Chemotherapy
Comparison of video-assisted pleurectomy/decortication surgery plus hyperthermic intrathoracic chemotherapy with VATS talc pleurodesis for the treatment of malignant pleural mesothelioma: A pilot study
Heliyon 2023 May 25 [Link] Marcello Migliore, Maria Fiore, Tommaso Filippini, Rosario Tumino, Mara Sabbioni, Corrado Spatola, Riccardo Polosa, Paolo Vigneri, Marco Nardini, Sergio Castorina, Francesco Basile, Margherita Ferrante Abstract Hyperthermic intrathoracic chemotherapy (HITHOC) adjunct to surgery for Malignant Pleural Mesothelioma (MPM) has no definite role. The primary objective of this pilot-trial was to evaluate…
Read MoreLA-ICP-MS analysis reveals differences in chemotherapeutic drug distribution in surgically resected pleural mesothelioma
British Journal of Clinical Pharmacology 2023 June 5 [Link] Anna Tisza, Thomas Klikovits, Michal Benej, Szilvia Torok, Beata Szeitz, Zsuzsanna Valko, Mir Alireza Hoda, Balazs Hegedus, Maximilian Bonta, Winfried Nischkauer, Konrad Hoetzenecker, Andreas Limbeck, Karin Schelch, Viktoria Laszlo, Zsolt Megyesfalvi, Balazs Dome Abstract Aims: Pleural mesothelioma (PM) is a highly aggressive thoracic tumor with poor…
Read MoreTargeting AXL in mesothelioma: From functional characterization to clinical implication
Critical Reviews in Oncology and Hematology 2023 June 1 [Link] Kinjal Bhadresha, Sheefa Mirza, Clement Penny, Muhammed Jameel Mughal Abstract Malignant mesothelioma (MM) is a highly aggressive and lethal cancer with a poor survival rate. Current treatment approaches primarily rely on chemotherapy and radiation, but their effectiveness is limited. Consequently, there is an urgent need…
Read MoreCytoreductive surgery (CRS) and heated intraperitoneal chemotherapy (HIPEC) for peritoneal mesothelioma: Canadian practices and outcomes
Journal of Surgical Oncology 2023 May 30 [Link] Melina Deban, Kadhim Taqi, Gregory C Knapp, Mikael Soucisse, Matt Curry, Lucas Sidéris, Pierre Dubé, Maher Al Khaldi, Nicole Jedrzejko, Geoff Porter, Carman Giacomantonio, Trevor Hamilton, Andrea MacNeill, Lloyd Mack, Antoine Bouchard-Fortier Abstract Introduction: Peritoneal mesothelioma (PM) is a rare malignancy originating from the peritoneal lining. Cytoreductive…
Read MoreNew Markers for Management of Mesothelioma
Seminars in Respiratory Critical Care Medicine 2023 May 30 [Link] Alistair Nash, Tina Firth Née Phan, Jenette Creaney Abstract In this review, we provide an update on the status of cancer biomarkers for the clinical management of pleural mesothelioma, an aggressive cancer associated with asbestos exposure. Mesothelioma can be difficult to diagnose, and response to…
Read MoreMatrigel-based organoid culture of malignant mesothelioma reproduces cisplatin sensitivity through CTR1
BMC Cancer 2023 May 31 [Link] Fumiya Ito, Katsuhiro Kato, Izumi Yanatori, Yuki Maeda, Toyoaki Murohara, Shinya Toyokuni Abstract Organoids are a three-dimensional (3D) culture system that simulate actual organs. Therefore, tumor organoids are expected to predict precise response to chemotherapy in patients. However, to date, few studies have studied the drug responses in organoids…
Read MoreCombination therapy with anti-programmed cell death 1 antibody plus angiokinase inhibitor exerts synergistic antitumor effect against malignant mesothelioma via tumor microenvironment modulation
Lung Cancer 2023 June [Link] Akio Tada, Toshiyuki Minami, Hidemi Kitai, Yoko Higashiguchi, Mayuko Tokuda, Tomoki Higashiyama, Yoshiki Negi, Daisuke Horio, Yasuhiro Nakajima, Taiichiro Otsuki, Koji Mikami, Ryo Takahashi, Akifumi Nakamura, Kazuhiro Kitajima, Masaki Ohmuraya, Kozo Kuribayashi, Takashi Kijima Abstract Malignant pleural mesothelioma (MPM) is an asbestos-related fatal malignant neoplasm. Although there has been no…
Read MoreGeldanamycin treatment does not result in anti-cancer activity in a preclinical model of orthotopic mesothelioma
PloS One 2023 May 5 [Link] M Lizeth Orozco Morales, Catherine A Rinaldi, Emma de Jong, Sally M Lansley, Y C Gary Lee, Rachael M Zemek, Anthony Bosco, Richard A Lake, W Joost Lesterhuis Abstract Mesothelioma is characterised by its aggressive invasive behaviour, affecting the surrounding tissues of the pleura or peritoneum. We compared an…
Read MoreConcurrent induction of apoptosis and necroptosis in apigenin‑treated malignant mesothelioma cells: Reversal of Warburg effect through Akt inhibition and p53 upregulation
Oncology Reports 2023 June [Link] Yoon-Jin Lee, Kwan-Sik Park, Su-Hak Heo, Moon-Kyun Cho, Sang-Han Lee Abstract A high dependence on aerobic glycolysis, known as the Warburg effect, is one of the metabolic features exhibited by tumor cells. Therefore, targeting glycolysis is becoming a very promising strategy for the development of anticancer drugs. In the present…
Read MoreIndividualized prediction of survival benefit from postoperative radiotherapy for patients with malignant pleural mesothelioma
Cancer Medicine 2023 April 19 [Link] Yang Wo, Yizhou Peng, Zhigang Wu, Pengcheng Liu, Yan Shang, Xuxia Shen, Yihua Sun Abstract Objectives: The role of postoperative radiotherapy (PORT) in malignant pleural mesothelioma (MPM) remains controversial and the eighth edition TNM staging scheme for MPM has not been fully verified. We aimed to develop an individualized…
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