, Christopher Egbune Abstract There is no denying that many revolutions took place in the fight against cancer during the last decades. However, cancers have always managed to find new ways to challenge humankinds. Variable genomic epidemiology, socio-economic differences and limitations of widespread screening are the major…
Read MoreNew Markers for Management of Mesothelioma
Seminars in Respiratory Critical Care Medicine 2023 May 30 [Link] Alistair Nash, Tina Firth Née Phan, Jenette Creaney Abstract In this review, we provide an update on the status of cancer biomarkers for the clinical management of pleural mesothelioma, an aggressive cancer associated with asbestos exposure. Mesothelioma can be difficult to diagnose, and response to…
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