Second line therapy in malignant pleural mesothelioma: A systematic review

Lung Cancer 2015 June 23 [Epub ahead of print] [Link] Buikhuisen WA, Hiddinga BI, Baas P, van Meerbeeck JP. Abstract After the implementation of standard first line chemotherapy with platinum and antifolates in pleural mesothelioma, patients are confronted with a need for second line treatment at relapse or progression. We conducted a systematic review of…

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Malignant Mesothelioma Diagnosed by Bronchoscopic Biopsy

Tuberculosis and Respiratory Diseases 2015 July [Link] Park YH, Choi JW, Jung SO, Cho MJ, Kang DH, Chung CU, Park DI, Moon JY, Park HS, Jung SS, Kim JO, Kim SY, Lee JE. Abstract Malignant mesothelioma is a rare malignant neoplasm that arises from mesothelial surfaces of the pleural cavity, peritoneal cavity, tunica vaginalis, or…

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ALK Translocation in Paediatric Malignant Peritoneal Mesothelioma: A Case Report of Novel ALK-Related Tumour Spectrum

Histopathology 2015 July 14 [Epub ahead of print] [Link] Loharamtaweethong K, Puripat N, Aoonjai N, Sutepvarnon A, Bandidwattanawong C. Abstract Aims To report a case of paediatric malignant peritoneal mesothelioma (MPM) with evidence of anaplastic lymphoma kinase (ALK) translocation. Materials and Results We describe a 10-year-old girl who presented with abdominal pain and progressive abdominal…

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Cerebral Metastasis of a Malignant Pleural Mesothelioma: A Case Report and Review of the Literature

Cureus 2015 January 15 [Link] Chari A, Kolias AG, Allinson K, Santarius T. Abstract Background Malignant pleural mesothelioma (MPM) is an aggressive malignant neoplasm that was thought to be a localised disease with limited metastatic capability. However, recent post-mortem studies have identified metastases to the central nervous system (CNS) in about 3% of cases. Case…

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Malignant mesothelioma in the peritoneal cavity – a case report

Rozhledy v chirurgii 2015 Spring [Link] Rupert K, TÅ™eÅ¡ka V. Abstract Malignant mesothelioma is a rare tumour with an incidence of 0.53 cases per million inhabitants. Only about 20% of cases occur in the peritoneum. The authors use the case report of a male patient with malignant mesothelioma occurring in the peritoneal cavity to demonstrate…

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Comprehensive Review of BAP1 Tumor Predisposition Syndrome with Report of Two New Cases

Clinical Genetics 2015 June 22 [Epub ahead of print] [Link] Rai K, Pilarski R, Cebulla CM, Abdel-Rahman MH. Abstract The BRCA1 associated protein-1 (BAP1) tumor predisposition syndrome (BAP1-TPDS) is a recently identified hereditary cancer syndrome. Germline mutations in this tumor suppressor gene predispose families to the development of various malignancies. The molecular functions of the…

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Nuclear Brachyury Expression Is Consistent in Chordoma, Common in Germ Cell Tumors and Small Cell Carcinomas, and Rare in Other Carcinomas and Sarcomas: An Immunohistochemical Study of 5229 Cases

American Journal of Surgical Pathology 2015 April 4 [Epub ahead of print] [Link] Miettinen M, Wang Z, Lasota J, Heery C, Schlom J, Palena C. Abstract Brachyury is a transcription factor of the T-box family typically expressed in notochord and chordoma. Some studies report brachyury as highly specific for chordoma, whereas others have concluded that…

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