Modern Rheumatology. 2006;16(3):165-8. [Link]
Ryusuke Yoshimi1, Mitsuhiro Takeno1, Shoji Yamanaka2, Masaaki Shiina3, Yohei Kirino1, Yukiko Takeda1, Akiko Sekiguchi1, Hiroshi Kobayashi1, Atsushi Ihata1, Kyosuke Motoji1, Shigeru Ohno4, Atsuhisa Ueda1, Takayoshi Soga1 and Yoshiaki Ishigatsubo1
(1) Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
(2) Division of Anatomic and Surgical Pathology, Hospital of Yokohama City University, Yokohama, Japan
(3) Department of Biochemistry, Yokohama City University Graduate School of Medicine, Yokohama, Japan
(4) Chronic Intractable Center, Yokohama City University Medical Center, Yokohama, Japan
A 55-year-old man, diagnosed with systemic sclerosis (SSc) for 20 years, was admitted to our hospital for exertional dyspnea and pleural effusion. Computed tomography scan and cytological findings of the pleural fluid suggested malignant mesothelioma. In the postmortem examination, the tumor was pathologically diagnosed as pseudomesotheliomatous adenocarcinoma (PMA) of the lung, classified into pleomorphic carcinoma with adenocarcinoma component according to the new World Health Organization guidelines. This is the first case report of SSc with PMA.
Keywords: Mesothelioma – Neoplasm – Pleomorphic carcinoma – Pseudomesotheliomatous adenocarcinoma (PMA) – Systemic sclerosis (SSc)