MesotheliomaCenter's

Mesothelioma-Line

Curated Journal Articles on Mesothelioma

Category Archives: Biomarkers

MicroRNA Expression in Malignant Pleural Mesothelioma and Asbestosis: A Pilot Study

Disease Markers 2017 [Epub July 3] [Link] Mozzoni P, Ampollini L, Goldoni M, Alinovi R, Tiseo M, Gnetti L, Carbognani P, Rusca M, Mutti A, Percesepe A, Corradi Abstract BACKGROUND: The identification of diagnostic/prognostic biomarkers for asbestos-related diseases is relevant for early diagnosis and patient survival and may contribute to understanding the molecular mechanisms underlying […]

Comments Off on MicroRNA Expression in Malignant Pleural Mesothelioma and Asbestosis: A Pilot Study

Indolent peritoneal mesothelioma: PI3K-mTOR inhibitors as a novel therapeutic strategy

ESMO 2017 April [Link] Dolly SO, Migali C, Tunariu N, Della-Pepa C, Khakoo S, Hazell S, de Bono JS, Kaye SB, Banerjee S Abstract Peritoneal mesothelioma (MPeM) is a scarce abdominal-pelvic malignancy that presents with non-specific features and exhibits a wide clinical spectrum from indolent to aggressive disease. Due to it being a rare entity, […]

Comments Off on Indolent peritoneal mesothelioma: PI3K-mTOR inhibitors as a novel therapeutic strategy

Tumor suppressor candidate 2 (TUSC2, FUS-1) and human cancers

Discovery Medicine 2017 May [Link Rimkus T, Sirkisoon S, Harrison A, Lo HW Abstract Tumor suppressor candidate 2 (TUSC2, also known as FUS1) was identified in 2000 as a candidate tumor suppressor gene located in a region on chromosome 3p21.3 that is homozygously deleted in some lung and breast cancers. The deletion is rare in […]

Comments Off on Tumor suppressor candidate 2 (TUSC2, FUS-1) and human cancers

Immunohistochemical evaluation of two antibodies against PD-L1 and http://www.mesothelioma-line.com/wp-login.php?action=logout&_wpnonce=d22f9156abprognostic significance of PD-L1 expression in epithelioid peritoneal malignant mesothelioma: A RENAPE study

European Journal of Surgical Oncology 2017 May [Epub ahead of print] [Link] Valmary-Degano S, Colpart P, Villeneuve L, Monnien F, M’Hamdi L, Lang Averous G, Capovilla M, Bibeau F, Laverriere MH, Verriele-Beurrier V, Ben Rejeb H, Dartigues P, Hommell-Fontaine J, Gilly FN, Isaac S, Mery E; French RENAPE Network Abstract BACKGROUND: Epithelioid peritoneal malignant mesothelioma […]

Comments Off on Immunohistochemical evaluation of two antibodies against PD-L1 and http://www.mesothelioma-line.com/wp-login.php?action=logout&_wpnonce=d22f9156abprognostic significance of PD-L1 expression in epithelioid peritoneal malignant mesothelioma: A RENAPE study

Posttranscriptional Regulation Controls Calretinin Expression in Malignant Pleural Mesothelioma

Frontiers in Genetics 2017 May [Link] Kresoja-Rakic J, Sulemani M, Kirschner MB, Ronner M, Reid G, Kao S, Schwaller B, Weder W, Stahel RA, Felley-Bosco E Abstract Calretinin (CALB2) is a diagnostic and prognostic marker in malignant pleural mesothelioma (MPM). We previously reported that calretinin expression is regulated at the mRNA level. The presence of […]

Comments Off on Posttranscriptional Regulation Controls Calretinin Expression in Malignant Pleural Mesothelioma

Tissue-specific significance of BAP1 gene mutation in prognostic prediction and molecular taxonomy among different types of cancer.

Tumor Biology 2017 June [a href=”https://www.ncbi.nlm.nih.gov/pubmed/28618948″>Link Wang XY, Wang Z, Huang JB, Ren XD, Ye D1,, Zhu WW, Qin LXM Abstract BAP1 is an emerging tumor suppressor whose inactivating mutations have been found to play critical roles in tumor development. This study was conducted to elucidate the potential value of BAP1 mutation in guiding prognostic […]

Comments Off on Tissue-specific significance of BAP1 gene mutation in prognostic prediction and molecular taxonomy among different types of cancer.

Biomarkers for early diagnosis of malignant mesothelioma: Do we need another moonshot?

Oncotarget 2017 May 17 [Epub ahead of print] [Link] Lagniau S, Lamote K, van Meerbeeck JP2, Vermaelen KY Abstract Early diagnosis of malignant pleural mesothelioma (MPM) is a challenge for clinicians. The disease is usually detected in an advanced stage which precludes curative treatment. We assume that only new and non-invasive biomarkers allowing earlier detection […]

Comments Off on Biomarkers for early diagnosis of malignant mesothelioma: Do we need another moonshot?

Improved diagnosis and prognostication of patients with pleural malignant mesothelioma using biomarkers in pleural effusions and peripheral blood samples – a short report

Cell Oncology 2017 June 2 [Epub ahead of print] [Link] Beije N, Kraan J, den Bakker MA, Maat APWM, van der Leest C, Cornelissen R, Van NM, Martens JWM, Aerts JGJV, Sleijfer S Abstract PURPOSE: There is a lack of robust and clinically utilizable markers for the diagnosis and prognostication of malignant pleural mesothelioma (MPM). […]

Comments Off on Improved diagnosis and prognostication of patients with pleural malignant mesothelioma using biomarkers in pleural effusions and peripheral blood samples – a short report

Whole exome sequencing of an asbestos-induced wild-type murine model of malignant mesothelioma

BMC Cancer 2017 June 2 [Link] Sneddon S, Patch AM, Dick IM, Kazakoff S, Pearson JV, Waddell N, Allcock RJN, Holt RA, Robinson BWS, Creaney J Abstract BACKGROUND: Malignant mesothelioma (MM) is an aggressive cancer of the pleural and peritoneal cavities caused by exposure to asbestos. Asbestos-induced mesotheliomas in wild-type mice have been used extensively […]

Comments Off on Whole exome sequencing of an asbestos-induced wild-type murine model of malignant mesothelioma

A Subset of Malignant Mesotheliomas in Young Adults are Associated With Recurrent EWSR1/FUS-ATF1 Fusions

The American Journal of Surgical Pathology 2017 May 12 [Epub ahead of print] [Link] Desmeules P, Joubert P, Zhang L, Al-Ahmadie HA, Fletcher CD, Vakiani E, Delair DF, Rekhtman N, Ladanyi M, Travis WD, Antonescu CR Abstract Malignant mesothelioma (MM) is a rare, aggressive tumor often associated with asbestos exposure and characterized by complex genetic […]

Comments Off on A Subset of Malignant Mesotheliomas in Young Adults are Associated With Recurrent EWSR1/FUS-ATF1 Fusions