Modern Rheumatology. 2006;16(3):165-8. [Link]

Ryusuke Yoshimi¹, Mitsuhiro Takeno¹, Shoji Yamanaka², Masaaki Shiina³, Yohei Kirino¹, Yukiko Takeda¹, Akiko Sekiguchi¹, Hiroshi Kobayashi¹, Atsushi Ihata¹, Kyosuke Motoji¹, Shigeru Ohno⁴, Atsuhisa Ueda¹, Takayoshi Soga¹ and Yoshiaki Ishigatsubo¹

(1) Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
(2) Division of Anatomic and Surgical Pathology, Hospital of Yokohama City University, Yokohama, Japan
(3) Department of Biochemistry, Yokohama City University Graduate School of Medicine, Yokohama, Japan
(4) Chronic Intractable Center, Yokohama City University Medical Center, Yokohama, Japan

Abstract

A 55-year-old man, diagnosed with systemic sclerosis (SSc) for 20 years, was admitted to our hospital for exertional dyspnea and pleural effusion. Computed tomography scan and cytological findings of the pleural fluid suggested malignant mesothelioma. In the postmortem examination, the tumor was pathologically diagnosed as pseudomesotheliomatous adenocarcinoma (PMA) of the lung, classified into pleomorphic carcinoma with adenocarcinoma component according to the new World Health Organization guidelines. This is the first case report of SSc with PMA.