Case Study
Enduring health effects of asbestos use in Belgian industries: a record-linked cohort study of cause-specific mortality (2001-2009)
BMJ Open 2015 June 24 [Link] Van den Borre L, Deboosere P. Abstract Objective To investigate cause-specific mortality among asbestos workers and potentially exposed workers in Belgium and evaluate potential excess in mortality due to established and suspected asbestos-related diseases. Design This cohort study is based on an individual record linkage between the 1991 Belgian…
Read MoreTreatment patterns and survival analysis in 9014 patients with malignant pleural mesothelioma from Belgium, the Netherlands and England
Lung Cancer 2015 May 22 [Epub ahead of print] [Link] Damhuis RA, Khakwani A, De Schutter H, Rich AL, Burgers JA, van Meerbeeck JP. Abstract Introduction Pleural mesothelioma has a dismal prognosis and is refractory to local treatment. Combination chemotherapy can increase median survival by several months and was gradually introduced in the period 2003-2006.…
Read MoreTargeting glucosylceramide synthase induction of cell surface globotriaosylceramide (Gb3) in acquired cisplatin-resistance of lung Cancer and malignant pleural mesothelioma cells
Experimental Cell Research 2015 May 21 [Epub ahead of print] [Link] Tyler A, Johansson A, Karlsson T, Kumar Gudey S, Brännström T, Grankvist K, Behnam-Motlagh P. Abstract Background Acquired resistance to cisplatin treatment is a caveat when treating patients with non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma (MPM). Ceramide increases in response to…
Read MoreMalignant mesothelioma as an oxidative stress-induced cancer: An update
Free Radical Biology and Medicine 2015 May 11 [Epub ahead of print] [Link] Chew SH, Toyokuni S. Abstract Malignant mesothelioma (MM) is a relatively rare cancer that occurs almost exclusively following respiratory exposure to asbestos in humans. Its pathogenesis is closely associated with iron overload and oxidative stress in mesothelial cells. Upon fiber exposure, mesothelial…
Read MoreDesmoplastic malignant mesothelioma of the peritoneum
Oxford Medical Case Reports 2014 June 14 [Link] Badak B, Turk O, Ates E, Arik D. Abstract Malignant mesothelioma is an uncommon neoplasm arising in body cavities lined by the mesothelium. Immunohistochemical stains are useful for making a diagnosis, but the correct combination of antibodies as should be selected in a comprehensive assessment. A peritoneal…
Read MoreLocalized malignant pleural mesothelioma with renal metastasis
Oxford Medical Case Reports 2015 January 14 [Link] Zardawi SJ, Li BT, Zauderer MG, Wang JW, Atmore BB, Barnes TA, Pavlakis N, Mathur MN, Clarke S. Abstract Localized malignant pleural mesothelioma (LMM) is a rare subset of malignant pleural mesothelioma. Its epidemiology, biology, natural history and optimal treatment are poorly understood. We report a case…
Read MoreMesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma
BMC Cancer 2015 May 8 [Epub ahead of print] [Link] Kalra N, Zhang J, Thomas A, Xi L, Cheung M, Talarchek J, Burkett S, Tsokos MG, Chen Y, Raffeld M, Miettinen M, Pastan I, Testa JR, Hassan R. Abstract Background The development and evaluation of new therapeutic approaches for malignant mesothelioma has been sparse due,…
Read MoreClaudin 3, 4, and 15 expression in solid tumors of lung adenocarcinoma versus malignant pleural mesothelioma
Annals of Diagnostic Pathology 2015 April 14 [Epub ahead of print] [Link] Chaouche-Mazouni S, Scherpereel A, Zaamoum R, Mihalache A, Amir ZC, Lebaïli N, Delaire B, Gosset P. Abstract Epithelioid malignant pleural mesothelioma (MPM) can easily be confused with lung adenocarcinomas (ACAs). In serous effusion, claudin (cldn) 3 is shown to be useful in the…
Read MoreChemokine (C-C motif) ligand 3 detection in the serum of persons exposed to asbestos: A patient-based study
Cancer Science 2015 May 2 [Epub ahead of print] [Link] Xu J, Alexander DB, Iigo M, Hamano H, Takahashi S, Yokoyama T, Kato M, Usami I, Tokuyama T, Tsutsumi M, Tamura M, Oguri T, Niimi A, Hayashi Y, Yokoyama Y, Tonegawa K, Fukamachi K, Futakuchi M, Sakai Y, Suzui M, Kamijima M, Hisanaga N, Omori…
Read MoreMalignant (Diffuse) Mesothelioma in Patients With Hematologic Malignancies: A Clinicopathologic Study of 45 Cases
Archives of Pathology and Laboratory Medicine 2015 April 6 [Epub ahead of print] [Link] Li X, Brownlee NA, Sporn TA, Mahar A, Roggli VL. Abstract Context Ionizing radiation has a role in the development of malignant mesothelioma, in several epidemiologic studies, including patients with hematologic malignancies. Objective To study the clinicopathologic characteristics of patients with…
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