Cellular Physiology and Biochemistry 2018 January 15 [Epub ahead of print] [Link]

Zhang S, Zhang Q, Sun Q, Tang J, Chen J, Ji N, Zheng Y, Fang F, Lei W, Li P, Zhang N


Malignant mesothelioma of the tunica vaginalis testis is a rare and lethal disease. The genomic characteristics and genetic changes of tumor cells during the progression of this disease are unknown.

we performed whole-genome sequencing of four successive tumor samples derived from surgery and a blood sample in a single patient.

All tumors were found to have significant C-to-T and T-to-C mutations, and amplification of copy number in chromosomes 1 and 12 were notified in all tumor samples. Subclone analysis revealed a parallel evolution of the tumor in this patient. We also identified some mutations in mesothelioma-associated genes such as KIF25, AHNAK, and PRDM2.

The results showed a comprehensive genomic change in malignant mesothelioma of the tunica vaginalis testis and provide a better understanding of the clonal evolution during tumor recurrence and metastasis.