Extended Pleurectomy-Decortication-Based Treatment for Advanced Stage Epithelial Mesothelioma Yielding a Median Survival of Nearly Three Years

The Annals of Thoracic Surgery 2016 November 5 [Epub ahead of print] Link] Friedberg JS, Simone CB 2nd, Culligan MJ, Barsky AR, Doucette A, McNulty S, Hahn SM, Alley E, Sterman DH, Glatstein E, Cengel KA Abstract BACKGROUND: The purpose of this study was to assess survival for patients with malignant pleural mesothelioma (MPM), epithelial…

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Illumination profile characterization of a light device for the dosimetry of intra-pleural photodynamic therapy for mesothelioma

Photodiagnosis and photodynamic therapy 2016 September 1 [Epub ahead of print] [Link] Munck C, Mordon S, Betrouni N Abstract BACKGROUND: Complete and homogeneous illumination of the pleural cavity is essential to the success of photodynamic therapy (PDT) for mesothelioma, but remains a challenge. Knowing the repartition and propagation of light around the light applicator could…

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An IR Navigation System for Pleural PDT

Frontiers in Physics 2015 March [Link] Zhu TC, Liang X, Kim MM, Finlay JC, Dimofte A, Rodriguez C, Simone CB, Friedberg JS, Cengel KA. Abstract Pleural photodynamic therapy (PDT) has been used as an adjuvant treatment with lung-sparing surgical treatment for malignant pleural mesothelioma (MPM). In the current pleural PDT protocol, a moving fiber-based point…

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Fluence plays a critical role on the subsequent distribution of chemotherapy and tumor growth delay in murine mesothelioma xenografts pre-treated by photodynamic therapy

Lasers in Surgery and Medicine 2015 January 12 [Epub ahead of print] [Link] Wang Y, Wang X, Le Bitoux MA, Wagnieres G, Vandenbergh H, Gonzalez M, Ris HB, Perentes JY, Krueger T. Abstract Background The pre-conditioning of tumor vessels by low-dose photodynamic therapy (L-PDT) was shown to enhance the distribution of chemotherapy in different tumor…

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A case of advanced malignant pleural mesothelioma treatment with chemotherapy and photodynamic therapy

Tuberculosis and Respiratory Diseases 2015 January [Link] Ryu JW, Kim YS. Abstract Malignant pleural mesothelioma (MPM) is an aggressive, treatment-resistant, and generally fatal disease. A 68-year-old male who was diagnosed with MPM at another hospital came to our hospital with dyspnea. We advised him to take combination chemotherapy but he refused to take the treatment.…

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Photodynamic therapy for lung cancer and malignant pleural mesothelioma

Seminars in Oncology 2014 December [Link] Simone CB 2nd, Cengel KA. Abstract Photodynamic therapy (PDT) is a form of non-ionizing radiation therapy that uses a drug, called a photosensitizer, combined with light to produce singlet oxygen ((1)O2) that can exert anti-cancer activity through apoptotic, necrotic, or autophagic tumor cell death. PDT is increasingly being used…

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Multimodal therapy of malignant pleural mesothelioma: is the replacement of radical surgery imminent?

Interactive CardioVasic and Thoracic Surgery. 2012 Nov 21. [Epub ahead of print] [Link] Lindenmann J, Matzi V, Neuboeck N, Anegg U, Maier A, Smolle J, Smolle-Juettner FM. Division of Thoracic and Hyperbaric Surgery, Department of Surgery, Medical University of Graz, Austria. Abstract Aims: The accurate diagnosis of malignant pleural mesothelioma (MPM) is essential for therapeutic…

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Malignant mesothelioma 2008

Current Opinion in Pulmonary Medicine. 14(4):303-309, July 2008. [Link] Zervos MD, Bizekis C, Pass HI. Department of Cardiothoracic Surgery, Division of Thoracic Surgery, New York University School of Medicine, New York, USA. zervom01@med.nyu.edu Abstract Purpose of review: Mesothelioma is an aggressive malignancy of the pleura with poor survival. There will be approximately 3000 cases of…

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Polyhematoporphyrin-mediated photodynamic therapy and decortication in palliation of malignant pleural mesothelioma: a clinical pilot study

Interactive Cardiovascular and Thoracic Surgery. 3:52-56(2004) [Link] Matzi V, Maier A, Woltsche M, Smolle-Jüttner FM. Department of Surgery, Division of Thoracic and Hyperbaric Surgery, University Medical School, Auenbruggerplatz 29, A-8036 Graz, Austria. Abstract The aim of this study was to evaluate the additional effect of intraoperative photodynamic therapy (PDT) under hyperbaric oxygenation (HBO) when compared…

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