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Curated Journal Articles on Mesothelioma

Category Archives: Biomarkers

Tissue-specific significance of BAP1 gene mutation in prognostic prediction and molecular taxonomy among different types of cancer.

Tumor Biology 2017 June [a href=”https://www.ncbi.nlm.nih.gov/pubmed/28618948″>Link Wang XY, Wang Z, Huang JB, Ren XD, Ye D1,, Zhu WW, Qin LXM Abstract BAP1 is an emerging tumor suppressor whose inactivating mutations have been found to play critical roles in tumor development. This study was conducted to elucidate the potential value of BAP1 mutation in guiding prognostic […]

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Biomarkers for early diagnosis of malignant mesothelioma: Do we need another moonshot?

Oncotarget 2017 May 17 [Epub ahead of print] [Link] Lagniau S, Lamote K, van Meerbeeck JP2, Vermaelen KY Abstract Early diagnosis of malignant pleural mesothelioma (MPM) is a challenge for clinicians. The disease is usually detected in an advanced stage which precludes curative treatment. We assume that only new and non-invasive biomarkers allowing earlier detection […]

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Improved diagnosis and prognostication of patients with pleural malignant mesothelioma using biomarkers in pleural effusions and peripheral blood samples – a short report

Cell Oncology 2017 June 2 [Epub ahead of print] [Link] Beije N, Kraan J, den Bakker MA, Maat APWM, van der Leest C, Cornelissen R, Van NM, Martens JWM, Aerts JGJV, Sleijfer S Abstract PURPOSE: There is a lack of robust and clinically utilizable markers for the diagnosis and prognostication of malignant pleural mesothelioma (MPM). […]

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Whole exome sequencing of an asbestos-induced wild-type murine model of malignant mesothelioma

BMC Cancer 2017 June 2 [Link] Sneddon S, Patch AM, Dick IM, Kazakoff S, Pearson JV, Waddell N, Allcock RJN, Holt RA, Robinson BWS, Creaney J Abstract BACKGROUND: Malignant mesothelioma (MM) is an aggressive cancer of the pleural and peritoneal cavities caused by exposure to asbestos. Asbestos-induced mesotheliomas in wild-type mice have been used extensively […]

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A Subset of Malignant Mesotheliomas in Young Adults are Associated With Recurrent EWSR1/FUS-ATF1 Fusions

The American Journal of Surgical Pathology 2017 May 12 [Epub ahead of print] [Link] Desmeules P, Joubert P, Zhang L, Al-Ahmadie HA, Fletcher CD, Vakiani E, Delair DF, Rekhtman N, Ladanyi M, Travis WD, Antonescu CR Abstract Malignant mesothelioma (MM) is a rare, aggressive tumor often associated with asbestos exposure and characterized by complex genetic […]

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BAP1 mutations in high-grade meningioma: implications for patient care

Neuro-oncology 2017 May [Epub ahead of print] [Link] Shankar GM, Santagata S Abstract We have recently shown that the BAP1 (BRCA1-associated protein-1) tumor suppressor gene is inactivated in a subset of clinically-aggressive meningiomas that display rhabdoid histomorphology. Immunohistochemistry for BAP1 protein provides a rapid and inexpensive method for screening suspected cases. Notably, some patients with […]

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Plasmatic extracellular vesicle microRNAs in malignant pleural mesothelioma and asbestos-exposed subjects suggest a 2-miRNA signature as potential biomarker of disease.

PLoS One May 4 2017 [Link] Cavalleri T, Angelici L, Favero C, Dioni L, Mensi C, Bareggi C, Palleschi A, Rimessi A, Consonni D, Bordini L, Todaro A, Bollati V, Pesatori AC2, Abstract BACKGROUND: Malignant Pleural Mesothelioma (MPM) is an aggressive cancer mainly caused by asbestos exposure and refractory to current therapies. Specific diagnostic markers […]

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miR-130A as a diagnostic marker to differentiate malignant mesothelioma from lung adenocarcinoma in pleural effusion cytology

Cancer 2017 April 27 [Epub ahead of print] [Link] Cappellesso R, Galasso M, Nicolè L, Dabrilli P, Volinia S, Fassina A Abstract BACKGROUND: Malignant pleural mesothelioma is a rare tumor with a dismal prognosis, usually presenting with recurrent effusions. However, the majority of malignant pleural effusions are due to lung adenocarcinoma (AdC). The distinction between […]

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Folic acid phenotype (FAP) is a superior biomarker predicting response to pemetrexed-based chemotherapy in malignant pleural mesothelioma

Oncotarget 2017 March [Epub ahead of print] [Link] Mairinger FD, Vollbrecht C, Flom E, Christoph DC, Schmid KW, Kollmeier J, Popper HH, Mairinger T, Walter RFH Abstract BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare tumor linked to a dismal prognosis. Even the most effective chemotherapeutical regime of pemetrexed combined with cisplatin leads to a […]

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Epidemiology of Environmental Exposure and Malignant Mesothelioma.

Journal of Thoracic Oncology 2017 April [Epub ahead of print] [Link] Bian L, van Gerwen M, Bonassi S, Taioli E; IASLC Mesothelioma Taskforce Abstract While the association between exposure to asbestos and malignant mesothelioma (MM), particularly malignant pleural mesothelioma (MPM) has been well established, the health impact of environmental exposure (EE) to asbestos is less […]

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